Alexaki and Wigdahl discuss HIV-1 replication within bone marrow, and suggest that the resultant infection of bone marrow hematopoietic progenitor cells may be involved in the early steps leading to the development of HIV-1-associated dementia (HAD) as an end result of this cellular trafficking process.
Ferrari et al. investigate the occurrence of GOF mutations in a large collection of azole-resistant isolates, finding novel evidence that mutations causing antifungal resistance can also provide a selective advantage under host conditions.
Quentin et al. evaluate how a model plant, which was mutated for a key enzyme in lignin biosynthesis, interacts with pathogens from different kingdoms. The findings indicate that interfering with lignin composition may drastically alter the outcome of plant–pathogen interactions.
Walters et al. conduct microarray experiments to characterize the host transcriptional response to HCV infection of cultured hepatocytes, finding that HCV may mediate direct cytopathic effects through perturbation of the cell cycle which potentially contributes to liver disease progression.
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