Institute(s)

Project

Investigators

NINDS
NIDCD

"Induction of volitional swallowing in chronic dysphagia post stroke: A novel mechanism-based intervention"

PI: C. Ludlow, PhD, NINDS
PI: L. Cohen, MD, NINDS
PI: B. Horwitz, PhD, NIDCD

 NHLBI
NINDS

"Induction of Mucosal Tolerance to Recombinant Human E-Selectin for the treatment of Myocardial Ischemia-Reperfusion Injury and Symptomatic Coronary Atherosclerosis. A Collaborative NHLBI/NINDS Investigation"

PI: R. deSilva, MB, BS, PhD, NHLBI
PI: J. Hallenbeck, MD, NINDS
PI: T. Finkel, MD, PhD, NHLBI
AIs from NHLBI, NINDS

Institute(s)

Project

Investigators

NCI
NHGRI

"Natural history, biology and treatment of dermal neurofibromas in neurofibromatosis type 1 (NF1)"

PI: B. Widemann, MD, NCI
PI: D. Stewart, MD, NHGRI
AIs from NCI, NHGRI, Medical Numerics, Inc., Univ of AL

NHGRI
NHLBI

"Testing Treatment of Hutchinson-Gilford Progeria Syndrome with Farnesyl Transferase Inhibitors"

PI: L. Gordon, MD, PhD, NHGRI
PI: D. Orlic, PhD, NHLBI
AIs: Drs. W. Introne, W. Gahl, F. Collins, E. Nabel

NIEHS
NINDS

"Analysis of global gene expression patterns and mitochondrial DNA damage in lymphocytes of Friedreich’s Ataxia patients undergoing idebenone treatment in Phase II double-blind placebo controlled study"

PI: B. Van Houten, PhD, NIEHS
PI: K. Fischbeck, MD, NINDS
AIs: A. Haugen, NIEHS, N. DiProspero, NINDS

NCI
CC, DTM

"Adoptive Cell Therapy for Ewing’s Sarcoma Using Artificial Antigen Presenting Cells"

PI: C. Mackall, M.D.
AIs from CC, NCI, Univ of PA

NICHD
NHGRI

 "Ganaxolone Therapy for Niemann-Pick Type C"

PI: F. Porter, MD, PhD, NICHD
PI: W. Pavan, PhD, NHGRI

NIEHS
NICHD

"UVA Sensitivity in Smith-Lemli-Opitz Syndrome: Possible Involvement of Cholesta -5,7,9(11)-trien-3-ol

PI: C. Chignell, PhD, NIEHS
PI: F. Porter, MD, PhD, NICHD

CC
NCI
NIAID

"Pre-clinical and clinical investigations into the mechanisms and efficacy of extracorporeal photopheresis (ECP) in the abrogation of graft-vs-host disease (GVHD) and facilitation of graft-vs-tumor (GVT) immunity in pediatric patients"

PI: A. Wayne, MD, NCI
PI: T. J. Fry, MD, NCI
AIs: Drs. Bolan, Leitman, Malech, Pavletic

NCI, NICHD

"Site-Selective cAMP Analogs for Treatment of Carney Complex"

PI: Y. Cho-Chung, MD, PhD, NCI
PI: C. Stratakis, MD, NICHD

NIAMS
NHGRI

"Pathogenesis of and risk factors for autoimmunity in the Wiskott-Aldrich Syndrome"

PI: F. Candotti, MD, NHGRI
PI: R. Siegel, MD, PhD, NIAMS
AI: N. Nikolov, MD, NIAMS

NIAID
NCI

"Development of a Specific Drug treatment for WHIM Syndrome"

PI: D. McDermott, MD, NIAID
PI: P. Murphy, MD, NIAID
PI: H. Malech, MD, NIAID
S. Hwang, MD, PhD, NCI
AI: T. Kawai, MD, NIAID

Institute(s)

Project

Investigators

NCI
NIAID

"Role of HIV-1 RNase in Developing Resistance to Nucleoside Analogs"

PI: V. Pathak, PhD, NCI
PI: F. Maldarelli, MD, PhD, NCI
AI: C. Morse, MD, NIAID

NHLBI
CC

"Endothelial Dysfunction in HIV-associated Pulmonary Hypertension"

PI: R. Machado, MD, NHLBI
PI: N. Raghavachari, Ph.D., CC, CCMD
PI: M. Gladwin, MD, NHLBI
AIs: Drs. Barnett, Masur, Lederman, McCoy, Solomon

NCI
NIAID

"Clinical Development of E. coli Nissle 1917 as Host for a Live Anti-HIV Microbicide"

PI: D. Hamer, PhD, NCI
PI: I. Sereti, MD, NIAID
AIs: Drs. Asdhya, Henry, Mannon

NIAID
CC

"Persistent HIV Reservoirs in Infected Patients Receiving Effective Antiviral Therapy for Prolonged Periods of Time: Delineation of the Mechanism and Source of Viral Replication and Execution of a New Therapeutic Strategy"

PI: T. Chun, PhD, NIAID
PI: L. Healey, MD, CCMD
AIs: Drs. Moir, Kovacs, Kottilil

CC
NIAID
NINDS

"Identification of Biomarkers of Mitochondrial-related Drug Toxicities in HIV-infected Patients Receiving Highly Active Anti-retroviral Therapy"

PI: J. Kovacs, MD, CCMD
PI: J. Mican, MD, NIAID
AIs: from CCMD, DLM, NINDS