Stage I Laryngeal Cancer
Supraglottis
Glottis
Subglottis
Current Clinical Trials
Supraglottis
Standard treatment options:
- External-beam radiation therapy alone.
- Supraglottic laryngectomy. Total laryngectomy may be reserved for patients
unable to tolerate potential respiratory complications of surgery or the
supraglottic laryngectomy. Radiation, however, should be preferred because of
the good results, preservation of the voice, and the possibility of surgical salvage in
patients whose disease recurs locally.[1]
Glottis
Standard treatment options:
- Radiation therapy.[2-5]
- Cordectomy for very carefully selected patients with limited and superficial
T1 lesions.[6,7]
- Partial or hemilaryngectomy or total laryngectomy, depending on anatomic
considerations.
- Laser excision.[6]
Subglottis
Standard treatment options:
- Lesions can be treated successfully by radiation therapy alone with
preservation of normal voice. Surgery is reserved for failure of radiation
therapy or for patients who cannot be easily assessed for radiation therapy.
Current Clinical Trials
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage I laryngeal cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
References
-
Ogura JH, Sessions DG, Spector GJ: Conservation surgery for epidermoid carcinoma of the supraglottic larynx. Laryngoscope 85 (11 pt 1): 1808-15, 1975.
[PUBMED Abstract]
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Mittal B, Rao DV, Marks JE, et al.: Role of radiation in the management of early vocal cord carcinoma. Int J Radiat Oncol Biol Phys 9 (7): 997-1002, 1983.
[PUBMED Abstract]
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Wang CC: Factors influencing the success of radiation therapy for T2 and T3 glottic carcinomas. Importance of cord mobility and sex. Am J Clin Oncol 9 (6): 517-20, 1986.
[PUBMED Abstract]
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Mendenhall WM, Amdur RJ, Morris CG, et al.: T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol 19 (20): 4029-36, 2001.
[PUBMED Abstract]
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Foote RL, Olsen KD, Kunselman SJ, et al.: Early-stage squamous cell carcinoma of the glottic larynx managed with radiation therapy. Mayo Clin Proc 67 (7): 629-36, 1992.
[PUBMED Abstract]
-
Steiner W: Results of curative laser microsurgery of laryngeal carcinomas. Am J Otolaryngol 14 (2): 116-21, 1993 Mar-Apr.
[PUBMED Abstract]
-
Olsen KD, Thomas JV, DeSanto LW, et al.: Indications and results of cordectomy for early glottic carcinoma. Otolaryngol Head Neck Surg 108 (3): 277-82, 1993.
[PUBMED Abstract]
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