Disclaimer: These guidelines were developed under contract using generally accepted secondary sources. The protocol used by the contractor for surveying these data sources was developed by the National Institute for Occupational Safety and Health (NIOSH), the Occupational Safety and Health Administration (OSHA), and the Department of Energy (DOE). The information contained in these guidelines is intended for reference purposes only. None of the agencies have conducted a comprehensive check of the information and data contained in these sources. It provides a summary of information about chemicals that workers may be exposed to in their workplaces. The secondary sources used for supplements 111 and 1V were published before 1992 and 1993, respectively, and for the remainder of the guidelines the secondary sources used were published before September 1996. This information may be superseded by new developments in the field of industrial hygiene. Therefore readers are advised to determine whether new information is available.

OCCUPATIONAL SAFETY AND HEALTH GUIDELINE FOR CHLORINE

INTRODUCTION

This guideline summarizes pertinent information about chlorine for workers and employers as well as for physicians, industrial hygienists, and other occupational safety and health professionals who may need such information to conduct effective occupational safety and health programs. Recommendations may be superseded by new developments in these fields; readers are therefore advised to regard these recommendations as general guidelines and to determine whether new information is available.

SUBSTANCE IDENTIFICATION

* Formula

Cl(2)

* Structure

Not applicable.

* Synonyms

Bertholite, molecular chlorine

* Identifiers

1. CAS No.: 7782-50-5

2. RTECS No.: FO2100000

3. DOT UN: 1017 20

4. DOT label: Poison gas

* Appearance and odor

Chlorine is a greenish-yellow gas with a characteristic pungent odor. It condenses to an amber liquid at approximately -34 degrees C (-29.2 degrees F) or at high pressures. Odor thresholds ranging from 0.08 to part per million (ppm) parts of air have been reported. Prolonged exposures may result in olfactory fatigue.

CHEMICAL AND PHYSICAL PROPERTIES

* Physical data

1. Molecular weight: 70.9

2. Boiling point (at 760 mm Hg): -34.6 degrees C (-30.28 degrees F)

3. Specific gravity (liquid): 1.41 at 20 degrees C (68 degrees F) and a pressure of 6.86 atm

4. Vapor density: 2.5

5. Melting point: -101 degrees C (-149.8 degrees F)

6. Vapor pressure at 20 degrees C (68 degrees F): 4,800 mm Hg

7. Solubility: Slightly soluble in water; soluble in alkalies, alcohols, and chlorides.

8. Evaporation rate: Data not available.

* Reactivity

1. Conditions contributing to instability: Cylinders of chlorine may burst when exposed to elevated temperatures. Chlorine in solution forms a corrosive material.

2. Incompatibilities: Flammable gases and vapors form explosive mixtures with chlorine. Contact between chlorine and many combustible substances (such as gasoline and petroleum products, hydrocarbons, turpentine, alcohols, acetylene, hydrogen, ammonia, and sulfur), reducing agents, and finely divided metals may cause fires and explosions. Contact between chlorine and arsenic, bismuth, boron, calcium, activated carbon, carbon disulfide, glycerol, hydrazine, iodine, methane, oxomonosilane, potassium, propylene, and silicon should be avoided. Chlorine reacts with hydrogen sulfide and water to form hydrochloric acid, and it reacts with carbon monoxide and sulfur dioxide to form phosgene and sulfuryl chloride. Chlorine is also incompatible with moisture, steam, and water.

3. Hazardous decomposition products: None reported.

4. Special precautions: Chlorine will attack some forms of plastics, rubber, and coatings.

* Flammability

Chlorine is a non-combustible gas.

The National Fire Protection Association has assigned a flammability rating of 0 (no fire hazard) to chlorine; however, most combustible materials will burn in chlorine.

1. Flash point: Not applicable.

2. Autoignition temperature: Not applicable.

3. Flammable limits in air: Not applicable.

4. Extinguishant: For small fires use water only; do not use dry chemical or carbon dioxide. Contain and let large fires involving chlorine burn. If fire must be fought, use water spray or fog.

Fires involving chlorine should be fought upwind from the maximum distance possible. Keep unnecessary people away; isolate the hazard area and deny entry. For a massive fire in a cargo area, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from the area and let the fire burn. Emergency personnel should stay out of low areas and ventilate closed spaces before entering. Containers of chlorine may explode in the heat of the fire and should be moved from the fire area if it is possible to do so safely. If this is not possible, cool fire exposed containers from the sides with water until well after the fire is out. Stay away from the ends of containers. Firefighters should wear a full set of protective clothing and self- contained breathing apparatus when fighting fires involving chlorine.

EXPOSURE LIMITS

* OSHA PEL

The current Occupational Safety and Health Administration (OSHA) permissible exposure limit (PEL) for chlorine is 1 ppm (3 milligrams per cubic meter (mg/m(3))) as a ceiling limit. A worker's exposure to chlorine shall at no time exceed this ceiling level [29 CFR 1910.1000, Table Z-1].

* NIOSH REL

The National Institute for Occupational Safety and Health (NIOSH) has established a recommended exposure limit (REL) for chlorine of 0.5 ppm mg/m(3)) as a TWA for up to a 10-hour workday and a 40-hour workweek and a short-term exposure limit (STEL) of 1 ppm (3 mg/m(3))[NIOSH 1992].

* ACGIH TLV

The American Conference of Governmental Industrial Hygienists (ACGIH) has assigned chlorine a threshold limit value (TLV) of 0.5 ppm (1.5 mg/m(3)) as a TWA for a normal 8-hour workday and a 40-hour workweek and a short-term exposure limit (STEL) of 1.0 ppm (2.9 mg/m(3)) for periods not to exceed 15 minutes. Exposures at the STEL concentration should not be repeated more than four times a day and should be separated by intervals of at least 60 minutes [ACGIH 1994, p. 15].

* Rationale for Limits

The NIOSH limits are based on the risk of severe eye, mucous membrane and skin irritation [NIOSH 1992].

The ACGIH limits are based on the risk of eye and mucous membrane irritation [ACGIH 1991, p. 254].

HEALTH HAZARD INFORMATION

* Routes of Exposure

Exposure to chlorine can occur through inhalation, ingestion, and eye or skin contact [Genium 1992].

* Summary of toxicology

1. Effects on Animals: Chlorine is a severe irritant of the eyes, mucous membranes, skin, and lungs in experimental animals. The 1 hour LC(50) is 239 ppm in rats and 137 ppm in mice ()[Sax and Lewis 1989]. Animals surviving sublethal inhalation exposures for 15 to 193 days showed marked emphysema, which was associated with bronchiolitis and pneumonia [Clayton and Clayton 1982]. Chlorine injected into the anterior chamber of rabbits' eyes resulted in severe damage with inflammation, opacification of the cornea, atrophy of the iris, and injury to the lens [Grant 1986].

2. Effects on Humans: Severe acute effects of chlorine exposure in humans have been well documented since World War I when chlorine gas was used as a chemical warfare agent. Other severe exposures have resulted from the accidental rupture of chlorine tanks. These exposures have caused death, lung congestion, and pulmonary edema, pneumonia, pleurisy, and bronchitis [Hathaway et al. 1991]. The lowest lethal concentration reported is 430 ppm for 30 minutes[Clayton and Clayton 1982]. Exposure to 15 ppm causes throat irritation, exposures to 50 ppm are dangerous, and exposures to 1000 ppm can be fatal, even if exposure is brief [Sax and Lewis 1989; Clayton and Clayton 1982]. Earlier literature reported that exposure to a concentration of about 5 ppm caused respiratory complaints, corrosion of the teeth, inflammation of the mucous membranes of the nose and susceptibility to tuberculosis among chronically-exposed workers. However, many of these effects are not confirmed in recent studies and are of very dubious significance [ACGIH 1991]. A study of workers exposed to chlorine for an average of 10.9 years was published in 1970. All but six workers had exposures below 1 ppm; 21 had TWAs above 0.52 ppm. No evidence of permanent lung damage was found, but 9.4 percent had abnormal EKGs compared to 8.2 percent in the control group. The incidence of fatigue was greater among those exposed above 0.5 ppm [ACGIH 1991]. In 1981, a study was published involving 29 subjects exposed to chlorine concentrations up to 2.0 ppm for 4- and 8-hour periods. Exposures of 1.0 ppm for 8 hours produced statistically significant changes in pulmonary function that were not observed at a 0.5 ppm exposure concentration. Six of 14 subjects exposed to 1.0 ppm for 8 hours showed increased mucous secretions from the nose and in the hypopharynx. Responses for sensations of itching or burning of the nose and eyes, and general discomfort were not severe, but were perceptible, especially at the 1.0 ppm exposure level [ACGIH 1991]. A 1983 study of pulmonary function at low concentrations of chlorine exposure also found transient decreases in pulmonary function at the 1.0 ppm exposure level, but not at the 0.5 ppm level [ACGIH 1991]. Acne (chloracne) is not unusual among persons exposed to low concentrations of chlorine for long periods of time. Tooth enamel damage may also occur [Parmeggiani 1983]. There has been one confirmed case of myasthenia gravis associated with chlorine exposure [NLM 1995].

* Signs and symptoms of exposure

1. Acute exposure: Acute exposure to low levels of chlorine results in eye, nose, and throat irritation, sneezing, excessive salivation, general excitement, and restlessness. Higher concentrations causes difficulty in breathing, violent coughing, nausea, vomiting, cyanosis, dizziness, headache, choking, laryngeal edema, acute tracheobronchitis, chemical pneumonia. Contact with the liquid can result in frostbite burns of the skin and eyes [Genium 1992].

2. Chronic exposure: Chronic exposure to low levels of chlorine gas can result in a dermatitis known as chloracne, tooth enamel corrosion, coughing, severe chest pain, sore throat, hemoptysis and increased susceptibility to tuberculosis [Genium 1992].

EMERGENCY MEDICAL PROCEDURES

* Emergency medical procedures: [NIOSH to supply]

5. Rescue: Remove an incapacitated worker from further exposure and implement appropriate emergency procedures (e.g., those listed on the Material Safety Data Sheet required by OSHA's Hazard Communication Standard [29 CFR 1910.1200]). All workers should be familiar with emergency procedures, the location and proper use of emergency equipment, and methods of protecting themselves during rescue operations.

EXPOSURE SOURCES AND CONTROL METHODS

The following operations may involve chlorine and lead to worker exposuresto this substance:

* The manufacture and transportation of chlorine

Use as a chlorinating and oxidizing agent in organic and inorganic synthesis; in the manufacture of chlorinated solvents, automotive antifreeze and antiknock compounds, polymers (synthetic rubber and plastics), resins, elastomers, pesticides, refrigerants, and in the manufacture of rocket fuel

Use as a fluxing, purification, and extraction agent in metallurgy

Use as a bacteriostat, disinfectant, odor control, and demulsifier in treatment of drinking water, swimming pools, and in sewage

Use in the paper and pulp, and textile industries for bleaching cellulose for artificial fibers; use in the manufacture of chlorinated lime; use in detinning and dezincing iron; use to shrink-proof wool

Use in the manufacture of pharmaceuticals, cosmetics, lubricants, flameproofing, adhesives, in special batteries containing lithium or zinc, and in hydraulic fluids; use in the processing of meat, fish, vegetables, and fruit

Use as bleaching and cleaning agents, and as a disinfectant in laundries, dishwashers, cleaning powders, cleaning dairy equipment, and bleaching cellulose

Methods that are effective in controlling worker exposures to chlorine,depending on the feasibility of implementation, are as follows:

* Process enclosure Local exhaust ventilation General dilution ventilation Personal protective equipment

Workers responding to a release or potential release of a hazardous substance must be protected as required by paragraph (q) of OSHA's Hazardous Waste Operations and Emergency Response Standard [29 CFR

Good sources of information about control methods are as follows:

1. ACGIH [1992]. Industrial ventilation--a manual of recommended practice. 21st ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.

2. Burton DJ [1986]. Industrial ventilation--a self study companion. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.

3. Alden JL, Kane JM [1982]. Design of industrial ventilation systems. New York, NY: Industrial Press, Inc.

4. Wadden RA, Scheff PA [1987]. Engineering design for control of workplace hazards. New York, NY: McGraw-Hill.

5. Plog BA [1988]. Fundamentals of industrial hygiene. Chicago, IL: National Safety Council.

MEDICAL SURVEILLANCE

OSHA is currently developing requirements for medical surveillance. When these requirements are promulgated, readers should refer to them for additional information and to determine whether employers whose employees are exposed to chlorine are required to implement medical surveillance procedures.

* Medical Screening

Workers who may be exposed to chemical hazards should be monitored in a systematic program of medical surveillance that is intended to prevent occupational injury and disease. The program should include education of employers and workers about work-related hazards, early detection of adverse health effects, and referral of workers for diagnosis and treatment. The occurrence of disease or other work-related adverse health effects should prompt immediate evaluation of primary preventive measures (e.g., industrial hygiene monitoring, engineering controls, and personal protective equipment). A medical surveillance program is intended to supplement, not replace, such measures. To detect and control work-related health effects, medical evaluations should be performed (1) before job placement, periodically during the term of employment, and (3) at the time of job transfer or termination.

* Preplacement medical evaluation

Before a worker is placed in a job with a potential for exposure to chlorine, a licensed health care professional should evaluate and document the worker's baseline health status with thorough medical, environmental, and occupational histories, a physical examination, and physiologic and laboratory tests appropriate for the anticipated occupational risks. These should concentrate on the function and integrity of the skin, eyes, teeth, respiratory system, and cardiovascular system. Medical surveillance for respiratory disease should be conducted using the principles and methods recommended by the American Thoracic Society.

A preplacement medical evaluation is recommended to assess medical conditions that may be aggravated or may result in increased risk when a worker is exposed to chlorine at or below the prescribed exposure limit. The health care professional should consider the probable frequency, intensity, and duration of exposure as well as the nature and degree of any applicable medical condition. Such conditionswhich should not be regarded as absolute contraindications to job placement) include a history and other findings consistent with diseases of the skin, eyes, teeth, respiratory system, or cardiovascular system.

* Periodic medical evaluations

Occupational health interviews and physical examinations should be performed at regular intervals during the employment period, as mandated by any applicable Federal, State, or local standard. Where no standard exists and the hazard is minimal, evaluations should be conducted every 3 to 5 years or as frequently as recommended by an experienced occupational health physician. Additional examinations may be necessary if a worker develops symptoms attributable to chlorine exposure. The interviews, examinations, and medical screening tests should focus on identifying the adverse effects of chlorine on the skin, eyes, teeth, respiratory system, or cardiovascular system. Current health status should be compared with the baseline health status of the individual worker or with expected values for a suitable reference population.

* Termination medical evaluations

The medical, environmental, and occupational history interviews, the physical examination, and selected physiologic or laboratory tests that were conducted at the time of placement should be repeated at the time of job transfer or termination to determine the worker's medical status at the end of his or her employment. Any changes in the worker's health status should be compared with those expected for a suitable reference population.

* Biological monitoring

Biological monitoring involves sampling and analyzing body tissues or fluids to provide an index of exposure to a toxic substance or metabolite. No biological monitoring test acceptable for routine use has yet been developed for chlorine.

WORKPLACE MONITORING AND MEASUREMENT

Determination of a worker's exposure to airborne chlorine is made using amidget fritted glass bubbler (MFGB) containing a 0.1 percent solution of sulfamic acid. Samples are collected at a maximum flow rate of 1.0 liter/minute until a maximum collection volume of 15 liters is collected for short-term (STEL or ceiling) samples, or 300 liters is collected forTWA samples. Analysis is conducted using an ion specific electrode (ISE). This method is described in the OSHA Computerized Information System [OSHA and is fully validated. NIOSH Method No. 6011 (for chlorine or bromine) can also be used for the determination of a worker's exposure toairborne chlorine. This method requires sample collection on a silvermembrane filter using flow rates of between 0.3 and 1.0 liter/minute until a minimum collection volume of 2 liters or a maximum collection volume of liters is reached. Analysis for this method is conducted using ionchromatography [NIOSH 1994].

PERSONAL HYGIENE PROCEDURES

If chlorine contacts the skin, workers should flush the affected areasimmediately with plenty of water, followed by washing with soap and water.

Clothing contaminated with chlorine should be removed immediately, and provisions should be made for the safe removal of the chemical from the clothing. Persons laundering the clothes should be informed of the hazardous properties of chlorine, particularly its potential for causing severe irritation to the eyes, skin, and mucous membranes.

A worker who handles chlorine should thoroughly wash hands, forearms, and face with soap and water before eating, using tobacco products, using toilet facilities, applying cosmetics, or taking medication.

Workers should not eat, drink, use tobacco products, apply cosmetics, or take medication in areas where chlorine or a solution containing chlorine is handled, processed, or stored.

STORAGE

Chlorine should be stored in a cool, dry, well-ventilated area in tightly sealed containers that are labeled in accordance with OSHA's Hazard Communication Standard [29 CFR 1910.1200]. Containers of chlorine should be protected from exposure to weather, extreme temperatures changes, and physical damage, and they should be stored separately from flammable gases and vapors, combustible substances (such as gasoline and petroleum products, hydrocarbons, turpentine, alcohols, acetylene, hydrogen, ammonia,and sulfur), reducing agents, finely divided metals, arsenic, bismuth, boron, calcium, activated carbon, carbon disulfide, glycerol, hydrazine, iodine, methane, oxomonosilane, potassium, propylene, silicon, hydrogen sulfide and water, carbon monoxide and sulfur dioxide, moisture, steam, and water. Workers handling and operating chlorine containers, cylinders, andtank wagons should receive special training in standard safety procedures for handling compressed corrosive gases. All pipes and containment used for chlorine service should be regularly inspected and tested. Empty containers of chlorine should have secured protective covers on their valves and should be handled appropriately.

SPILLS AND LEAKS

In the event of a spill or leak involving chlorine, persons not wearing protective equipment and fully-encapsulating, vapor-protective clothing should be restricted from contaminated areas until cleanup has been completed. The following steps should be undertaken following a spill or leak:

1. Notify safety personnel.

2. Remove all sources of heat and ignition.

3. Keep all combustibles (wood, paper, oil, etc.) away from the leak.

4. Ventilate potentially explosive atmospheres.

5. Evacuate the spill area for at least 50 feet in all directions.

6. Find and stop the leak if this can be done without risk; if not, move the leaking container to an isolated area until gas has dispersed. The cylinder may be allowed to empty through a reducing agent such as sodium bisulfide and sodium bicarbonate.

7. Use water spray to reduce vapors; do not put water directly on the leak or spill area.

SPECIAL REQUIREMENTS

U.S. Environmental Protection Agency (EPA) requirements for emergency planning, reportable quantities of hazardous releases, community right-to-know, and hazardous waste management may change over time. Usersare therefore advised to determine periodically whether new information is available.

* Emergency planning requirements

Employers owning or operating a facility at which there are 100 pounds or more of chlorine must comply with EPA's emergency planning requirements [40 CFR Part 355.30].

* Reportable quantity requirements for hazardous releases

A hazardous substance release is defined by EPA as any spilling, leaking, pumping, pouring, emitting, emptying, discharging, injecting, escaping, leaching, dumping, or disposing into the environmentincluding the abandonment or discarding of contaminated containers) of hazardous substances. In the event of a release that is above the reportable quantity for that chemical, employers are required to notify the proper Federal, State, and local authorities [40 CFR

The reportable quantity of chlorine is 10 pounds. If an amount equal to or greater than this quantity is released within a 24-hour period in a manner that will expose persons outside the facility, employers are required to do the following:

Notify the National Response Center immediately at (800) or at (202) 426-2675 in Washington, D.C. [40 CFR 302.6]. Notify the emergency response commission of the State likely to be affected by the release [40 CFR 355.40]. Notify the community emergency coordinator to the local emergency planning committee (or relevant local emergency response personnel) of any area likely to be affected by the release [40

CFR 355.40].

* Community right-to-know requirements

Employers who own or operate facilities in SIC codes 20 to 39 that employ 10 or more workers and that manufacture 25,000 pounds or more of chlorine per calendar year or otherwise use 10,000 pounds or more of chlorine per calendar year are required by EPA [40 CFR Part 372.30] to submit a Toxic Chemical Release Inventory form (Form R) to EPA reporting the amount of chlorine emitted or released from their facility annually.

* Hazardous waste management requirements

EPA considers a waste to be hazardous if it exhibits any of the following characteristics: ignitability, corrosivity, reactivity, or toxicity as defined in 40 CFR 261.21-261.24. Under the Resource Conservation and Recovery Act (RCRA) [40 USC 6901 et seq.], EPA has specifically listed many chemical wastes as hazardous. Although chlorine is not specifically listed as a hazardous waste under RCRA, EPA requires employers to treat waste as hazardous if it exhibits any of the characteristics discussed above.

Providing detailed information about the removal and disposal of specific chemicals is beyond the scope of this guideline. The U.S. Department of Transportation, EPA, and State and local regulations should be followed to ensure that removal, transport, and disposal of this substance are conducted in accordance with existing regulations. To be certain that chemical waste disposal meets EPA regulatory requirements, employers should address any questions to the RCRA hotline at (703) 412-9810 (in the Washington, D.C. area) or toll-free at (800) 424-9346 (outside Washington, D.C.). In addition, relevant State and local authorities should be contacted for information on any requirements they may have for the waste removal and disposal of this substance.

RESPIRATORY PROTECTION

* Conditions for respirator use

Good industrial hygiene practice requires that engineering controls be used where feasible to reduce workplace concentrations of hazardous materials to the prescribed exposure limit. However, some situations may require the use of respirators to control exposure. Respirators must be worn if the ambient concentration of chlorine exceeds prescribed exposure limits. Respirators may be used (1) before engineering controls have been installed, (2) during work operations such as maintenance or repair activities that involve unknown exposures, (3) during operations that require entry into tanks or closed vessels, and (4) during emergencies. Workers should only use

respirators that have been approved by NIOSH and the Mine Safety and Health Administration (MSHA).

* Respiratory protection program

Employers should institute a complete respiratory protection program that, at a minimum, complies with the requirements of OSHA's Respiratory Protection Standard [29 CFR 1910.134]. Such a program must include respirator selection, an evaluation of the worker's ability to perform the work while wearing a respirator, the regular training of personnel, respirator fit testing, periodic workplace monitoring, and regular respirator maintenance, inspection, and cleaning. The implementation of an adequate respiratory protection program (including selection of the correct respirator) requires that a knowledgeable person be in charge of the program and that the program be evaluated regularly. For additional information on the selection and use of respirators and on the medical screening of respirator users, consult the latest edition of the NIOSH Respirator Decision Logic [NIOSH 1987b] and the NIOSH Guide to Industrial Respiratory Protection [NIOSH 1987a].

PERSONAL PROTECTIVE EQUIPMENT

Workers should use appropriate personal protective clothing and equipmentthat must be carefully selected, used, and maintained to be effective in preventing skin contact with chlorine. The selection of the appropriate personal protective equipment (PPE) (e.g., gloves, sleeves, encapsulating suits) should be based on the extent of the worker's potential exposure to chlorine. The resistance of various materials to permeation by both chlorine liquid and chlorine gas is shown below:

Material Breakthrough time (hr) Chlorine liquid responder

Chlorine gas butyl rubber neoprene teflon viton saranex barricade chemrel responder trellchem HPS nitrile rubberH (PE/EVAL) polyethylene polyvinyl chloride

Material is estimated (but not tested) to provide at least four hours of protection. Not recommended, degradation may occur.

To evaluate the use of these PPE materials with chlorine, users should consult the best available performance data and manufacturers' recommendations. Significant differences have been demonstrated in the chemical resistance of generically similar PPE materials (e.g., butyl) produced by different manufacturers. In addition, the chemical resistance of a mixture may be significantly different from that of any of its neat components.

Any chemical-resistant clothing that is used should be periodically evaluated to determine its effectiveness in preventing dermal contact. Safety showers and eye wash stations should be located close to operations that involve chlorine.

Splash-proof chemical safety goggles or face shields (20 to 30 cm long, minimum) should be worn during any operation in which a solvent, caustic, or other toxic substance may be splashed into the eyes.

In addition to the possible need for wearing protective outer apparel e.g., aprons, encapsulating suits), workers should wear work uniforms, coveralls, or similar full-body coverings that are laundered each day. Employers should provide lockers or other closed areas to store work andstreet clothing separately. Employers should collect work clothing at theend of each work shift and provide for its laundering. Laundry personnelshould be informed about the potential hazards of handling contaminatedclothing and instructed about measures to minimize their health risk.

Protective clothing should be kept free of oil and grease and should be inspected and maintained regularly to preserve its effectiveness.

Protective clothing may interfere with the body's heat dissipation, especially during hot weather or during work in hot or poorly ventilated work environments.

REFERENCES

ACGIH [1991]. Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.

ACGIH [1994]. 1994-1995 Threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.

ATS [1987]. Standardization of spirometry -- 1987 update. American Thoracic Society. Am Rev Respir Dis

CFR. Code of Federal regulations. Washington, DC: U.S. Government Printing Office, Office of the Federal Register.

Clayton G, Clayton F [1981-1982]. Patty's industrial hygiene and toxicology. 3rd rev. ed. New York, NY: John Wiley & Sons.

DOT [1993]. 1993 Emergency response guidebook, guide 20. Washington, DC: U.S. Department of Transportation, Office of Hazardous Materials Transportation, Research and Special Programs Administration.

Forsberg K, Mansdorf SZ [1993]. Quick selection guide to chemical protective clothing. New York, NY: Van Nostrand Reinhold.

Genium [1992]. Material safety data sheet No. 53. Schenectady, NY: Genium Publishing Corporation.

Grant WM [1986]. Toxicology of the eye. 3rd ed. Springfield, IL: Charles C Thomas.

Hathaway GJ, Proctor NH, Hughes JP, and Fischman ML [1991]. Proctor and Hughes' chemical hazards of the workplace. 3rd ed. New York, NY: Van Nostrand Reinhold.

Lewis RJ, ed. [1993]. Lewis condensed chemical dictionary. 12th ed. New York, NY: Van Nostrand Reinhold Company.

Lide DR [1993]. CRC handbook of chemistry and physics. 73rd ed. Boca Raton, FL: CRC Press, Inc.

Mickelsen RL, Hall RC [1987]. A breakthrough time comparison of nitrile and neoprene glove materials produced by different glove manufacturers. Am Ind Hyg Assoc J 941-947

Mickelsen RL, Hall RC, Chern RT, Myers JR [1991]. Evaluation of a simple weight-loss method for determining the permeation of organic liquids through rubber films. Am Ind Hyg Assoc J 445-447

NFPA [1986]. Fire protection guide on hazardous materials. 9th ed. Quincy, MA: National Fire Protection Association.

NIOSH [1987a]. NIOSH guide to industrial respiratory protection. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 87-116.

NIOSH [1987b]. NIOSH respirator decision logic. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 87-108.

NIOSH [1992]. Recommendations for occupational safety and health: Compendium of policy documents and statements. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 92-100.

NIOSH [1994]. NIOSH manual of analytical methods. 4th ed. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 94-113.

NIOSH [1995]. Registry of toxic effects of chemical substances: Chlorine. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, Technical Information Branch.

NJDH [1992]. Hazardous substance fact sheet: Chlorine. Trenton, NJ: New Jersey Department of Health.

NLM [1995]. Hazardous substances data bank: Chlorine. Bethesda, MD: National Library of Medicine.