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Safety and Health Topics: |
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| Manganese Compounds (as Mn) |
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General Description
OSHA IMIS Code Number: M112
Chemical Abstracts Service (CAS) Registry Number: 7439-96-5
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: OO9275000
NIOSH Pocket Guide to Chemical Hazards, Manganese compounds and fume (as Mn): chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 5 mg/m3 Ceiling
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 5 mg/m3 Ceiling
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 5 mg/m3 Ceiling
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.2 mg/m3 TWA (TLV listed as Manganese and inorganic compounds, as Mn)
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1 mg/m3 TWA; 3 mg/m3 STEL
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 mg Mn/m3
Potential symptoms: Irritation eyes, skin, respiratory system; eye, skin burns (from prolonged direct contact with dust or concentrated liquid); conjunctivitis; blindness; dermatitis; cough, chest tightness, dyspnea, rales; pulmonary edema; bronchitis, pneumonitis; anorexia, weakness, sleepiness; parkinsonism (gait disturbances, clumsiness, tremor, speech disturbances, mask-like facial expression, and personality changes); kidney damage, liver damage; methemoglobinemia, anemia (from manganese nitrate); INGES ACUTE (50% manganese nitrate solution): Burning sensation, mouth, throat; abdominal pain, nausea, vomiting, diarrhea; convulsions; collapse (can be fatal).
Health Effects: Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15); Cumulative CNS damage (HE7); Lung damage---Acute (HE11) and Cumulative (HE10).
Affected organs: Respiratory system, CNS, blood, kidneys.
Notes: 1) Inhalational toxicokinetic studies with rats indicate achievement of higher brain levels of manganese with Mn phosphate or Mn phosphate/sulfate mixture than with metallic Mn dust. 2) One Mn-containing compound, mangafodipir trisodium, is used intravenously in radiology as a liver contrast agent. A study in dogs reported that some Mn in this agent may be redistributed to the brain and adrenals under certain circumstances. 3) Chronic exposure to a Mn-containing fungicide (maneb) was reported to cause parkinsonism.
Date Last Revised: 06/22/2004
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Manganese compounds and fume (as Mn).
- EPA Air Toxics Website: Manganese Compounds. U.S. Environmental Protection Agency Technology Transfer Network
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- Grant, D., Toft, K.G., Martinsen, I. and Atzpodien, E.: Tissue distribution and general safety of MnDPDP in male beagle dogs, with or without total common bile duct obstruction. Acta Radiol. 38(4 Pt. 2): 732-739, 1997.
- Meco, G., Bonifati, V., Vanacore, N. and Fabrizio, E.: Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate). Scand. J. Work Environ. Health 20(4): 301-305, 1994.
- Mineral Research and Development (Charlotte, NC): Material Safety Data Sheet: Manganese (II) Nitrate Solution (Jan. 30, 2003) 8 pp.
- Normandin, L., et al.: Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese. Neurotoxicology 25(3): 433-441, 2004.
- Pohanish, R.P. (editor): Manganese Nitrate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1448-1450.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Mixed Cellulose Ester Filter (MCEF) 0.8 microns
maximum volume: 960 Liters minimum volume: 480 Liters
maximum flow rate: 2.0 L/min (TWA)
maximum volume: 30 Liters maximum flow rate: 2.0 L/min (STEL)
maximum volume: 10 Liters minimum time: 5 Minutes
maximum flow rate: 2.0 L/min (Ceiling)
current analytical method: Atomic Absorption Spectroscopy; AAS
method reference: OSHA Analytical Method (OSHA 121)
method classification: Fully Validated
alternative analytical method: Inductively Coupled Argon Plasma; ICP/DCP-AES
method reference: OSHA Analytical Method (OSHA 125G)
method classification: Fully Validated
note: Samples may be collected up to an 8 hour period, if the filter is not overloaded. When analysis of a compound is requested, an elemental analysis is performed and reported as the element.
* All Trademarks are the property of their respective owners.
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