FYI from the NHLBI Index

May 2007: Vol. 8, Issue 1
Research and Resources

Animal Stem Cell Research: Novel Approaches to Enhance
Ataxia-Telangiectasia: Understanding and Treating
Bioengineering and Obesity
Bioengineering research Partnerships
Children and Adolescents: Chronic Illness Self-Management
Critical Care: Multidisciplinary Translational Research
Diet Composition and Energy Balance
Heart Failure: Improving Disease Management
Hyperglycemic Exacerbation of Ischemia/Reperfusion Injury after Ischemic Insult
Hypersensitivity Pneumonitis: Early Identification and Mechanisms of Disease
Metabolomics: Application for Translational and Biological Research
Nanoscience and Nanotechnology in Biology and Medicine
NHLBI Career Transition Award (K22)
Occupational Safety and Health
Organ Transplantation in Children: Clinical Trials
Software Development and Maintenance
Stress Management Interventions to Reduce Risk of Coronary Artery Disease

NHLBI Research Initiatives

From time to time, the NHLBI invites investigators to submit grant applications or contract proposals for specific research programs. We are currently soliciting applications for the programs described below. Please visit the URL listed with each program to obtain information about important application dates and deadlines. For full details of these and other research initiatives, visit www.nhlbi.nih.gov/funding/inits/index.htm.

Animal Stem Cell Research: Novel Approaches to Enhance

Initiative Number: PA-07-303/304
Objective: Enhance animal stem cells as model biological systems for the study of biological and disease processes, for the development of therapeutics, and for the development of replacement tissues, through understanding of control of cellular differentiation.

Ataxia-Telangiectasia: Understanding and Treating

Initiative Number: PA-07-272/273
Objective: Conduct basic and translational studies to determine how symptoms of ataxia-telangiectasia (AT) develop, to stimulate the development of resources to further AT research, to accelerate research into promising therapeutic approaches for AT, and to stimulate progress in AT research through encouraging and facilitating interdisciplinary interactions.

Bioengineering and Obesity

Initiative Number: PA-07-354
Objective: Develop and validate new and innovative engineering approaches to address clinical problems related to energy balance, intake, and expenditure. This PA using the R01 funding mechanism runs in parallel with an RFA of identical scientific scope using the R21 funding mechanism.

Bioengineering Research Partnerships

Initiative Number: PAR-07-352
Objective: Apply integrated, multidisciplinary, systems approaches to significant areas of basic bioengineering research and encourage collaborations and partnerships among the allied quantitative and biomedical disciplines.

Children and Adolescents: Chronic Illness Self-Management

Initiative Number: PA-07-097/098/099
Objective: Improve self-management and quality of life in children and adolescents ages 8 to 21 with chronic illnesses. Biobehavioral studies of children in the context of family and family-community dynamics are encouraged.

Critical Care: Multidisciplinary Translational Research

Initiative Number: PA-07-233
Objective: Conduct interdisciplinary translational research on the care of high-risk, critically ill patients in intensive care units.

Diet Composition and Energy Balance

Initiative Number: PA-07-218
Objective: Investigate the role of diet composition in energy balance, in both animals and humans. Collaborations between basic and clinical researchers are particularly encouraged.

Heart Failure: Improving Disease Management

Initiative Number: PA-07-355
Objective: Identify and disseminate clinically effective disease management tools into clinical practice to reduce heart failure morbidity and mortality and improve patient outcomes.

Hyperglycemic Exacerbation of Ischemia/Reperfusion Injury after Ischemic Insult

Initiative Number: PA-07-323
Objective: Clarify the mechanisms whereby elevated blood glucose increases myocardial ischemia and reperfusion injury following an acute ischemic insult.

Hypersensitivity Pneumonitis: Early Identification and Mechanisms of Disease

Initiative Number: PA-07-300
Objective: Investigate basic mechanisms and early clinical identification of hypersensitivity pneumonitis interstitial lung disease in order to elucidate how chronic disease progresses and how it can evolve into either interstitial fibrosis or airway obstructive disease (emphysema).

Metabolomics: Application for Translational and Biological Research

Initiative Number: PA-07-301/302
Objective: Apply metabolomic technologies for translational research in human health and disease to enable and improve disease detection, diagnosis, risk assessment, prognosis, and prediction of therapeutic responses.

Nanoscience and Nanotechnology in Biology and Medicine

Initiative Number: PAR-07-270/271
Objective: Carry out biological and medical research and development on the understanding and control of matter at the atomic, molecular, or macromolecular levels, at a length scale of approximately 1 – 100 nanometers, where novel properties and functions occur because of the size.

NHLBI Career Transition Award (K22)

Initiative Number: PAR-07-317
Objective: Enable outstanding students with three to five years of postdoctoral training to obtain a research training experience in the NHLBI Division of Intramural Research and facilitate their successful transition to an extramural environment as independent researchers.

Occupational Safety and Health

Initiative Number: PA-07-318
Objective: Develop an understanding of the risks and conditions that are associated with occupational diseases and injuries, explore methods for reducing risks and for preventing or minimizing exposure to hazardous conditions in the workplace, and translate significant scientific findings into prevention practices and products that will effectively reduce work-related illnesses and injuries.

Organ Transplantation in Children: Clinical Trials

Initiative Number: RFA-AI-07-006
Objective: Improve graft acceptance and patient/graft survival in patients up to 20 years of age who have undergone heart, lung, liver, kidney or intestinal transplantation.

Software Development and Maintenance

Initiative Number: PAR-07-235
Objective: Improve, evaluate, and test existing informatics and computational biology software programs that originated in biomedical research laboratories in order to extend their applicability to the broader biomedical research community of translational and clinical researchers.

Stress Management Interventions to Reduce Risk of Coronary Artery Disease

Initiative Number: PA-07-322
Objective: Evaluate the effects of stress management interventions on intermediate outcomes purported to be in the biological or behavioral mechanistic pathway through which mental stress is thought to influence major adverse cardiac events in patients with confirmed coronary artery disease.

Modified 5/22/07
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Elizabeth G. Nabel, M.D.
Director, NHLBI

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