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NHLBI Funds Pediatric Heart Disease Clinical Centers
Spotlight on Our Web Site
NHLBI Research Initiatives
- Asthma Exacerbations: Biology and Disease Progression
- Biological Basis of Hutchinson-Gilford Syndrome: Relationship to Mutations
in the Lamin A/C Gene and to Other Known Laminopathies
- Chemical Screens for New Inducers of Fetal Hemoglobin (SBIR/STTR)
- Chronic Illness Self-Management in Children
- Exploratory and Developmental Research Grants for Investigations in
Rare Diseases (R21)
- Idiopathic Pulmonary Fibrosis Clinical Research Network
- NHLBI Programs of Excellence in Nanotechnology
- Pathogenesis and Treatment of Lymphedema and Lymphatic Diseases
- Pulmonary Complications of Sickle Cell Disease
- Sleep Disturbance in Parkinson's Disease and Parkinson-like Conditions
- Specialized Centers of Clinically Oriented Research (SCCOR) in Hemostatic
and Thrombotic Diseases
- SCCOR in Transfusion Biology and Medicine
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NHLBI Funds Pediatric Heart Disease Clinical Centers
The
NHLBI recently awarded $68 million to fund four clinical centers to accelerate
research on heart development and treatment of pediatric heart disease. The
research is part of the Specialized Centers of Clinically Oriented Research
program, which is designed to stimulate multidisciplinary collaborations so
that basic research advances can be rapidly translated to clinical care.
Birth defects are a leading cause of infant mortality,
with cardiovascular malformations, which are present in
about one percent of live births, being the largest contributors
to deaths from birth defects.
The Centers will encourage experts, including pediatric cardiologists, cardiovascular
surgeons, immunologists, geneticists, pediatric clinicians, molecular biologists,
cell biologists, and statisticians, to combine their talents to conduct state-of-the-art
research addressing a central pediatric cardiovascular theme. The Centers will
be located in Boston, Philadelphia, Pittsburgh, and Cincinnati.
Spotlight on Our Web Site
The
Garfield Star Sleeper Campaign has teamed up with Time for Kids to help
children learn about the importance of getting at least nine hours of sleep
each night. Time for Kids is a subsidiary of Time, Inc. that provides materials
for use in classrooms.
During National Sleep Awareness Week, March 29-April 4, nearly 30,000 third
grade teachers received a teacher's guide and "Be a Star Sleeper"
magazines for their approximately 750,000 students. Download a free
copy of the materials.
NHLBI Research Initiatives
From time to time, the NHLBI invites investigators to submit grant applications
or contract proposals for specific research programs. We are currently soliciting
applications for the programs described below. For a full details of these and
other research initiatives, visit www.nhlbi.nih.gov/funding/inits/index.htm
or the Web page that is linked each initiative number.
Asthma Exacerbations: Biology and Disease Progression
- Initiative Number: RFA-HL-04-029
- Applications due: June 18, 2004
- Objective: To explore the underlying pathobiology and mechanisms
of resolution of exacerbations, and their impact on lung function, physiology,
and disease state.
Biological Basis of Hutchinson-Gilford Syndrome:
Relationship to Mutations in the Lamin A/C Gene and to Other Known Laminopathies
- Initiative Number: PA-03-069
- Applications are accepted for February 1, June 1, and October 1 deadlines
each year.
- Objective: To understand how mutations in the gene for lamin A/C
affect nuclear structure, thus leading to both dysfunction of the nuclear
envelope, and depending on the mutation, Hutchinson-Gilford syndrome.
Chemical Screens for New Inducers of Fetal Hemoglobin (SBIR/STTR)
- Initiative Number: PA-03-049
- Applications due: April 1, August 1, and December 1
- Objective: To develop drugs that increase fetal hemoglobin levels for the treatment of
beta-chain hemoglobinopathies such as sickle cell disease and Cooley's anemia (beta-thalassemia).
Chronic Illness Self-Management in Children
- Initiative Number: PA-03-159
- Applications are accepted for February 1, June 1, and October 1 deadlines
each year.
- Objective: To support research related to sociocultural, environmental, and behavioral mechanisms as well as
biological/technological factors that improve self-management and quality
of life in children and adolescents with chronic diseases.
Exploratory and Developmental Research Grants for Investigations in Rare
Diseases (R21)
- Initiative Number:
PA-03-171
- Applications are accepted for February 1, June 1, and October 1 deadlines
each year.
- Objective: To encourage new approaches to understanding, treating, and preventing rare diseases in the areas of heart, lung, and
blood disease and sleep disorders.
Idiopathic Pulmonary Fibrosis Clinical Research Network
- Initiative Number:
RFA-HL-04-021
- Applications due: June 21, 2004
- Objective: To establish a clinical research network and data coordinating center to conduct
multiple treatment trials on patients with newly diagnosed idiopathic pulmonary fibrosis.
NHLBI Programs of Excellence in Nanotechnology
- Initiative Number:
RFA-HL-04-020
- Applications due: July 21, 2004
- Objective: To develop and apply nanotechnology and nanoscience solutions to the diagnosis and
treatment of cardiovascular, pulmonary, hematopoietic, and sleep disorders through the establishment of
multidisciplinary teams.
Pathogenesis and Treatment of Lymphedema and Lymphatic Diseases
- Initiative Number: PA-04-071
- Applications are accepted for February 1, June 1, and October 1 deadlines
each year.
- Objectives: to stimulate research on the biology of the lymphatic system, to characterize the
pathophysiologic mechanisms that cause the disease, to develop new methods for quantitating and imaging lymph flow,
to discover new therapeutic interventions, and to determine the safety and efficacy of complementary and alternative therapies.
Pulmonary Complications of Sickle Cell Disease
- Initiative Number: RFA-HL-04-015
- Applications due: May 24, 2004
- Objective: To stimulate translational research on the pulmonary complications of sickle cell disease.
Sleep Disturbance in Parkinson's Disease and Parkinson-like Conditions
- Initiative Number:
PAS-03-131
- Applications are accepted for February 1, June 1, and October 1 deadlines
each year.
- Objective: To stimulate research on sleep disorders in Parkinson's disease and Parkinson's related neurological conditions, and on associated
sleep disorders such as Restless Legs Syndrome and sleep-disordered breathing.
Specialized Centers of Clinically Oriented Research (SCCOR) in Hemostatic
and Thrombotic Diseases
- Initiative Number:
RFA-04-016
- Applications due: September 21, 2004
- Objective: To foster multidisciplinary research that enables basic science findings to be more
rapidly applied to the prevention, diagnosis, and treatment of thrombotic and bleeding disorders.
SCCOR in Transfusion Biology and Medicine
- Initiative Number: RFA-HL-04-018
- Applications due: September 21, 2004
- Objectives: To support the development and application of new knowledge
essential for improved safety, efficacy, and availability of blood, blood components,
and plasma derivatives, and to transfer these findings into clinical evaluation
and application.
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