National Toxicology Program

CASRN: 76-06-2

Formula: C-CL3-N-O2

Synonyms/Common Names:

• TRICHLORONITROMETHANE

Known Uses:

FUMIGANT; FUNGICIDE; INSECTICIDE; ORGANIC SYNTHESIS; DYES; TEAR GAS

Short-Term Toxicity

• 14-Day (Gavage)  (C00533) Completed 
  • NTIS No. PB282311  (Peer Review 01/18/1978)
    Citation: Bioassay of Chloropicrin for Possible Carcinogenicity (CAS No. 76-06-2)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Gavage)  (C00533) Completed 
  • NTIS No. PB282311  (Peer Review 01/18/1978)
    Citation: Bioassay of Chloropicrin for Possible Carcinogenicity (CAS No. 76-06-2)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,16,100, M: 0,10,63 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C00533) Report Complete 
  • TR-065 (NTIS No. PB282311)  (Peer Review 01/18/1978)
    Bioassay of Chloropicrin for Possible Carcinogenicity (CAS No. 76-06-2)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Inadequate Study 
  • Female Rats Inadequate Study 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: FR: 0,20,22 (AVG), MR: 0,25,26 (AVG), M: 0,33,36 (AVG) MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (405202) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (149367) Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
• Salmonella  (643495) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive 
• Salmonella  (678673) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive