FABP4 Protein and Assays
FABP4—a new therapeutic target for obesity and diabetes
Cayman Chemical is a leading provider of high-purity, active Fatty Acid Binding Proteins. Contact our sales staff for quotations on bulk preparations of FABP4 and FABP4 assay kits for your drug discovery efforts.
All FABP4 products from Cayman Chemical…
4E-BP1—a key regulator of protein translation
Cayman's two new immunometric (i.e., sandwich) assays are designed to accurately detect human Phospho-Thr37/Thr46 4E-BP1 and total 4E-BP1 in cell culture lysates.
Full information for 4E-BP1 EIA Kits...
SIRT Recombinant Proteins
Source:
recombinant N-terminal GST-tagged SIRT1 amino acids 193-747 purified from E. coli
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Mr:
89.2 kDa
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Source:
recombinant N-terminal Hexahistidine-tagged SIRT3 amino acids 101-399 purified from E. coli
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Mr:
33.5 kDa
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A competitive EIA for quantification of 8-OH-2dG
Cayman’s 8-OH-dG EIA is a competitive assay that can be used for the quantification of 8-OH-dG in urine, cell culture, plasma, and other sample matrices. The EIA utilizes an anti-mouse IgG-coated plate and a tracer consisting of an 8-OH-dG-enzyme conjugate. This …
Cayman’s Apoptotic Blebs Assay Kit employs a recombinant protein containing single-chain variable fragments (scFv) of D56R fused to the protein A domain B fraction as an antibody for apoptotic blebs. The protein A portion of this fusion protein is recognized and visualized by fluorescein-conjugated …
A convenient fluorescence-based method for screening LSD1-specific inhibitors
Cayman’s LSD1 Inhibitor Screening Assay Kit provides a convenient fluorescence-based method for screening LSD1-specific inhibitors. The assay is based on the multistep enzymatic reaction in which LSD1 first produces H2O2 during the demethylation of lysine 4 on a peptide …
96-Well assay for measurement of p53
Cayman’s p53 Transcription Factor Assay is a non-radioactive, sensitive method for detecting specific transcription factor DNA binding activity in nuclear extracts. A specific-double stranded DNA (dsDNA) sequence containing the p53 response element is immobilized onto the wells of a 96-well plate. …
An immune modulator that is a selective S1P1 receptor agonist
KRP 203 is a selective S1P1 receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. The phosphorylated form of KRP 203 demonstrates a high affinity for the S1P1 receptor with an ED50 value in the nM range and …
Designed for the convenient, precise quantification of 15-deoxy-Δ12,14-Prostaglandin J2
15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system. …
Designed for the convenient, precise quantification of Prostaglandin K2
Prostaglandin K2 (PGK2) is the 9,11-diketone formed by the oxidation of PGE2 or PGD2. Whether this compound exists biologically is uncertain; it is known to be resistant to metabolism by 15-hydroxy PGDH in vitro.
A synthetic intermediate useful for pharmaceutical synthesis
2-methylbenzamide Oxime is a synthetic intermediate useful for pharmaceutical synthesis.
A ω-3 fatty acid ethyl ester
DHA ethyl ester (DHA-EE) is the stabilized ethyl ester form of the ω-3 22:6 fatty acid. Dietary intake of DHA-EE enhances maze-learning ability in old mice. In rats, dietary DHA-EE increases plasma and erythrocyte membrane DHA levels without altering the content of the ω-6 …
Potent selective inhibitor of cGMP-dependent protein kinase (PKG)
KT 5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) (in vitro IC50 value = 234 nM). KT 5823 is cell-permeable and is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG …