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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap tRNA-Cys-1 IGR1590 IGR1591 IGR1589 IGR1588 IGR1592 rs2,rpsB, - SMu1847 tfs,tufA, - SMu1846 SMu1848 sacB,ftf, - SMu1843 clpC, - SMu1844 mccF, - SMu1849 rs2,rpsB, - SMu1847 tfs,tufA, - SMu1846 SMu1848 sacB,ftf, - SMu1843 clpC, - SMu1844 mccF, - SMu1849 rs2,rpsB, - SMu1847 tfs,tufA, - SMu1846 SMu1848 sacB,ftf, - SMu1843 clpC, - SMu1844 ctsR, - SMu1845 ctsR, - SMu1845 mccF, - SMu1849


LANL Gene ID: SMu1846

GenBank Locus Tag: SMU.2031c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
tfs  tufA  

Definition:
translation elongation factor Ts

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
1901428

Gene Stop:
1900382

Gene Length:
1047

Molecular Weight*:
37707

pI*:
4.70

Net Charge*:
-14.99

EC:
 

Functional Class:
Protein synthesis; Translation factors  

Gene Ontology:
Biological process
  GO:0006414    translational elongation

Cellular component
  GO:0005622    intracellular

Molecular function
  GO:0003746    translation elongation factor activity


Pathway: pathway table

Secondary Evidence:
Schmid,R., Bernhardt,J., Antelmann,H., Volker,A., Mach,H., Volker,U. and Hecker,M. Identification of vegetative proteins for a two-dimensional protein index of Bacillus subtilis. Microbiology 143 (Pt 3), 991-998 (1997) PubMed: 9084183.


Comment:
From GenBank (gi:13878479): In Lactococcus lactis, EF-TS associates with EF-TU - GDP complex and induces the exchange of GDP to GTP. This cytoplasmic protein remains bound to the aminoacyl-tRNA-EF-TU-GTP complex up until the GTP is hydrolysed on the ribosome. It belongs to the EF-TS family.



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Many strong matches in gapped BLAST to translation elongation factor Ts; residues 1-347 are 78% similar to translation elongation factor Ts of Streptococcus pyogenes (gi15675850); residues 1-347 are 80% similar to translation elongation factor Ts of Streptococcus pneumoniae (gi15904060).





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1831 (1e-156).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24380373|ref|NP_722328.1|  elongation factor Ts [Streptoc...   554   e-156
 gi|125718984|ref|YP_001036117.1|  Elongation factor Ts, puta...   468   e-130
 gi|157075400|gb|ABV10083.1|  translation elongation factor T...   467   e-130
 gi|116627033|ref|YP_819652.1|  Translation elongation factor...   466   e-130
 gi|55820176|ref|YP_138618.1|  elongation factor Ts [Streptoc...   464   e-129
 gi|50915126|ref|YP_061098.1|  elongation factor Ts [Streptoc...   463   e-129
 gi|22537970|ref|NP_688821.1|  elongation factor Ts [Streptoc...   463   e-129
 gi|15675850|ref|NP_270024.1|  elongation factor Ts [Streptoc...   457   e-127
 gi|21911319|ref|NP_665587.1|  elongation factor Ts [Streptoc...   456   e-127
 gi|56808419|ref|ZP_00366168.1|  COG0264: Translation elongat...   456   e-127


InterPro Summary:  InterProScan

InterPro
IPR000449
Domain
Ubiquitin-associated/Translation elongation factor EF1B, N-terminal
PF00627 [4-44]T 1.19999985703101E-7 PF00627 UBA UBA
InterPro
IPR001816
Family
Translation elongation factor EFTs/EF1B
PTHR11741 [7-215]T 3.4999946686394896E-70 PTHR11741 Transl_elong_EFTs/EF1B[234-340]T 3.4999946686394896E-70 PTHR11741 Transl_elong_EFTs/EF1B Transl_elong_EFTs/EF1B
TIGR00116 [1-344]T 0.0 TIGR00116 tsf tsf
PS01126 [12-27]T 8.0E-5 PS01126 EF_TS_1 EF_TS_1
PS01127 [75-85]T 8.0E-5 PS01127 EF_TS_2 EF_TS_2
InterPro
IPR009060
Domain
UBA-like
SSF46934 [2-55]T 1.4E-19 SSF46934 UBA_like UBA_like
InterPro
IPR014039
Domain
Translation elongation factor EFTs/EF1B, dimerisation
PF00889 [57-325]T 9.199984144203109E-54 PF00889 EF_TS EF_TS
SSF54713 [57-325]T 1.4E-42 SSF54713 EF_TS EF_TS
noIPR
unintegrated
unintegrated
G3DSA:1.10.8.30 [2-55]T 1.79999754022378E-17 G3DSA:1.10.8.30 G3DSA:1.10.8.30 G3DSA:1.10.8.30
G3DSA:3.30.479.20 [57-146]T 4.90001027782408E-21 G3DSA:3.30.479.20 G3DSA:3.30.479.20[152-324]T 5.999990440890849E-19 G3DSA:3.30.479.20 G3DSA:3.30.479.20 G3DSA:3.30.479.20


COGS Summary:  COGS Search
BeTs to 12 clades of COG0264
COG name: Translation elongation factor Ts
Functional Class: J
The phylogenetic pattern of COG0264 is -----qvcebrhujgpolinx
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB001816 (Elongation factor Ts) with a combined E-value of 1.1e-72.
    IPB001816A    9-55
    IPB001816B    73-89
    IPB001816C    130-143
    IPB001816D    180-205
    IPB001816E    261-290


 ProDom Summary:  Protein Domain Search
Residues 235-325 are 32% similar to a (ELONGATION FACTOR EF-TS BIOSYNTHESIS) protein domain (PD355203 which is seen in Q9KA64_BACHD.

Residues 8-200 are 24% similar to a (FACTOR TS ELONGATION) protein domain (PD208645 which is seen in O97235_PLAFA.

Residues 11-97 are 66% similar to a (ELONGATION FACTOR EF-TS BIOSYNTHESIS) protein domain (PD002210 which is seen in EFTS_LACLA.

Residues 140-231 are 67% similar to a (ELONGATION FACTOR EF-TS BIOSYNTHESIS) protein domain (PD106461 which is seen in EFTS_LACLA.

Residues 123-191 are 57% similar to a (FACTOR ELONGATION BIOSYNTHESIS EF-TS) protein domain (PD249321 which is seen in EFTS_BACSU.

Residues 237-329 are 72% similar to a (ELONGATION FACTOR EF-TS BIOSYNTHESIS) protein domain (PD337039 which is seen in EFTS_LACLA.

Residues 118-191 are 38% similar to a (FACTOR ELONGATION EF-TS BIOSYNTHESIS) protein domain (PD248236 which is seen in EFTS_RICPR.

Residues 98-139 are 71% similar to a (FACTOR ELONGATION EF-TS BIOSYNTHESIS) protein domain (PD375058 which is seen in EFTS_LACLA.

Residues 132-191 are 43% similar to a (FACTOR ELONGATION EF-TS BIOSYNTHESIS) protein domain (PD406595 which is seen in EFTS_CHLPN.

Residues 1-96 are 43% similar to a (FACTOR ELONGATION EF-TS BIOSYNTHESIS) protein domain (PD395995 which is seen in EFTS_PSEAE.


Paralogs:  Local Blast Search
SMu1846 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
Residues 4 to 44 (E-value = 5.9e-09) place SMu1846 in the UBA family which is described as UBA/TS-N domain (PF00627)
Residues 57 to 325 (E-value = 7.1e-79) place SMu1846 in the EF_TS family which is described as Elongation factor TS (PF00889)

 Top PDB Hits:
pdb1EFUB Chain B, Elongation Factor Complex Ef-TuEF-Ts From E... 177 1e-045
pdb1AIPC Chain C, Ef-Tu Ef-Ts Complex From Thermus Thermophil... 80 3e-016

Gene Protein Sequence:
MANITAALVKELREKTGAGVMDAKKALVEVEGDMGKAIELLREKGMAKAA
KKADRVAAEGLTGVYVDGNVAAIVEVNAETDFVAKNAQFVDLVNETAKVI
AEGKPANNEEALALKTAAGDTLEAAYVNATATIGEKISFRRFALVEKADK
QVFGAYQHNGGKIGVITVLEGENTDEALAKQLAMHVAAMNPSVLSYKELS
EEFIHDELAQMNHKIEQDNESRAMVDKPALPLLKYGSKGQLTDEVVAQAE
EDIKAELKAEGKPEKIWDKIIPGKMARFFLDNTKVDQQYTLLSQVYIMDD
SKTVEAYMESVNGKVISFVRFEVGEGIEKAANDFENEVAATMAAALNK

Gene Nucleotide Sequence:  Sequence Viewer
ATGGCAAATATTACTGCAGCTCTTGTTAAGGAATTGCGTGAAAAAACTGG
TGCTGGTGTCATGGACGCCAAAAAAGCCTTGGTTGAAGTTGAAGGCGATA
TGGGAAAAGCAATTGAACTTCTTCGCGAAAAAGGTATGGCCAAAGCAGCT
AAAAAAGCTGACCGTGTTGCCGCTGAAGGTTTAACAGGTGTTTATGTTGA
TGGCAATGTTGCCGCTATTGTGGAAGTTAATGCCGAAACCGATTTTGTTG
CTAAAAATGCTCAATTTGTTGACTTAGTCAATGAAACAGCTAAAGTTATC
GCTGAAGGTAAACCTGCTAACAATGAAGAAGCCCTTGCTTTAAAAACAGC
AGCTGGAGATACTTTAGAGGCTGCTTATGTCAATGCAACAGCAACCATTG
GAGAAAAAATTTCTTTCCGCCGTTTTGCTCTTGTTGAGAAAGCTGATAAA
CAAGTTTTCGGTGCCTACCAGCATAATGGTGGTAAGATTGGCGTTATCAC
GGTCCTTGAAGGTGAAAATACGGATGAAGCTCTTGCCAAACAACTTGCCA
TGCATGTTGCTGCAATGAACCCAAGTGTTCTTTCATACAAAGAATTGAGC
GAAGAATTTATTCATGATGAATTGGCTCAAATGAACCATAAAATTGAACA
AGATAATGAAAGCCGTGCTATGGTTGATAAACCAGCTCTTCCGCTTCTTA
AATACGGTTCAAAAGGTCAATTAACTGATGAAGTCGTTGCTCAAGCTGAA
GAAGATATCAAGGCAGAGCTTAAAGCTGAAGGCAAACCTGAAAAAATTTG
GGATAAAATCATTCCTGGTAAAATGGCTCGCTTCTTCTTGGACAATACGA
AGGTTGACCAACAATATACTTTGTTATCACAAGTTTACATTATGGATGAC
AGTAAGACTGTTGAAGCTTATATGGAATCCGTAAATGGGAAAGTGATTAG
CTTTGTTCGTTTTGAGGTCGGCGAAGGTATTGAAAAAGCAGCTAACGATT
TTGAAAATGAAGTTGCTGCAACCATGGCAGCTGCTCTTAATAAATAA

Los Alamos National Laboratory • Est 1943

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