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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR1441 IGR1436 IGR1435 IGR1433 IGR1437 IGR1438 IGR1439 IGR1434 aroH,aroG, - SMu1673 aroG, - SMu1672 alr, - SMu1670 SMu1666 recG, - SMu1669 SMu1668 uspA, - SMu1665 yhfU,bioB, - SMu1664 aspG,ansB, - SMu1667 aroH,aroG, - SMu1673 aroG, - SMu1672 alr, - SMu1670 SMu1666 recG, - SMu1669 SMu1668 uspA, - SMu1665 yhfU,bioB, - SMu1664 aspG,ansB, - SMu1667 aroH,aroG, - SMu1673 aroG, - SMu1672 alr, - SMu1670 SMu1666 recG, - SMu1669 acpS, - SMu1671 acpS, - SMu1671 SMu1668 uspA, - SMu1665 yhfU,bioB, - SMu1664 aspG,ansB, - SMu1667


LANL Gene ID: SMu1669

GenBank Locus Tag: SMU.1833c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
recG  

Definition:
ATP-dependent DNA helicase

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
1730310

Gene Stop:
1728295

Gene Length:
2016

Molecular Weight*:
75366

pI*:
8.80

Net Charge*:
4.91

EC:
 

Functional Class:
DNA metabolism; DNA replication, recombination, and repair  

Gene Ontology:
Biological process
  GO:0006281    DNA repair
  GO:0006310    DNA recombination

Molecular function
  GO:0003676    nucleic acid binding
  GO:0004003    ATP-dependent DNA helicase activity
  GO:0004386    helicase activity
  GO:0005524    ATP binding
  GO:0008026    ATP-dependent helicase activity


Pathway: pathway table

Secondary Evidence:
Gregg AV, McGlynn P, Jaktaji RP, Lloyd RG.
Direct Rescue of Stalled DNA Replication Forks via the Combined Action of PriA and RecG Helicase Activities.
Mol Cell. 2002 Feb;9(2):241-51.
PMID: 11864599

Dillingham MS, Kowalczykowski SC.
A step backward in advancing DNA replication: rescue of stalled replication forks by RecG.
Mol Cell. 2001 Oct;8(4):734-6.
PMID: 11684009

McGlynn P, Lloyd RG, Marians KJ.
Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled.
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8235-40.
PMID: 11459958


Comment:
For other 'rec' genes see SMu0021 (recO);SMu0532 (recN); SMu0545 (recR),(recM);SMu1956 (recF); SMu1892 (recA) ; SMu0425 (recU); SMu1705 (recD) and SMu1339 (recJ).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to recG proteins. Residues 1-671 are 76% similar to gi15675625 from S.pyogenes and 68% similar to gi15903582 from S.pneumoniae.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1682 (0.0).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24380195|ref|NP_722150.1|  putative ATP-dependent DNA hel...  1299   0.0  
 gi|77408999|ref|ZP_00785719.1|  ATP-dependent DNA helicase R...  1044   0.0  
 gi|77414524|ref|ZP_00790670.1|  ATP-dependent DNA helicase R...  1043   0.0  
 gi|22537822|ref|NP_688673.1|  ATP-dependent DNA helicase Rec...  1042   0.0  
 gi|139473203|ref|YP_001127918.1|  ATP-dependent DNA helicase...  1040   0.0  
 gi|56808185|ref|ZP_00365964.1|  COG1200: RecG-like helicase ...  1039   0.0  
 gi|50914858|ref|YP_060830.1|  ATP-dependent DNA helicase [St...  1039   0.0  
 gi|15675625|ref|NP_269799.1|  putative ATP-dependent DNA hel...  1039   0.0  
 gi|71904171|ref|YP_280974.1|  ATP-dependent DNA helicase [St...  1038   0.0  
 gi|21911087|ref|NP_665355.1|  putative ATP-dependent DNA hel...  1038   0.0


InterPro Summary:  InterProScan

InterPro
IPR001650
Domain
Helicase, C-terminal
PF00271 [491-567]T 2.3000044072653902E-21 PF00271 Helicase_C Helicase_C
SM00490 [486-567]T 1.5999999999999101E-22 SM00490 HELICc HELICc
PS51194 [445-605]T 0.0 PS51194 HELICASE_CTER HELICASE_CTER
InterPro
IPR004609
Family
ATP-dependent DNA helicase RecG
TIGR00643 [24-642]T 0.0 TIGR00643 recG recG
InterPro
IPR011545
Domain
DEAD/DEAH box helicase, N-terminal
PF00270 [254-416]T 3.1999989904635495E-30 PF00270 DEAD DEAD
InterPro
IPR014001
Domain
DEAD-like helicases, N-terminal
SM00487 [249-437]T 1.5000000000000598E-29 SM00487 DEXDc DEXDc
InterPro
IPR014021
Domain
Helicase superfamily 1 and 2 ATP-binding
PS51192 [267-426]T 0.0 PS51192 HELICASE_ATP_BIND_1 HELICASE_ATP_BIND_1
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [443-579]T 3.50000235434301E-15 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR10967 [253-579]T 5.29999657550191E-9 PTHR10967 PTHR10967 PTHR10967
SSF50249 [1-172]T 1.1E-39 SSF50249 Nucleic_acid_OB Nucleic_acid_OB


COGS Summary:  COGS Search
BeTs to 10 clades of COG1200
COG name: RecG-like helicases
Functional Class: L,K
The phylogenetic pattern of COG1200 is -----qvcebrhuj--ol--x
Number of proteins in this genome belonging to this COG is 2
Blocks Summary:  Blocks Search
No significant hits to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 223-565 are 21% similar to a (PROTEOME COMPETENCE COMPLETE ATP-BINDING) protein domain (PD132737 which is seen in CMF1_BACSU.

Residues 12-275 are 64% similar to a (DNA HELICASE ATP-BINDING ATP-DEPENDENT) protein domain (PD233697 which is seen in RECG_STRPN.

Residues 479-530 are 61% similar to a (HELICASE ATP-BINDING RNA RNA-BINDING ATP-DEPENDENT) protein domain (PD000033 which is seen in Q9CDH6_LACLA.

Residues 276-379 are 62% similar to a (HELICASE DNA ATP-BINDING COMPLETE PROTEOME DNA-BINDING) protein domain (PD003500 which is seen in RECG_STRPN.

Residues 352-409 are 35% similar to a (ATP-BINDING RECOMBINASE HELICASE DNA) protein domain (PD392202 which is seen in Q9ZVG0_ARATH.

Residues 531-640 are 89% similar to a (HELICASE DNA ATP-BINDING PROTEOME) protein domain (PD008437 which is seen in RECG_STRPN.

Residues 410-478 are 73% similar to a (HELICASE DNA ATP-BINDING ATP-DEPENDENT) protein domain (PD035483 which is seen in RECG_STRPN.

Residues 380-409 are 86% similar to a (HELICASE DNA ATP-BINDING COUPLING) protein domain (PD398886 which is seen in RECG_STRPN.


Paralogs:  Local Blast Search
SMu1669 is paralogously related (blast p-value < 1e-3) to SMu0006, a predicted transcription-repair coupling factor, to SMu0734, an excinuclease ABC (subunit B), to SMu0451, a late competence protein, to SMu0557, an ATP-dependent RNA helicase, and to SMu0434, a primosomal replication factor Y.


Pfam Summary:  Pfam Search
Residues 243 to 437 (E-value = 6.8e-26) place SMu1669 in the DEAD family which is described as DEAD/DEAH box helicase (PF00270)
Residues 491 to 567 (E-value = 4.2e-23) place SMu1669 in the Helicase_C family which is described as Helicase conserved C-terminal domain (PF00271)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
530  
546

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MDLQSSLAVLKGLGPKSAEKFHRLGIYTIEDLLLYYPFRYEDFKAKSVLD
LLDGEKAVVTGKVVTPANVQYYGFKRNRLSFKIKQDEAVIAVSFFNQPYL
QDKVELDQDIAIFGKWDQKKSALTGMKILAQVTDDMQPVYHVAQGISQSA
LIKAIQSAFEAGYLRFLSENLPQVLLNKYRLLDRQTATRAMHFPKDLEEY
KQALRRIKFEELFYFQLNLQVLKANNKSESNGLLITYDHDQVVAKIAALP
FALTNAQKRSLDEILADMKSGAHMNRLLQGDVGSGKTVIASLAMYAAYSA
GLQSALMVPTEILAEQHYESLRTLFPELSIALLTSGMKAAVRRSALAAIA
DGSVDMIVGTHALIQEGVDYHKLGLVITDEQHRFGVKQRRLFREKGENPD
VLMMTATPIPRTLAITAFGEMDVSLIDELPAGRKPIVTRWVKHEQLDKVL
PWVKEQLKKKEQVYVISPLIEESETLDLKNAVALEEDLKAYFASSANIAL
MHGRMKNDEKEAIMQAFKKGSIDILVSTTVIEVGVNVPNATIMIIMDADR
FGLSQLHQLRGRVGRGEKRSYAILVANPKTDTGKNRMRIMTKTTDGFVLA
EEDLKMRGSGEIFGVRQSGIPEFQVADIVEDYPILEEARKVASQIVAVKD
WCQDKRWAILVQNLKQKEILD

Gene Nucleotide Sequence:  Sequence Viewer
ATGGACTTACAGTCATCACTTGCGGTTTTAAAGGGATTAGGTCCTAAGTC
TGCAGAAAAATTTCATAGATTAGGCATTTATACCATTGAGGACTTGTTGC
TTTACTATCCTTTTCGTTATGAGGACTTTAAGGCAAAATCTGTTTTAGAT
TTGTTAGATGGTGAAAAAGCTGTTGTTACTGGAAAAGTAGTGACCCCAGC
TAATGTACAATATTATGGGTTTAAACGCAATCGTCTATCTTTTAAAATAA
AACAAGATGAAGCTGTTATTGCTGTTTCTTTTTTTAATCAGCCTTATTTA
CAAGATAAGGTGGAGCTTGATCAGGATATTGCTATTTTTGGAAAATGGGA
TCAAAAGAAGTCAGCTCTTACGGGCATGAAGATTTTGGCTCAAGTGACAG
ATGATATGCAGCCGGTTTATCATGTGGCACAAGGAATATCACAGTCAGCT
CTGATTAAGGCTATTCAATCCGCTTTTGAAGCTGGTTATTTACGCTTTTT
ATCTGAAAATTTACCGCAGGTTTTGCTTAATAAATATCGTTTGTTAGACA
GACAAACAGCTACGCGGGCTATGCATTTTCCGAAAGATTTGGAAGAATAT
AAACAAGCCTTGCGCCGCATCAAATTTGAGGAACTCTTTTATTTTCAACT
CAATTTGCAGGTTCTTAAAGCAAATAATAAATCAGAATCAAATGGTCTGC
TTATTACTTATGATCACGATCAAGTGGTTGCTAAAATAGCTGCTCTGCCT
TTTGCCTTGACGAATGCCCAAAAAAGGAGCTTAGACGAAATTCTGGCAGA
TATGAAGTCTGGCGCTCATATGAATCGGCTTTTACAGGGAGATGTCGGTT
CTGGTAAGACAGTCATTGCCAGTCTTGCTATGTATGCAGCCTATAGTGCA
GGTCTGCAGTCTGCTTTGATGGTTCCTACGGAAATTTTAGCGGAACAACA
TTATGAAAGTTTAAGGACTTTATTTCCTGAACTTTCAATTGCACTTTTGA
CGTCTGGGATGAAGGCTGCTGTAAGACGTTCAGCCTTAGCAGCTATCGCT
GATGGCTCAGTAGATATGATTGTTGGTACCCACGCTCTCATTCAAGAAGG
TGTTGATTACCATAAATTAGGCTTAGTTATTACGGATGAACAACATCGAT
TTGGTGTTAAGCAAAGGCGACTGTTTAGGGAAAAGGGAGAGAATCCTGAT
GTTCTCATGATGACAGCCACACCTATTCCTAGAACCTTGGCTATTACTGC
CTTTGGCGAAATGGATGTTTCTCTTATTGATGAATTGCCAGCAGGTCGCA
AACCGATTGTTACACGTTGGGTTAAGCATGAACAGTTAGATAAAGTTCTG
CCTTGGGTTAAAGAACAGCTCAAGAAAAAAGAACAAGTCTATGTCATTTC
ACCTTTGATTGAGGAGTCTGAAACCTTGGATTTGAAAAATGCTGTCGCTT
TAGAAGAAGACTTAAAAGCTTATTTTGCGTCGTCTGCTAATATTGCTCTT
ATGCATGGTCGTATGAAAAATGATGAAAAAGAAGCCATTATGCAGGCTTT
CAAAAAGGGCAGTATTGATATTCTGGTTTCAACAACTGTCATTGAAGTTG
GGGTCAATGTACCTAATGCTACGATTATGATTATTATGGATGCCGATCGT
TTTGGTCTTAGTCAATTGCATCAATTACGAGGACGTGTAGGACGTGGAGA
AAAGCGATCCTATGCCATTTTAGTTGCTAATCCTAAAACGGATACTGGGA
AAAATCGCATGCGCATTATGACAAAAACAACAGATGGCTTTGTTTTGGCT
GAAGAAGATTTAAAAATGCGTGGTTCAGGAGAAATTTTTGGTGTTCGTCA
ATCTGGCATTCCTGAATTTCAGGTGGCTGATATTGTGGAAGATTACCCTA
TTTTAGAAGAGGCTAGAAAAGTGGCTAGTCAAATTGTGGCCGTTAAAGAT
TGGTGTCAAGATAAACGATGGGCAATTCTTGTGCAAAATCTTAAGCAAAA
AGAAATTTTGGATTAA

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