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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR1411 IGR1407 IGR1408 IGR1404 IGR1403 IGR1401 IGR1410 IGR1400 IGR1402 IGR1412 IGR1405 SMu1642 SMu1632 SMu1633 SMu1638 SMu1635 SMu1640 SMu1641 nadD, - SMu1637 SMu1630 SMu1634 SMu1631 SMu1639 SMu1644 SMu1642 SMu1632 SMu1633 SMu1638 SMu1635 SMu1640 SMu1641 nadD, - SMu1637 SMu1630 SMu1634 SMu1631 SMu1639 SMu1644 SMu1632 SMu1641 nadD, - SMu1637 SMu1630 SMu1634 SMu1631 SMu1639 SMu1636 SMu1635 SMu1642 SMu1633 SMu1638 SMu1640 SMu1636 SMu1644 SMu1643 SMu1643


LANL Gene ID: SMu1637

GenBank Locus Tag: SMU.1799c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
nadD  

Definition:
nicotinate mononucleotide adenylyltransferase (nicotinate-nucleotide adenylyltransferase)

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
1701385

Gene Stop:
1700753

Gene Length:
633

Molecular Weight*:
24426

pI*:
6.70

Net Charge*:
-0.79

EC:
2.7.7.18  

Functional Class:
Biosynthesis of cofactors, prosthetic groups, and carriers; Pyridine nucleotides  

Gene Ontology:
Biological process
  GO:0009058    biosynthetic process
  GO:0009435    NAD biosynthetic process

Molecular function
  GO:0003824    catalytic activity
  GO:0016779    nucleotidyltransferase activity


Pathway: pathway table
Nicotinate and nicotinamide metabolism

Secondary Evidence:
Olland AM, Underwood KW, Czerwinski RM, Lo MC, Aulabaugh A, Bard J, Stahl ML, Somers WS, Sullivan FX, Chopra R.
Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
J Biol Chem. 2002 Feb 1;277(5):3698-707.
PMID: 11704676

Comment:
For other 'nad' genes see SMu0422 (nadE).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Similarities in gapped BLAST to conserved hypothetical proteins and adenylyltransferases. Residues 1-209 are 83% similar to gi15901579 from S.pneumoniae. Residues 22-210 are 59% similar to gi15673081, a predicted NadD protein, from L.lactis.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1662 (1e-104).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24380163|ref|NP_722118.1|  nicotinic acid mononucleotide ...   402   e-110
 gi|157075784|gb|ABV10467.1|  nicotinate (nicotinamide) nucle...   356   6e-97
 gi|25011746|ref|NP_736141.1|  nicotinic acid mononucleotide ...   353   4e-96
 gi|22537802|ref|NP_688653.1|  nicotinic acid mononucleotide ...   352   6e-96
 gi|77408253|ref|ZP_00784996.1|  nicotinate (nicotinamide) nu...   350   2e-95
 gi|125717438|ref|YP_001034571.1|  Nicotinate-nucleotide aden...   349   5e-95
 gi|148997803|ref|ZP_01825367.1|  nicotinate (nicotinamide) n...   348   8e-95
 gi|148994932|ref|ZP_01823934.1|  nicotinate (nicotinamide) n...   348   1e-94
 gi|15901579|ref|NP_346183.1|  nicotinic acid mononucleotide ...   346   6e-94
 gi|149011383|ref|ZP_01832630.1|  nicotinate (nicotinamide) n...   346   6e-94


InterPro Summary:  InterProScan

InterPro
IPR004820
Domain
Cytidylyltransferase
PF01467 [28-184]T 4.3000017064587905E-60 PF01467 CTP_transf_2 CTP_transf_2
InterPro
IPR004821
Domain
Cytidyltransferase-related
TIGR00125 [26-91]T 9.53514265624073E-9 TIGR00125 cyt_tran_rel cyt_tran_rel
InterPro
IPR005248
Family
Probable nicotinate-nucleotide adenylyltransferase
PTHR12039 [13-210]T 5.799996538547801E-44 PTHR12039 NAMN_adtrnsfrase NAMN_adtrnsfrase
TIGR00482 [28-209]T 3.88873221178071E-64 TIGR00482 NAMN_adtrnsfrase NAMN_adtrnsfrase
InterPro
IPR014729
Domain
Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620 [22-210]T 3.5999885290781606E-61 G3DSA:3.40.50.620 Rossmann-like_a/b/a_fold Rossmann-like_a/b/a_fold
noIPR
unintegrated
unintegrated
SSF52374 [22-210]T 1.1E-60 SSF52374 SSF52374 SSF52374


COGS Summary:  COGS Search
BeTs to 11 clades of COG1057
COG name: Predicted nucleotidyltransferases
Functional Class: R
The phylogenetic pattern of COG1057 is ----Yqvcebr-ujgpol---
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
No significant hits to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 28-155 are 65% similar to a (ADENYLYLTRANSFERASE DEAMIDO-NAD NICOTINATE-NUCLEOTIDE) protein domain (PD009578 which is seen in NADD_LACLA.

Residues 164-209 are 60% similar to a (ADENYLYLTRANSFERASE DEAMIDO-NAD) protein domain (PD405848 which is seen in Q9CIY1_LACLA.


Paralogs:  Local Blast Search
SMu1637 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
Residues 28 to 184 (E-value = 3.6e-62) place SMu1637 in the CTP_transf_2 family which is described as Cytidylyltransferase (PF01467)

 Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MALELLTPFTKVELEEERKDKNRKQIGILGGNFNPVHNAHLLVADQVRQQ
LGLDEVLLMPEYKPPHVDKKATIDEKHRLKMLELAIKGIEGLAIETIELK
RKGVSYTYDTMKDLIEQNPDVDYYFIIGADMVDYLPKWHKIDELIQMVQF
VGVQRPKYKAGTSYPVIWVDVPLMDISSSMIRDFIRKNRKPNFLLPKLVL
DYIEKEGLYQ

Gene Nucleotide Sequence:  Sequence Viewer
ATGGCTTTAGAACTGTTAACACCTTTTACTAAGGTGGAGTTGGAAGAAGA
AAGAAAAGATAAAAATCGAAAACAAATTGGTATCTTAGGCGGCAATTTTA
ATCCGGTTCACAATGCTCATCTGTTAGTAGCGGATCAAGTACGCCAGCAA
TTGGGCTTGGATGAGGTCTTGCTGATGCCAGAATACAAACCACCACACGT
TGATAAGAAGGCAACTATCGATGAAAAACATCGGCTCAAGATGCTGGAGT
TAGCTATTAAAGGTATTGAAGGCTTGGCTATTGAAACTATTGAGCTCAAA
CGTAAAGGAGTCTCTTATACCTACGACACCATGAAAGATTTGATTGAACA
AAATCCTGATGTTGATTATTATTTTATTATTGGTGCCGATATGGTAGACT
ATTTGCCTAAGTGGCACAAGATTGACGAGCTGATTCAGATGGTACAATTT
GTTGGCGTACAGCGTCCTAAATATAAGGCTGGAACTTCTTATCCTGTCAT
TTGGGTAGATGTACCGCTTATGGATATTTCCTCTAGTATGATTCGAGATT
TCATCCGTAAGAATAGAAAACCGAATTTTCTTTTACCAAAACTAGTTCTT
GACTATATTGAGAAAGAAGGACTTTATCAATGA

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