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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR1349 IGR1351 IGR1350 IGR1356 IGR1357 IGR1352 IGR1354 IGR1355 IGR1348 IGR1353 greA, - SMu1574 SMu1576 SMu1570 SMu1569 cspR, - SMu1571 lysA,tabA, - SMu1568 murC, - SMu1577 pabC, - SMu1575 snf, - SMu1579 SMu1572 SMu1573 greA, - SMu1574 SMu1576 SMu1570 SMu1569 cspR, - SMu1571 lysA,tabA, - SMu1568 murC, - SMu1577 pabC, - SMu1575 snf, - SMu1579 SMu1572 SMu1573 greA, - SMu1574 SMu1576 SMu1569 cspR, - SMu1571 lysA,tabA, - SMu1568 murC, - SMu1577 pabC, - SMu1575 SMu1578 snf, - SMu1579 SMu1570 SMu1578 SMu1572 SMu1573


LANL Gene ID: SMu1574

GenBank Locus Tag: SMU.1728c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
greA  

Definition:
transcription elongation factor GreA

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
1633307

Gene Stop:
1632825

Gene Length:
483

Molecular Weight*:
17570

pI*:
4.60

Net Charge*:
-7.98

EC:
 

Functional Class:
Transcription; Transcription factors  

Gene Ontology:
Biological process
  GO:0006355    regulation of transcription, DNA-dependent

Molecular function
  GO:0003677    DNA binding
  GO:0003711    transcriptional elongation regulator activity


Pathway: pathway table

Secondary Evidence:
Artsimovitch I, Svetlov V, Anthony L, Burgess RR, Landick R.
RNA polymerases from Bacillus subtilis and Escherichia coli differ in recognition of regulatory signals in vitro.
J Bacteriol. 2000 Nov;182(21):6027-35.
PMID: 11029421

Comment:


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Similarities in gapped BLAST to transcription elongation factor GreA sequences. Residues 1-159 are 77% similar to 15674504 from S.pyogenes and 72% similar to 15903412 from S.pneumoniae.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1612 (5e-65).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24380100|ref|NP_722055.1|  transcription elongation facto...   224   1e-57
 gi|116627175|ref|YP_819794.1|  Transcription elongation fact...   211   1e-53
 gi|55820339|ref|YP_138781.1|  transcription elongation facto...   211   1e-53
 gi|94993684|ref|YP_601782.1|  Transcription elongation facto...   206   3e-52
 gi|22537752|ref|NP_688603.1|  transcription elongation facto...   206   4e-52
 gi|15674504|ref|NP_268678.1|  transcription elongation facto...   205   8e-52
 gi|21909791|ref|NP_664059.1|  transcription elongation facto...   203   3e-51
 gi|146319370|ref|YP_001199082.1|  Transcription elongation f...   186   4e-46
 gi|157075602|gb|ABV10285.1|  transcription elongation factor...   185   6e-46
 gi|81177229|ref|ZP_00876085.1|  Prokaryotic transcription el...   184   1e-45


InterPro Summary:  InterProScan

InterPro
IPR001437
Domain
Transcription elongation factor, GreA/GreB region, prokaryotic
PD004918 [102-156]T 0.0 PD004918 GreA_GreB GreA_GreB
G3DSA:1.10.287.180 [3-77]T 3.39999972437687E-22 G3DSA:1.10.287.180 GreA_GreB_reg GreA_GreB_reg
PF01272 [82-158]T 2.49999811956444E-12 PF01272 GreA_GreB GreA_GreB
PF03449 [3-76]T 3.30000526807179E-21 PF03449 GreA_GreB_N GreA_GreB_N
PS00829 [19-50]T 8.0E-5 PS00829 GREAB_1 GREAB_1
PS00830 [122-138]T 8.0E-5 PS00830 GREAB_2 GREAB_2
SSF46557 [4-81]T 4.5E-26 SSF46557 GreA_GreB GreA_GreB
InterPro
IPR006359
Domain
Prokaryotic transcription elongation factor GreA
TIGR01462 [7-157]T 4.288624690221421E-75 TIGR01462 greA greA
InterPro
IPR012243
Family
Prokaryotic transcription elongation factor GreA, GreB
PIRSF006092 [3-159]T 8.300000000000501E-89 PIRSF006092 GreA GreA
noIPR
unintegrated
unintegrated
SSF54534 [81-159]T 3.6E-20 SSF54534 SSF54534 SSF54534


COGS Summary:  COGS Search
BeTs to 10 clades of COG0782
COG name: Transcription elongation factor
Functional Class: K
The phylogenetic pattern of COG0782 is ------v-EbRHujgpolinx
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB001437 (Prokaryotic transcription elongation factor GreA/GreB) with a combined E-value of 2.5e-45.
    IPB001437A    19-68
    IPB001437B    106-138


 ProDom Summary:  Protein Domain Search
Residues 67-157 are 34% similar to a (KINASE PROTEOME NUCLEOSIDE REGULATOR) protein domain (PD083674 which is seen in Q9RV68_DEIRA.

Residues 71-140 are 67% similar to a (FACTOR TRANSCRIPTION ELONGATION COIL) protein domain (PD344060 which is seen in GREA_LACLA.

Residues 26-65 are 87% similar to a (FACTOR TRANSCRIPTION ELONGATION COIL) protein domain (PD004918 which is seen in GREA_LACLA.


Paralogs:  Local Blast Search
SMu1574 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
Residues 3 to 76 (E-value = 3e-24) place SMu1574 in the GreA_GreB_N family which is described as Prokaryotic transcription elongation factor, GreA/GreB, N-terminal domain (PF03449)
Residues 82 to 158 (E-value = 2.2e-15) place SMu1574 in the GreA_GreB family which is described as Prokaryotic transcription elongation factor, GreA/GreB, C-terminal domain (PF01272)

 Top PDB Hits:
pdb|1GRJ| Grea Transcript Cleavage Factor From Escherichia Coli 118 5e-028

Gene Protein Sequence:
MSEKTYPMTLAEKEQLEQELEELKLVRRPEVIERIKIARSYGDLSENSEY
EAAKDEQAFVEGQISSIETKIRYAEIVDSDAVAKNEVAIGKTVIVREVGT
NDEDTYSIVGAAGADVFAGKISNESPIAQALIGKKTGDKVMIESPAGSYQ
VEIVKVKKTK

Gene Nucleotide Sequence:  Sequence Viewer
ATGTCAGAAAAAACTTATCCAATGACTCTTGCAGAAAAAGAACAATTAGA
ACAAGAACTTGAAGAGTTAAAATTAGTTCGTCGTCCAGAAGTGATTGAAC
GTATTAAAATAGCACGTTCTTATGGTGATTTATCAGAAAATAGTGAATAT
GAAGCGGCAAAAGATGAACAAGCTTTTGTTGAAGGACAAATTTCAAGTAT
TGAAACTAAAATTCGTTATGCTGAAATTGTTGACAGTGATGCTGTTGCTA
AAAATGAGGTCGCTATTGGTAAAACAGTTATTGTTCGTGAAGTAGGAACA
AACGATGAAGATACTTATTCTATTGTTGGTGCCGCCGGAGCTGATGTTTT
TGCTGGAAAAATTTCTAATGAGAGCCCAATTGCTCAAGCACTTATCGGTA
AGAAAACAGGTGATAAAGTAATGATTGAATCACCAGCGGGAAGTTATCAA
GTCGAAATTGTTAAAGTGAAAAAGACAAAATAA

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