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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR1283 IGR1281 IGR1282 IGR1287 IGR1284 IGR1280 IGR1276 IGR1285 IGR1278 IGR1286 IGR1279 IGR1277 SMu1491 SMu1490 SMu1486 rplK, - SMu1481 SMu1487 SMu1489 rplA, - SMu1480 mtnN, - SMu1485 glmU,gcaD, - SMu1488 sym,metS, - SMu1492 SMu1483 SMu1482 ppiA, - SMu1484 SMu1491 SMu1490 SMu1486 rplK, - SMu1481 SMu1487 SMu1489 rplA, - SMu1480 mtnN, - SMu1485 glmU,gcaD, - SMu1488 sym,metS, - SMu1492 SMu1483 SMu1482 ppiA, - SMu1484 SMu1491 SMu1487 SMu1489 rplA, - SMu1480 mtnN, - SMu1485 glmU,gcaD, - SMu1488 sym,metS, - SMu1492 SMu1483 SMu1490 SMu1486 rplK, - SMu1481 SMu1482 ppiA, - SMu1484


LANL Gene ID: SMu1485

GenBank Locus Tag: SMU.1632c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
mtnN  

Definition:
MTA/SAH nucleosidase

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
1558065

Gene Stop:
1557370

Gene Length:
696

Molecular Weight*:
25203

pI*:
6.10

Net Charge*:
-4.87

EC:
3.2.2.16  3.2.2.9  

Functional Class:
Purines, pyrimidines, nucleosides, and nucleotides; Salvage of nucleosides and nucleotides  

Gene Ontology:
Biological process
  GO:0009116    nucleoside metabolic process
  GO:0009164    nucleoside catabolic process
  GO:0019509    methionine salvage

Molecular function
  GO:0003824    catalytic activity
  GO:0008782    adenosylhomocysteine nucleosidase activity
  GO:0008930    methylthioadenosine nucleosidase activity


Pathway: pathway table
Arginine and proline metabolism
Methionine metabolism

Secondary Evidence:
Cornell,K.A. and Riscoe,M.K.
Cloning and expression of Escherichia coli
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase:
identification of the pfs gene product
Biochim. Biophys. Acta 1396 (1), 8-14 (1998)
PubMed: 9524204


Comment:


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Several matches in gapped BLAST to MTA/SAH nucleosidase: residues 1-229 are 54% similar to the enzyme in S.pyogenes (gi15674570). Residues 1-230 are 53% similar to the protein from S.pneumoniae (gi15902938).





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1535 (5e-76).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24380011|ref|NP_721966.1|  5'-methylthioadenosine/S-adeno...   388   e-106
 gi|55820645|ref|YP_139087.1|  5'-methylthioadenosine/S-adeno...   299   7e-80
 gi|77411374|ref|ZP_00787721.1|  MTA/SAH nucleosidase [Strept...   284   4e-75
 gi|25011632|ref|NP_736027.1|  5'-methylthioadenosine/S-adeno...   283   6e-75
 gi|22537678|ref|NP_688529.1|  5'-methylthioadenosine/S-adeno...   282   1e-74
 gi|157074579|gb|ABV09262.1|  MTA/SAH nucleosidase [Streptoco...   266   6e-70
 gi|15902938|ref|NP_358488.1|  5'-methylthioadenosine/S-adeno...   265   2e-69
 gi|81176818|ref|ZP_00875802.1|  Adenosylhomocysteine nucleos...   264   4e-69
 gi|125718443|ref|YP_001035576.1|  5'-methylthioadenosine/S-a...   263   4e-69
 gi|146319235|ref|YP_001198947.1|  Nucleoside phosphorylase [...   259   6e-68


InterPro Summary:  InterProScan

InterPro
IPR000845
Family
Nucleoside phosphorylase
PF01048 [2-226]T 8.10000734323342E-58 PF01048 PNP_UDP_1 PNP_UDP_1
InterPro
IPR010049
Family
MTA/SAH nucleosidase
TIGR01704 [2-229]T 3.9220027630867504E-60 TIGR01704 MTA/SAH-Nsdase MTA/SAH-Nsdase
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.1580 [1-229]T 1.9000069431527E-71 G3DSA:3.40.50.1580 G3DSA:3.40.50.1580 G3DSA:3.40.50.1580
PTHR21234 [1-231]T 3.4999946686394907E-57 PTHR21234 PTHR21234 PTHR21234
PTHR21234:SF6 [1-231]T 3.4999946686394907E-57 PTHR21234:SF6 PTHR21234:SF6 PTHR21234:SF6
SSF53167 [1-230]T 1.1E-72 SSF53167 SSF53167 SSF53167


COGS Summary:  COGS Search
BeTs to 9 clades of COG0775
COG name: Nucleoside phosphorylase
Functional Class: F
The phylogenetic pattern of COG0775 is ------vcEbRhuj--OliN-
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB000845 (Purine and other phosphorylases, family 1) with a combined E-value of 3.1e-07.
    IPB000845B    29-63
    IPB000845C    142-152
    IPB000845D    167-203


 ProDom Summary:  Protein Domain Search
Residues 33-112 are 70% similar to a (PHOSPHORYLASE NUCLEOSIDASE COMPLETE PROTEOME) protein domain (PD003928 which is seen in Q9CEG1_LACLA.

Residues 161-211 are 52% similar to a (NUCLEOSIDASE HYDROLASE ENZYME) protein domain (PD005987 which is seen in Q9CEG1_LACLA.


Paralogs:  Local Blast Search
SMu1485 is paralogously related (blast p-value < 1e-3) to SMu1122, a predicted purine-nucleotide phosphorylase.


Pfam Summary:  Pfam Search
Residues 2 to 226 (E-value = 7.2e-61) place SMu1485 in the PNP_UDP_1 family which is described as Phosphorylase family (PF01048)

 Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MKIGIIAAMEEELKLLLAELNHKREEICLERPYYSGKLGKHQVVLVQSGV
GKVMSAMSVAVLVDHFKVDALINTGSAGALAPDLAIGDVVVADRLAYHDV
DLTALGYEFGRMSGQPLFFKSDQTFVSAFEEVLAKHHIHSKIGLITTSDS
FMAGKEKTIFVKEHFPEVQAVEMEGAAIAQAAYAAKRPFVVIRSISDTAA
HDANITFEEFVVKAGKQSAQVLLKFLEILDQ

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAAATTGGAATTATTGCAGCTATGGAGGAAGAATTAAAACTCCTCTT
AGCGGAATTAAATCATAAAAGAGAAGAAATCTGTTTAGAACGACCTTACT
ACAGCGGTAAACTAGGTAAACATCAGGTCGTTCTGGTGCAAAGCGGTGTT
GGCAAAGTCATGTCTGCTATGAGTGTGGCTGTTTTAGTAGATCATTTTAA
AGTTGATGCTTTGATTAATACAGGTTCAGCAGGAGCTTTAGCGCCAGATT
TGGCTATTGGTGATGTTGTAGTGGCAGATAGACTCGCTTATCATGATGTA
GATTTAACTGCCCTTGGTTATGAATTTGGACGTATGTCAGGGCAGCCTCT
TTTCTTTAAATCAGACCAAACCTTTGTGAGCGCTTTTGAAGAGGTGTTGG
CTAAGCACCATATTCATAGTAAAATCGGTCTCATTACAACCAGTGATTCC
TTTATGGCTGGTAAGGAAAAAACGATTTTTGTTAAGGAACATTTTCCAGA
AGTGCAGGCAGTTGAGATGGAAGGCGCAGCGATTGCTCAAGCAGCTTATG
CAGCCAAACGCCCTTTTGTCGTTATTCGATCAATCAGTGATACAGCAGCT
CATGATGCCAATATTACTTTTGAAGAATTTGTTGTTAAGGCTGGAAAACA
ATCGGCTCAAGTCCTCTTAAAATTTTTGGAAATCTTAGACCAATGA

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