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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR1202 IGR1204 IGR1201 IGR1200 IGR1205 IGR1207 IGR1206 uncE,atpE, - SMu1395 uncF,atpF, - SMu1393 atpH,uncH, - SMu1392 atpB, - SMu1394 atpG, - SMu1390 atpD, - SMu1389 glgA, - SMu1397 atpA, - SMu1391 glgP, - SMu1396 uncE,atpE, - SMu1395 uncF,atpF, - SMu1393 atpH,uncH, - SMu1392 atpB, - SMu1394 atpG, - SMu1390 atpD, - SMu1389 glgA, - SMu1397 atpA, - SMu1391 glgP, - SMu1396 uncE,atpE, - SMu1395 uncF,atpF, - SMu1393 atpH,uncH, - SMu1392 atpB, - SMu1394 atpG, - SMu1390 atpD, - SMu1389 glgA, - SMu1397 atpA, - SMu1391 glgP, - SMu1396 glgD, - SMu1398 glgD, - SMu1398


LANL Gene ID: SMu1395

GenBank Locus Tag: SMU.1534c

DNA Molecule Name:
1  

GenBank ID:


Gene Name:
uncE  atpE  

Definition:
ATPase, c subunit

Cellular Location:
Membrane, Extracellular [Evidence]

Gene Start:
1459547

Gene Stop:
1459344

Gene Length:
204

Molecular Weight*:
7042

pI*:
9.40

Net Charge*:
0.98

EC:
3.6.1.-  

Functional Class:
Energy metabolism; ATP-proton motive force interconversion  

Gene Ontology:
Biological process
  GO:0015986    ATP synthesis coupled proton transport

Cellular component
  GO:0016020    membrane
  GO:0016469    proton-transporting two-sector ATPase complex

Molecular function
  GO:0046933    hydrogen ion transporting ATP synthase activity, rotational mechanism
  GO:0046961    hydrogen ion transporting ATPase activity, rotational mechanism


Pathway: pathway table
Folate biosynthesis
Starch and sucrose metabolism

Primary Evidence:
Smith,A.J., Quivey,R.G. Jr. and Faustoferri,R.C.
Cloning and nucleotide sequence analysis of the Streptococcus
mutans membrane-bound, proton-translocating ATPase operon
Gene 183 (1-2), 87-96 (1996)
PubMed: 8996091


Comment:
For other 'unc' genes see SMu1388 (uncC); SMu1390 (uncG); SMu1392 (uncH); SMu1393 (uncF) and SMu1394 (uncB).

See SMu1388 for proton-translocating ATPase, epsilon subunit.
See SMu1389 for ATPase, beta subunit.
See SMu1390 for ATPase, gamma subunit.
See SMu1391 for ATP synthase alpha chain.
See SMu1392 for ATPase, delta subunit.
See SMu1393 for ATPase, b subunit.
See SMu1394 for ATPase, a subunit.



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to ATP synthase beta subunit:residues 1-67 are 100% similar to the previously published enzyme in S.mutans (2493075|),(7436175|) and (1773260|)

Residues 1-67 are 92% similar to ATP synthase c subunit in S.bovis (2662320|).





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0857 (8e-25).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379923|ref|NP_721878.1|  FoF1 membrane-bound proton-tra...    93   4e-18
 gi|2662320|dbj|BAA23749.1|  proton-translocating ATPase, c s...    87   2e-16
 gi|22537020|ref|NP_687871.1|  ATP synthase F0, C subunit [St...    77   2e-13
 gi|55822451|ref|YP_140892.1|  proton-translocating ATPase, c...    74   3e-12
 gi|55820561|ref|YP_139003.1|  proton-translocating ATPase, c...    73   5e-12
 gi|157076460|gb|ABV11143.1|  ATP synthase F0  C subunit [Str...    64   3e-09
 gi|125717630|ref|YP_001034763.1|  Proton-translocating ATPas...    62   1e-08
 gi|15004326|gb|AAK77031.1|AF334391_1  H+-transporting ATP sy...    59   6e-08
 gi|149393070|gb|ABR26597.1|  FOF1 ATPase c subunit [Streptoc...    59   8e-08
 gi|15674802|ref|NP_268976.1|  H+-transporting ATP synthase c...    59   8e-08


InterPro Summary:  InterProScan

InterPro
IPR000454
Family
ATPase, F0 complex, subunit C
PR00124 [4-23]T 1.4E-7 PR00124 ATPASEC[25-40]T 1.4E-7 PR00124 ATPASEC[42-67]T 1.4E-7 PR00124 ATPASEC ATPASEC
PS00605 [32-53]T 8.0E-5 PS00605 ATPASE_C ATPASE_C
InterPro
IPR002379
Family
ATPase, F0/V0 complex, subunit C
G3DSA:1.20.20.10 [7-65]T 1.1999998570310098E-6 G3DSA:1.20.20.10 ATPase_F0/V0_c ATPase_F0/V0_c
PF00137 [7-55]T 1.0E-6 PF00137 ATP-synt_C ATP-synt_C
SSF81333 [7-66]T 9.6E-10 SSF81333 ATPase_F0/V0_c ATPase_F0/V0_c


COGS Summary:  COGS Search
BeTs to 11 clades of COG0636
COG name: FoF1-type ATP synthase c subunit/Vacuolar ATPase/archaeal ATP synthase K subunit
Functional Class: C
The phylogenetic pattern of COG0636 is AmtkYqvcebrhujgpolinx
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB000454 (Eubacterial and plasma membrane ATP synthase subunit C) with a combined E-value of 1.5e-20.
    IPB000454    8-61


 ProDom Summary:  Protein Domain Search
Residues 2-66 are identical to a (LIPID-BINDING C ION TRANSMEMBRANE) protein domain (PD399852 which is seen in ATPL_STRMU.


Paralogs:  Local Blast Search
SMu1395 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
Residues 4 to 61 (E-value = 4.7e-05) place SMu1395 in the ATP-synt_C family which is described as ATP synthase subunit C (PF00137)

 Structural Feature(s):
Feature Type  Start  Stop
cleavable  
1  
30
transmembrane  
44  
60

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MLNLKILALGIAVLGVSLGEGILVANIAKSAARQPEMYGKLQTLMIMGVA
FIEGTFFVLLASTFFVG

Gene Nucleotide Sequence:  Sequence Viewer
ATGTTGAATTTAAAGATTTTAGCACTTGGGATTGCTGTTTTAGGCGTTAG
CCTTGGTGAAGGAATTTTAGTTGCTAATATTGCAAAATCTGCAGCTCGTC
AGCCTGAAATGTATGGTAAATTACAAACGCTCATGATTATGGGTGTTGCC
TTTATTGAAGGTACCTTTTTCGTGCTTCTTGCTTCAACATTCTTTGTTGG
CTGA

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