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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR965 IGR970 IGR971 IGR975 IGR967 IGR973 IGR972 IGR976 IGR969 IGR966 SMu1126 SMu1127 SMu1125 rpiA, - SMu1129 deoD, - SMu1122 gat, - SMu1123 SMu1121 pyrDII,pyrZ, - SMu1119 punA,pnp, - SMu1124 pyrD, - SMu1118 deoB,ppm, - SMu1128 cpsY, - SMu1120 thdF, - SMu1130 SMu1126 SMu1127 SMu1125 rpiA, - SMu1129 deoD, - SMu1122 gat, - SMu1123 SMu1121 pyrDII,pyrZ, - SMu1119 punA,pnp, - SMu1124 pyrD, - SMu1118 deoB,ppm, - SMu1128 cpsY, - SMu1120 thdF, - SMu1130 Type: tandem, Name: SMu-TR-19 - 19 SMu1125 rpiA, - SMu1129 deoD, - SMu1122 gat, - SMu1123 SMu1121 pyrDII,pyrZ, - SMu1119 punA,pnp, - SMu1124 pyrD, - SMu1118 deoB,ppm, - SMu1128 pyrF, - SMu1117 pyrF, - SMu1117 SMu1127 SMu1126 cpsY, - SMu1120 thdF, - SMu1130


LANL Gene ID: SMu1123

GenBank Locus Tag: SMU.1228c

DNA Molecule Name:
1  

GenBank ID:
24379652

Gene Name:
gat  

Definition:
glutamine amidotransferase

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
1169612

Gene Stop:
1168902

Gene Length:
711

Molecular Weight*:
26579

pI*:
4.90

Net Charge*:
-9.45

EC:
4.1.3.27  

Functional Class:
Amino acid biosynthesis; Aromatic amino acid family  
Signal transduction; Two-component systems  

Gene Ontology:
Molecular function
  GO:0003824    catalytic activity


Pathway: pathway table
Phenylalanine, tyrosine and tryptophan biosynthesis
Two-component system - General

Comment:
For other 'gat' genes see SMu1657 (gatB); SMu1658 (gatA); SMu1659 (gatC) and SMu1660 (gatA).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to conserved hypotheticals: residues 1-155 are 52% similar to gi507928 Orf170 [Salmonella typhimurium]. Residues 1-191 are 36% similar to D64006, hypothetical protein [Synechocystis sp.].





SMu1123 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379652|ref|NP_721607.1|  glutamine amidotransferase [St...   474   e-132
 gi|157075082|gb|ABV09765.1|  glutamine amidotransferase, cla...   281   2e-74
 gi|55823041|ref|YP_141482.1|  glutamine amidotransferase [St...   266   1e-69
 gi|16761356|ref|NP_456973.1|  glutamine amidotransferase [Sa...   263   5e-69
 gi|157081855|gb|ABV11533.1|  hypothetical protein CKO_00370 ...   262   1e-68
 gi|16765757|ref|NP_461372.1|  glutamine amidotransferase [Sa...   259   1e-67
 gi|62181005|ref|YP_217422.1|  glutamine amidotransferase [Sa...   258   1e-67
 gi|152970333|ref|YP_001335442.1|  putative glutamine amidotr...   249   8e-65
 gi|146284540|ref|YP_001165493.1|  glutamine amidotransferase...   247   4e-64
 gi|56552751|ref|YP_163590.1|  glutamine amidotransferase [Zy...   232   1e-59


InterPro Summary:  InterProScan

InterPro
IPR000991
Domain
Glutamine amidotransferase class-I
PF00117 [12-197]T 4.2000000191072897E-4 PF00117 GATase GATase
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.880 [1-231]T 4.7999872279810404E-51 G3DSA:3.40.50.880 G3DSA:3.40.50.880 G3DSA:3.40.50.880
SSF52317 [1-235]T 7.4E-39 SSF52317 SSF52317 SSF52317


COGS Summary:  COGS Search
BeTs to 9 clades of COG0518
COG name: GMP synthase - Glutamine amidotransferase domain
Functional Class: F
The phylogenetic pattern of COG0518 is AmtkYqVCebrHuj--o--n-
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
No significant hits to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 140-234 are 57% similar to a (DOMAIN OF UNKNO N) protein domain (PD279105 which is seen in Q9EUP8_STRTR.

Residues 1-124 are 60% similar to a (TRANSFERASE GLUTAMINE PROTEOME COMPLETE) protein domain (PD349562 which is seen in Q9EUP9_STRTR.

Residues 139-191 are 43% similar to a (PROTEOME COMPLETE TRANSFERASE GMP) protein domain (PD095787 which is seen in Q55488_SYNY3.


Paralogs:  Local Blast Search
SMu1123 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
Residues 12 to 197 (E-value = 1.1e-05) place SMu1123 in the GATase family which is described as Glutamine amidotransferase class-I (PF00117)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
86  
102

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MRIHFILHETFEAPGAYLAWAALRGHDVSMTKVYRYEKLPKDIDDFDMLI
LMGGPQSPSSTKKEFPYYDAQAEVKLIQKAAKSEKIIVGVCLGAQLMGVA
YGADYLHSPKKEIGNYLISLTEAGKMDSYLSDFSDDLLVGHWHGDMPGLP
DKAQVLAISQGCPRQIIKFGPKQYAFQCHLEFTPELVAALIAQEDDLDTQ
SQTETYVQTAEEMQTFDYSSMNQALYSFLDRLTERK

Gene Nucleotide Sequence:  Sequence Viewer
ATGAGAATTCATTTTATCCTTCACGAAACATTTGAGGCACCCGGTGCCTA
CTTAGCTTGGGCAGCTCTTCGTGGTCACGACGTATCTATGACTAAGGTTT
ATCGTTATGAAAAGCTTCCTAAAGACATTGATGACTTTGATATGTTAATT
CTTATGGGAGGACCTCAAAGTCCTTCCAGTACGAAAAAAGAATTTCCTTA
TTACGACGCCCAAGCAGAAGTTAAATTAATTCAAAAGGCTGCTAAGTCTG
AGAAAATCATTGTTGGCGTCTGTCTGGGTGCTCAATTGATGGGAGTAGCT
TATGGTGCAGATTATTTGCATAGTCCTAAAAAAGAAATTGGCAATTACTT
GATTTCTTTGACAGAAGCTGGGAAAATGGATTCTTATTTAAGCGATTTTT
CAGATGACTTGCTTGTTGGTCATTGGCATGGAGATATGCCTGGTTTGCCA
GATAAGGCTCAAGTTTTGGCCATCAGTCAGGGCTGTCCTAGACAAATTAT
TAAATTTGGTCCTAAGCAATACGCTTTTCAATGTCATTTGGAATTTACAC
CTGAATTGGTCGCTGCCTTAATTGCGCAAGAAGATGATTTGGATACTCAA
AGTCAAACAGAAACTTATGTACAGACAGCTGAGGAAATGCAGACCTTTGA
TTACTCGTCAATGAATCAAGCCTTGTATTCATTTTTGGATCGACTGACAG
AAAGAAAATAA

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