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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR928 IGR931 IGR927 IGR933 IGR930 IGR929 IGR934 phnA, - SMu1081 mtlA2, - SMu1083 msmK, - SMu1079 glnP, - SMu1080 atmA,abp,aatB, - SMu1078 mtlD, - SMu1082 mtlA, - SMu1085 glmS, - SMu1086 mtlR, - SMu1084 phnA, - SMu1081 mtlA2, - SMu1083 msmK, - SMu1079 glnP, - SMu1080 atmA,abp,aatB, - SMu1078 mtlD, - SMu1082 mtlA, - SMu1085 glmS, - SMu1086 mtlR, - SMu1084 phnA, - SMu1081 mtlA2, - SMu1083 msmK, - SMu1079 glnP, - SMu1080 atmA,abp,aatB, - SMu1078 mtlD, - SMu1082 mtlA, - SMu1085 glmS, - SMu1086 mtlR, - SMu1084


LANL Gene ID: SMu1084

GenBank Locus Tag: SMU.1184c

DNA Molecule Name:
1  

GenBank ID:
24379613

Gene Name:
mtlR  

Definition:
transcriptional regulator

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
1125321

Gene Stop:
1123369

Gene Length:
1953

Molecular Weight*:
75330

pI*:
6.70

Net Charge*:
-1.95

EC:
 

Functional Class:
Regulatory functions; General regulatory  

Gene Ontology:
Biological process
  GO:0006810    transport
  GO:0009401    phosphoenolpyruvate-dependent sugar phosphotransferase system

Molecular function
  GO:0005351    sugar porter activity


Pathway: pathway table

Primary Evidence:
Honeyman,A.L. and Curtiss,R. III.
Isolation, characterization, and nucleotide sequence of the
Streptococcus mutans mannitol-phosphate dehydrogenase gene and the
mannitol-specific factor III gene of the phosphoenolpyruvate
phosphotransferase system
Infect. Immun. 60 (8), 3369-3375 (1992)
PubMed: 1322373


Comment:
For other 'mtl' genes see SMu1083 (mtlA2);SMu1082 (mtlD) and SMu1085 (mtlA).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to transcriptional regulator:residues 1-650 are 98% similar to the previously published enzyme in S.mutans (9622945|).

Residues 1-649 are 53% similar to transcriptional regulator in S.pneumoniae (15900315|).Residues 1-646 are 29% similar to the protein from Lactococcus lactis subsp. lactis (15672004|).





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1801 (5e-09).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379613|ref|NP_721568.1|  putative transcriptional regul...  1167   0.0  
 gi|9622945|gb|AAA26940.2|  putative transcriptional regulato...  1149   0.0  
 gi|15900315|ref|NP_344919.1|  transcriptional regulator, put...   629   e-178
 gi|15902401|ref|NP_357951.1|  hypothetical protein spr0357 [...   627   e-178
 gi|149023683|ref|ZP_01836163.1|  transcriptional regulator, ...   627   e-178
 gi|149008015|ref|ZP_01831572.1|  transcriptional regulator, ...   626   e-177
 gi|149012146|ref|ZP_01833255.1|  transcriptional regulator, ...   479   e-133
 gi|15672004|ref|NP_266178.1|  LysR family transcription regu...   245   8e-63
 gi|116510863|ref|YP_808079.1|  Transcriptional antiterminato...   229   7e-58
 gi|125622904|ref|YP_001031387.1|  transcriptional regulator ...   228   8e-58


InterPro Summary:  InterProScan

InterPro
IPR002178
Domain
Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2
PS51094 [490-640]T 0.0 PS51094 PTS_EIIA_TYPE_2 PTS_EIIA_TYPE_2
InterPro
IPR013196
Domain
Helix-turn-helix, type 11
PF08279 [6-62]T 0.559999989417023 PF08279 HTH_11[84-140]T 3.50000043291567E-4 PF08279 HTH_11 HTH_11
noIPR
unintegrated
unintegrated
SSF46785 [1-66]T 5.4E-7 SSF46785 SSF46785[77-144]T 1.4E-7 SSF46785 SSF46785 SSF46785
SSF55804 [492-641]T 2.2E-9 SSF55804 SSF55804 SSF55804
SSF63520 [251-380]T 0.0046 SSF63520 SSF63520 SSF63520


COGS Summary:  COGS Search
No hits to the COGs database.
Blocks Summary:  Blocks Search
No significant hits to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 1-330 are 31% similar to a (PROTEOME TRANSCRIPTIONAL LYSR COMPLETE) protein domain (PD401622 which is seen in Q9CJH3_LACLA.

Residues 3-314 are 21% similar to a (REGULATOR DEOR) protein domain (PD321515 which is seen in Q9F8B7_STRAG.

Residues 496-640 are 33% similar to a (TRANSCRIPTIONAL PROTEOME REGULATOR) protein domain (PD357610 which is seen in Q9CJH3_LACLA.

Residues 79-165 are 34% similar to a (TRANSCRIPTIONAL PROTEOME COMPLETE) protein domain (PD338858 which is seen in P96574_BACSU.


Paralogs:  Local Blast Search
SMu1084 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
No significant hits to the Pfam 11.0 database

 Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MLLTKREKHLLAAFQNYGKLSLKQMIDLLKVSQRTVYRTISDLTDSLNTI
NISIIKENQNYFLVGELANLASIISLDTYEQYERLNLITYKLLMSFSSIT
NEQLQEEFNVSNVTIIQDIAEIEKRLADFDLRLDRKKGYRLVGNKNTLRR
LLAILLTNNLSISDFGAGAYGHFEVLDKAKLELAKQIFQSSQEDLPDLDA
KMSEFFIILLALSGWRDNEAVGHSISKAALDFSQKVYTEFSQKTNQFYSI
QEILYYASILDELVIKRQETPLFHEKFDSAFFYNISNLIDKVSLYTKINF
AKDKTLFHFLFNHIRLNLAVPQIFEDKSNNTIAHEVVQGNEYLHRVVSLL
VQDIFPKYLQKEPEYELITLHFASSLRRSPDIYPIKILLLTDERPLAREL
LITRIKTIAPFVDKVVVKELAQYETKDKDYYNCVLATKPLVDKAVKMVST
YPDAKEMLQLQDYLQNVQAHQKIIIRDEQTNKQGYNLQNYFLATQQLLQE
FSYQEIDNPADFETSVPKIMETIAAVSDKTYLSSKLLKCFAVSPLAIPET
HLALLHTQSSKVITSCFKIYDLKRPVTALSMNYEKETVTRILVMLTRLDE
TKEMRDLMTAISQSIIENHLYTEIYKTGNKDIIYQLLNQIFTEKIKKLET


Gene Nucleotide Sequence:  Sequence Viewer
ATGCTATTAACAAAGAGAGAAAAACACTTATTAGCAGCTTTCCAAAATTA
TGGGAAGCTGTCGCTTAAACAGATGATAGATTTGCTTAAGGTATCTCAGA
GAACCGTTTATCGGACAATTTCTGATTTAACAGATAGCCTTAACACGATT
AATATTAGCATCATCAAAGAAAATCAAAACTATTTTCTCGTAGGAGAATT
AGCTAATCTGGCTAGTATTATTAGTCTAGATACTTATGAACAGTATGAAC
GTTTGAATCTCATTACCTATAAGTTATTGATGAGTTTTAGCAGTATCACA
AATGAGCAGCTGCAGGAGGAATTTAATGTTTCTAATGTTACCATTATTCA
AGATATTGCTGAAATTGAAAAGCGTTTGGCAGATTTTGACTTACGGTTAG
ATCGTAAAAAAGGTTACCGTTTAGTAGGAAATAAAAACACTTTACGACGT
TTATTGGCTATTTTATTAACTAATAACCTTTCGATTTCTGATTTTGGGGC
AGGAGCATATGGTCATTTTGAAGTCTTAGACAAGGCAAAATTAGAACTTG
CGAAACAAATCTTTCAATCATCACAAGAAGATCTACCTGATTTAGATGCT
AAGATGAGTGAGTTTTTCATCATTCTCTTAGCCTTATCAGGTTGGCGGGA
CAATGAAGCAGTTGGACACAGTATTAGCAAAGCAGCTCTTGATTTTTCAC
AGAAAGTTTATACTGAATTTTCACAGAAAACCAATCAATTTTACAGTATT
CAAGAGATTCTTTATTATGCCAGTATTTTAGATGAACTGGTTATTAAGAG
ACAGGAAACGCCGCTTTTTCATGAAAAATTTGACAGTGCTTTTTTCTATA
ATATTTCAAATTTGATTGATAAAGTATCTCTTTATACTAAAATTAATTTT
GCTAAGGATAAAACACTCTTTCATTTTCTGTTTAATCATATTCGCTTGAA
TTTGGCTGTCCCTCAAATTTTTGAAGACAAGTCAAATAATACGATTGCTC
ATGAGGTTGTTCAAGGCAATGAATATCTACATCGTGTTGTTAGTCTTCTG
GTTCAGGATATTTTTCCGAAGTATTTGCAAAAGGAACCAGAGTATGAATT
AATTACCTTACATTTTGCTTCAAGTCTGCGCCGCAGTCCAGATATTTATC
CTATTAAGATTTTACTTTTAACAGATGAGCGTCCCTTAGCGAGAGAACTT
CTCATCACACGTATTAAAACCATTGCACCTTTTGTTGATAAGGTAGTTGT
CAAAGAATTGGCTCAGTATGAAACAAAGGATAAAGATTATTATAATTGTG
TCTTGGCAACCAAGCCTTTAGTGGATAAGGCAGTCAAAATGGTTTCTACT
TATCCTGATGCAAAAGAAATGCTGCAACTTCAAGATTATTTACAGAATGT
ACAGGCTCATCAAAAAATCATCATTCGCGATGAGCAGACAAATAAGCAAG
GTTATAATCTTCAAAATTATTTTTTGGCTACACAACAACTTTTACAGGAA
TTTTCTTATCAAGAGATTGATAATCCTGCTGATTTTGAAACAAGTGTTCC
AAAAATTATGGAGACTATTGCTGCAGTTTCAGATAAAACTTATCTGTCCA
GTAAGTTATTAAAATGTTTTGCTGTCAGTCCCTTGGCTATTCCAGAGACT
CATTTGGCTCTTTTGCATACACAGTCAAGTAAGGTTATAACGTCTTGTTT
TAAAATTTATGATTTAAAAAGACCTGTAACAGCTCTGTCCATGAATTACG
AAAAAGAGACAGTTACAAGAATTTTGGTTATGCTGACACGGTTAGATGAA
ACAAAAGAAATGAGAGATTTAATGACGGCCATCAGTCAATCTATCATCGA
AAATCATCTTTATACAGAAATTTACAAGACAGGTAATAAAGATATTATTT
ATCAATTATTGAATCAAATATTTACAGAAAAAATAAAGAAATTGGAGACC
TAA

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