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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR727 IGR724 IGR723 IGR722 IGR729 IGR728 IGR730 IGR726 SMu0830 SMu0831 SMu0834 SMu0832 SMu0835 SMu0839 tpx, - SMu0838 SMu0840 llrF, - SMu0841 gdhA, - SMu0829 SMu0836 SMu0830 SMu0831 SMu0834 SMu0832 SMu0835 SMu0839 tpx, - SMu0838 SMu0840 llrF, - SMu0841 gdhA, - SMu0829 SMu0836 SMu0830 SMu0832 ygcM,ykvK, - SMu0833 ygcM,ykvK, - SMu0833 SMu0834 SMu0831 SMu0835 SMu0839 tpx, - SMu0838 llrF, - SMu0841 gdhA, - SMu0829 SMu0836 SMu0837 SMu0837 SMu0840


LANL Gene ID: SMu0836

GenBank Locus Tag: SMU.922

DNA Molecule Name:
1  

GenBank ID:
24379367

Gene Name:


Definition:
ABC-type multidrug / protein/ lipid transport system, ATPase component

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
875028

Gene Stop:
876830

Gene Length:
1803

Molecular Weight*:
66961

pI*:
10.00

Net Charge*:
10.44

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: membrane spanning permease  

Gene Ontology:
Biological process
  GO:0006810    transport

Cellular component
  GO:0016021    integral to membrane

Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity
  GO:0042626    ATPase activity, coupled to transmembrane movement of substances


Pathway: pathway table

Primary Evidence:
Qi,F., Chen,P. and Caufield,P.W.
Purification of mutacin III from group III streptococcus mutans
UA787 and genetic analyses of mutacin III biosynthesis genes
Appl. Environ. Microbiol. 65 (9), 3880-3887 (1999)
PubMed: 10473390
Pubmed: 10473390


Comment:
For other components see SMu0836 (NBD1); SMu0837 (NBD2) and SMu0837 (MSD2).

View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Several matches in gapped BLAST to ABC-type multidrug / protein/ lipid transport system, ATPase component: residues 1-596 are 41% similar to the protein in Clostridium acetobutylicum (15896527|). Residues 31-596 are 43% similar to the protein from Listeria monocytogenes (16802649|).







The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1338 (1e-109).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379367|ref|NP_721322.1|  putative ABC transporter, ATP-...  1154   0.0  
 gi|76787154|ref|YP_329972.1|  efflux ABC transporter, permea...   920   0.0  
 gi|77411191|ref|ZP_00787543.1|  ABC transporter, ATP-binding...   920   0.0  
 gi|25011443|ref|NP_735838.1|  hypothetical protein gbs1401 [...   917   0.0  
 gi|77409506|ref|ZP_00786195.1|  ABC transporter, ATP-binding...   916   0.0  
 gi|157074875|gb|ABV09558.1|  ABC-type multidrug/protein/lipi...   808   0.0  
 gi|125717326|ref|YP_001034459.1|  ABC-type multidrug transpo...   802   0.0  
 gi|55820520|ref|YP_138962.1|  multidrug ABC exporter (DrugE2...   763   0.0  
 gi|116627330|ref|YP_819949.1|  ABC-type multidrug transport ...   759   0.0  
 gi|89096301|ref|ZP_01169194.1|  probable permease protein of...   645   0.0


InterPro Summary:  InterProScan

InterPro
IPR001140
Domain
ABC transporter, transmembrane region
PF00664 [16-277]T 1.1000002989614898E-8 PF00664 ABC_membrane ABC_membrane
InterPro
IPR003439
Domain
ABC transporter related
PD000006 [491-532]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [378-565]T 4.10001399699343E-46 PF00005 ABC_tran ABC_tran
PS00211 [492-506]T 8.0E-5 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [351-589]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [377-566]T 1.0E-13 SM00382 AAA AAA
InterPro
IPR011527
Domain
ABC transporter, transmembrane region, type 1
PS50929 [17-317]T 0.0 PS50929 ABC_TM1F ABC_TM1F
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [316-598]T 2.29998420488559E-72 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19242 [1-266]T 0.0 PTHR19242 PTHR19242[283-599]T 0.0 PTHR19242 PTHR19242 PTHR19242
PTHR19242:SF91 [1-266]T 0.0 PTHR19242:SF91 PTHR19242:SF91[283-599]T 0.0 PTHR19242:SF91 PTHR19242:SF91 PTHR19242:SF91
SSF52540 [351-594]T 1.1000000000000001E-63 SSF52540 SSF52540 SSF52540
SSF90123 [5-327]T 1.9E-48 SSF90123 SSF90123 SSF90123


COGS Summary:  COGS Search
BeTs to 12 clades of COG1132
COG name: ABC-type multidrug/protein/lipid transport system, ATPase component
Functional Class: R
The phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inX
Number of proteins in this genome belonging to this COG is 16
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.8e-63.
    IPB001140A    367-413
    IPB001140B    489-527
    IPB001140C    542-571


 ProDom Summary:  Protein Domain Search
Residues 332-506 are 25% similar to a (ABC TRANSPORTER) protein domain (PD241124 which is seen in Q9U0N4_PLAF7.

Residues 163-264 are 32% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD200980 which is seen in Q9CIU5_LACLA.

Residues 184-260 are 38% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD200991 which is seen in YC73_MYCTU.

Residues 90-144 are 43% similar to a (ATP-BINDING PROTEOME COMPONENT COMPLETE) protein domain (PD412583 which is seen in Q9L4X5_BBBBB.

Residues 542-593 are 55% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD394504 which is seen in Q9ZIC8_LISMO.

Residues 78-144 are 41% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD384480 which is seen in Q9EW98_BBBBB.

Residues 431-489 are 42% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC) protein domain (PD054667 which is seen in Q9CC88_MYCLE.

Residues 544-590 are 51% similar to a (ATP-BINDING ABC TRANSPORTER TRANSMEMBRANE) protein domain (PD405975 which is seen in YC73_MYCTU.

Residues 290-360 are 39% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818 which is seen in Q9L2F3_STRCO.

Residues 433-489 are 52% similar to a (ATP-BINDING TRANSPORT TRANSMEMBRANE GLYCOPROTEIN) protein domain (PD000101 which is seen in Q9CIU5_LACLA.

Residues 368-418 are 60% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005 which is seen in Q9KDT5_BACHD.

Residues 491-534 are 70% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in Q9L2F3_STRCO.

Residues 433-487 are 47% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD387938 which is seen in Q9PR86_UREPA.


Paralogs:  Local Blast Search
SMu0836 is paralogously related (blast p-value < 1e-3) to SMu0824, SMu0987, SMu0825, SMu0476, SMu0475, SMu0986, SMu1710, SMu0837, SMu0258, SMu1064, SMu1065, SMu1724, SMu0024, SMu1950, SMu1920, SMu1246, SMu1231, SMu0517, SMu1762, SMu1003, SMu0731, SMu1949, SMu0884, SMu1068, SMu1757, SMu0971, SMu0235, SMu0418, SMu1545, SMu1288, SMu0218, SMu1751, SMu0805, SMu0916, SMu0849, SMu0786, SMu1036, SMu0390, SMu0907, SMu1518, SMu1428, SMu1037, SMu0944, SMu1517, SMu0594, SMu0374, SMu1210, SMu0335, SMu0950, SMu0596, SMu1380, SMu1079, SMu1023, SMu1316, SMu0234, SMu1093, SMu0216, SMu0224, SMu1649, SMu0976, SMu0729, SMu0752, SMu1410, SMu0164, SMu1001, SMu1811, SMu1959, SMu0823, SMu0666, SMu1306, SMu1050, SMu1686, and SMu1725 all with ATP-binding capabilities.

Pfam Summary:  Pfam Search
Residues 16 to 286 (E-value = 1.3e-10) place SMu0836 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)
Residues 378 to 565 (E-value = 4.1e-46) place SMu0836 in the ABC_tran family which is described as ABC transporter (PF00005)

 Structural Feature(s):
Feature Type  Start  Stop
cleavable  
1  
28
transmembrane  
62  
78
transmembrane  
163  
179
transmembrane  
244  
260
transmembrane  
299  
315

Top PDB Hits:
pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 83 6e-017
pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 68 4e-012

Gene Protein Sequence:
MFKIFKRLNAKEWGMVLLSTAFICLAVWMDLKTPEYMSNITTLLQTKGTT
ASDIMDPGSKMLMFSFGSFFMAVLVGFLASRTAASFTTRLRSDIFNRVMD
YSEAEIKKFSIPSLLTRTTNDLTQLQIMIVMGMQVVTRGPIMAVWALTKI
WGKSDEWTGAVGVAVLIVFIMLSVLMFVAFPRQRQVQSLTDALNSTTRES
LTGVRVVRAYNAEDYQDTKFKRENKNLTKLNLLVYRLMSLMNPVMTVVSS
GLTLAIYWIGAYLLNDIKIPMTSVTAAKGAIADRISVFSDMVVFSSYAMQ
VVVGFMMMVAIFIILPRALVSAKRINEVLALNSSVHFKEYSKADNARKGE
VEFHDVSFRYSKNSRAVIEHVSFSAKAGETVAFIGSTGSGKSTLVNLIPR
FYDATEGWIKIDGIKVQDYSHDDLNNKVGYIPQRAVLFSGTIRSNIAFGQ
SDQAPLDDAKIWEALELAQAKNFVEEKEKGLDTEVAQGGTNFSGGQKQRL
AIARALARKPEILIFDDSFSALDYKTDRILRNDLAKKTKEMTKLIVAQRI
STIMDADHILVLDQGKVVGQGTHKELLANNDIYQEIAYSQLSKEELENGK


Gene Nucleotide Sequence:  Sequence Viewer
ATGTTTAAAATTTTTAAACGTCTAAATGCTAAAGAATGGGGCATGGTTCT
CCTTAGTACTGCCTTTATCTGTTTGGCTGTCTGGATGGATTTGAAGACGC
CCGAATATATGTCCAACATTACAACCTTGCTGCAGACTAAGGGAACGACC
GCCTCAGATATTATGGATCCGGGATCTAAGATGCTCATGTTTTCATTTGG
GAGCTTTTTTATGGCCGTTCTAGTTGGTTTTTTAGCTTCAAGAACAGCTG
CTAGCTTTACGACCCGTCTTCGATCTGATATTTTCAATCGGGTTATGGAT
TATTCAGAGGCGGAAATCAAGAAATTTTCCATTCCCAGCCTTCTAACGCG
TACGACTAATGATTTGACACAGTTGCAAATCATGATCGTTATGGGAATGC
AAGTGGTGACACGCGGTCCAATCATGGCTGTTTGGGCCTTGACTAAAATC
TGGGGTAAAAGCGATGAATGGACAGGAGCAGTCGGTGTTGCCGTTTTAAT
TGTCTTTATTATGCTGTCTGTTTTGATGTTTGTCGCTTTTCCAAGACAGC
GTCAGGTGCAGAGCTTGACGGATGCTCTAAATTCTACAACCCGTGAATCT
CTGACTGGTGTTCGTGTTGTTCGGGCTTACAATGCAGAAGATTATCAGGA
CACTAAATTTAAGCGGGAAAATAAAAACCTGACGAAATTGAATTTATTGG
TCTATCGTCTGATGTCGCTAATGAATCCTGTCATGACAGTTGTTTCCAGT
GGTCTAACTTTAGCTATTTATTGGATTGGAGCTTACCTGCTCAATGATAT
TAAAATTCCTATGACGAGTGTGACAGCTGCTAAAGGAGCTATTGCTGATC
GTATCAGTGTTTTTAGTGATATGGTTGTCTTTTCATCTTATGCCATGCAG
GTTGTTGTCGGTTTTATGATGATGGTCGCTATCTTTATCATTTTACCGCG
TGCTTTAGTTTCTGCCAAACGAATTAATGAAGTATTGGCGCTTAACTCAT
CTGTACACTTCAAAGAATATTCTAAAGCAGACAATGCTCGAAAAGGAGAA
GTCGAATTTCATGATGTATCGTTTCGTTACAGTAAAAATTCTCGTGCGGT
TATTGAGCATGTGTCTTTCAGTGCTAAAGCTGGTGAGACAGTTGCTTTTA
TTGGTTCCACTGGCTCAGGAAAATCAACTCTTGTTAATCTGATTCCTCGT
TTTTATGATGCTACAGAAGGTTGGATTAAGATAGATGGAATCAAAGTGCA
AGATTACAGCCATGATGACCTCAACAATAAAGTCGGCTATATTCCGCAAA
GGGCAGTGCTTTTTAGTGGGACCATTCGTTCTAATATTGCATTTGGGCAA
AGCGATCAAGCGCCGCTTGATGATGCTAAAATTTGGGAGGCTCTTGAACT
AGCCCAAGCCAAAAACTTTGTTGAAGAAAAAGAAAAGGGTCTGGATACCG
AGGTAGCTCAAGGCGGTACCAACTTCTCTGGCGGTCAAAAGCAGCGCTTA
GCTATTGCCCGTGCACTTGCACGCAAACCAGAAATTCTTATTTTTGATGA
CTCCTTCTCAGCTCTTGATTATAAGACGGATCGCATTCTGCGAAATGATT
TGGCAAAGAAAACCAAAGAAATGACTAAGTTGATTGTAGCCCAACGTATT
TCAACTATTATGGATGCTGATCATATTTTGGTCTTAGATCAGGGAAAGGT
TGTTGGTCAAGGAACACACAAGGAATTACTGGCTAATAACGATATTTATC
AAGAAATTGCTTATTCACAACTATCTAAGGAGGAGTTAGAAAATGGAAAA
TAA

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