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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR672 IGR664 IGR670 IGR669 IGR671 IGR667 IGR666 IGR663 IGR668 IGR665 SMu0770 SMu0764 folC, - SMu0763 rplU, - SMu0771 SMu0772 SMu0768 SMu0769 ycgG, - SMu0761 SMu0765 SMu0767 thiI, - SMu0766 gshR,gor, - SMu0762 SMu0770 SMu0764 folC, - SMu0763 rplU, - SMu0771 SMu0772 SMu0768 SMu0769 ycgG, - SMu0761 SMu0765 SMu0767 thiI, - SMu0766 gshR,gor, - SMu0762 SMu0770 SMu0764 folC, - SMu0763 rplU, - SMu0771 SMu0769 ycgG, - SMu0761 SMu0765 SMu0767 thiI, - SMu0766 gshR,gor, - SMu0762 SMu0772 SMu0768


LANL Gene ID: SMu0765

GenBank Locus Tag: SMU.841

DNA Molecule Name:
1  

GenBank ID:
24379296

Gene Name:


Definition:
aminotransferase, class V; possible cysteine desulphurase

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
791892

Gene Stop:
793034

Gene Length:
1143

Molecular Weight*:
41805

pI*:
9.50

Net Charge*:
6.14

EC:
2.8.1.7  

Functional Class:
Biosynthesis of cofactors, prosthetic groups, and carriers; Other  

Gene Ontology:
Biological process
  GO:0008152    metabolic process

Molecular function
  GO:0003824    catalytic activity
  GO:0008483    transaminase activity
  GO:0030170    pyridoxal phosphate binding


Pathway: pathway table

Secondary Evidence:
Leong-Morgenthaler,P., Oliver,S.G., Hottinger,H. and Soll,D.
A Lactobacillus nifS-like gene suppresses an Escherichia coli
transaminase B mutation
Biochimie 76 (1), 45-49 (1994)
PubMed: 8031904


Comment:


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Limited matches in gapped BLAST to aminotransferase/nifs protein homolog: residues 1-380 are 72% similar to the enzyme in S.pneumoniae (gi15900763).Residues 14-365 are 50% similar to the enzyme in Lactobacillus delbrueckii (gi400539).






The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1373 (1e-169).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379296|ref|NP_721251.1|  putative aminotransferase [Str...   733   0.0  
 gi|55820499|ref|YP_138941.1|  aminotransferase (class V), pu...   586   e-166
 gi|77408223|ref|ZP_00784967.1|  cysteine desulphurase [Strep...   583   e-165
 gi|76788498|ref|YP_330014.1|  aminotransferase, class V [Str...   583   e-165
 gi|22537520|ref|NP_688371.1|  cysteine desulphurase [Strepto...   582   e-164
 gi|77406382|ref|ZP_00783443.1|  cysteine desulphurase [Strep...   582   e-164
 gi|25011485|ref|NP_735880.1|  hypothetical protein gbs1443 [...   582   e-164
 gi|81177152|ref|ZP_00876027.1|  Aminotransferase, class V [S...   577   e-163
 gi|146318430|ref|YP_001198142.1|  Cysteine sulfinate desulfi...   576   e-163
 gi|157076448|gb|ABV11131.1|  aminotransferase, class-V [Stre...   567   e-160


InterPro Summary:  InterProScan

InterPro
IPR000192
Family
Aminotransferase, class V
PF00266 [2-365]T 1.40000506907309E-59 PF00266 Aminotran_5 Aminotran_5
PS00595 [193-212]T 8.0E-5 PS00595 AA_TRANSFER_CLASS_5 AA_TRANSFER_CLASS_5
InterPro
IPR015421
Domain
Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10 [2-256]T 8.500030248090479E-77 G3DSA:3.40.640.10 PyrdxlP-dep_Trfase_major_sub1 PyrdxlP-dep_Trfase_major_sub1
InterPro
IPR015424
Domain
Pyridoxal phosphate-dependent transferase, major region
SSF53383 [1-375]T 1.1999999999999998E-94 SSF53383 PyrdxlP-dep_Trfase_major PyrdxlP-dep_Trfase_major
noIPR
unintegrated
unintegrated
PIRSF005572 [1-380]T 0.0 PIRSF005572 NifS NifS
PTHR11601 [1-380]T 9.400030710307491E-100 PTHR11601 PTHR11601 PTHR11601


COGS Summary:  COGS Search
BeTs to 12 clades of COG1104
COG name: Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes (NifS family)
Functional Class: E
The phylogenetic pattern of COG1104 is A--kYQvCeBRHuj---lINX
Number of proteins in this genome belonging to this COG is 2
Blocks Summary:  Blocks Search
No significant hits to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 50-215 are 69% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087 which is seen in Q9CI29_LACLA.

Residues 340-379 are 60% similar to a (AMINOTRANSFERASE PROTEOME COMPLETE) protein domain (PD375301 which is seen in Q9CI29_LACLA.

Residues 38-106 are 42% similar to a (AMINOTRANSFERASE PROTEOME PYRIDOXAL LYASE) protein domain (PD311278 which is seen in ISCS_PSEAE.

Residues 292-338 are 78% similar to a (LYASE PYRIDOXAL DESULFURASE PHOSPHATE 4.4.1.- CYSTEINE) protein domain (PD189309 which is seen in Q9CI29_LACLA.

Residues 2-35 are 70% similar to a (LYASE CYSTEINE DESULFURASE 4.4.1.-) protein domain (PD351786 which is seen in Q9CI29_LACLA.

Residues 108-208 are 39% similar to a (AMINOTRANSFERASE V PROTEOME COMPLETE) protein domain (PD393971 which is seen in Q9RXU1_DEIRA.

Residues 220-254 are 71% similar to a (LYASE PHOSPHATE 4.4.1.- PYRIDOXAL DESULFURASE CYSTEINE) protein domain (PD001054 which is seen in Q9CI29_LACLA.


Paralogs:  Local Blast Search
SMu0765 is paralogously related (blast p-value < 1e-3) to SMu0959, a predicted iron-sulfur cofactor synthesis protein and SMu0226, a predicted NifS protein homolog, class-V aminotransferase.


Pfam Summary:  Pfam Search
Residues 10 to 365 (E-value = 1.4e-84) place SMu0765 in the Aminotran_5 family which is described as Aminotransferase class-V (PF00266)

 Top PDB Hits:
pdb1ECXB Chain B, Nifs-Like Protein >gi7546479pdb1ECXA Ch... 265 9e-072
pdb1EG5B Chain B, Nifs-Like Protein >gi7546280pdb1EG5A Ch... 256 3e-069
pdb1C0NA Chain A, Csdb Protein, Nifs Homologue 76 9e-015

Gene Protein Sequence:
MIYFDNSATTLPYPEAIKTYEEVATKIFGNPSSLHQLGSQSSRILQASRQ
QIAELLGKRTDEVFFTSGGTEGDNWVIKGLAFEKQRYGKHIIVSDIEHPA
VKESAKWLQTQGFEVDFAPVDKKGFVKVDVLAKLLRPDTILVSIMAVNNE
IGSVQPIKAISKLLADKASISFHVDAVQAIGKIATDDYLTDRVDFATFSG
HKFHSVRGVGFIYKKAGKKISPLLNGGGQEAGFRSTTENVAGIAATVKAL
RIVLDKAKIGQKQLLAMKRILFDSLSHYDDVILFSEMEYFAPNILTFGIK
GVRGEVLVHAFEEHDIYISTTSACSSKAGKPAGTLISMGISSKLAQTAVR
LSLDEDNDMSQVEQFLTIFKQIYEKTKKVR

Gene Nucleotide Sequence:  Sequence Viewer
ATGATTTATTTTGATAATTCAGCAACAACACTTCCTTATCCGGAAGCAAT
CAAAACCTATGAAGAAGTGGCAACTAAAATTTTTGGCAATCCTTCTAGCT
TGCATCAATTAGGTAGTCAGTCAAGCAGGATTTTGCAGGCATCTCGTCAG
CAAATTGCAGAGCTTTTAGGAAAAAGGACAGATGAAGTCTTTTTTACTTC
AGGCGGTACAGAAGGAGATAACTGGGTCATTAAAGGTCTGGCCTTTGAAA
AGCAGCGTTACGGTAAACATATTATTGTATCTGACATTGAACATCCAGCA
GTAAAAGAATCTGCTAAATGGTTGCAAACTCAGGGCTTTGAGGTTGATTT
TGCCCCTGTTGACAAAAAGGGTTTTGTCAAAGTTGATGTCTTGGCAAAAC
TATTGCGACCTGATACTATTTTAGTTTCTATCATGGCTGTTAATAATGAG
ATTGGTTCTGTTCAACCGATTAAAGCAATTTCAAAGCTTTTAGCTGATAA
GGCTAGTATTTCTTTTCATGTAGATGCTGTACAGGCAATTGGCAAGATAG
CAACGGATGATTACTTGACTGATCGTGTTGACTTTGCGACTTTTTCTGGT
CATAAATTTCATTCTGTTCGTGGTGTTGGCTTTATTTATAAGAAAGCTGG
GAAGAAGATTTCTCCTCTTTTGAACGGTGGCGGACAAGAAGCTGGCTTTC
GAAGCACCACCGAAAATGTAGCGGGGATTGCGGCAACGGTCAAAGCCTTG
AGAATTGTTCTTGATAAAGCCAAAATAGGACAAAAACAACTGTTGGCTAT
GAAGAGAATTCTTTTTGATAGCCTATCGCATTATGATGATGTTATTCTTT
TTTCAGAAATGGAATATTTTGCTCCCAATATTTTAACTTTTGGTATCAAA
GGAGTGCGTGGTGAGGTATTGGTTCATGCCTTTGAAGAACATGATATTTA
CATTTCAACGACATCAGCTTGTTCCTCCAAGGCTGGTAAACCTGCGGGCA
CCCTCATTTCAATGGGAATTTCCAGCAAGCTTGCTCAAACAGCCGTTCGC
CTTAGTCTTGATGAGGATAATGACATGAGTCAGGTGGAGCAATTTTTAAC
CATTTTCAAACAAATTTATGAAAAAACAAAAAAAGTAAGGTAA

Los Alamos National Laboratory • Est 1943

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