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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR627 IGR633 IGR631 IGR628 IGR629 IGR630 IGR635 IGR632 IGR634 SMu0724 SMu0725 SMu0731 ykhF, - SMu0729 glnP, - SMu0732 SMu0728 SMu0723 SMu0726 ytfG, - SMu0722 SMu0730 obg, - SMu0727 SMu0724 SMu0725 SMu0731 ykhF, - SMu0729 glnP, - SMu0732 SMu0728 SMu0723 SMu0726 ytfG, - SMu0722 SMu0730 obg, - SMu0727 SMu0725 SMu0731 ykhF, - SMu0729 glnP, - SMu0732 SMu0724 SMu0728 SMu0723 SMu0726 ytfG, - SMu0722 SMu0730 obg, - SMu0727


LANL Gene ID: SMu0729

GenBank Locus Tag: SMU.803c

DNA Molecule Name:
1  

GenBank ID:
24379260

Gene Name:
ykhF  

Definition:
ABC transporter, ATP-binding protein

Cellular Location:
Cytoplasm, Membrane [Evidence]

Gene Start:
749466

Gene Stop:
747961

Gene Length:
1506

Molecular Weight*:
57660

pI*:
7.70

Net Charge*:
3.46

EC:
 

Functional Class:
Transport and binding proteins; ABC Superfamily: ATP-binding protein  

Gene Ontology:
Molecular function
  GO:0000166    nucleotide binding
  GO:0005524    ATP binding
  GO:0016887    ATPase activity
  GO:0017111    nucleoside-triphosphatase activity


Pathway: pathway table

Comment:
This sequence contains two nucleotide binding domains.



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Several matches in gapped BLAST to ABC transporter, ATP-binding proteins: residues 1-501 are 41% similar to the protein in S.pneumoniae (15901142|). Residues 1-488 are 25% and residues 29-272 are 26% similar to the protein from Lactococcus lactis subsp. lactis (15673044|).






The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1340 (5e-38).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379260|ref|NP_721215.1|  putative ABC transporter, ATP-...   947   0.0  
 gi|125718188|ref|YP_001035321.1|  ATPase components of ABC t...   453   e-125
 gi|157075702|gb|ABV10385.1|  ABC transporter, ATP-binding pr...   451   e-125
 gi|81096059|ref|ZP_00874409.1|  ABC transporter [Streptococc...   400   e-109
 gi|146318686|ref|YP_001198397.1|  ATPase component of ABC tr...   382   e-104
 gi|149007050|ref|ZP_01830719.1|  ABC transporter, ATP-bindin...   382   e-104
 gi|149002656|ref|ZP_01827588.1|  pyrimidine regulatory prote...   379   e-103
 gi|15901142|ref|NP_345746.1|  ABC transporter, ATP-binding p...   379   e-103
 gi|149012339|ref|ZP_01833408.1|  pyrimidine regulatory prote...   379   e-103
 gi|148985182|ref|ZP_01818421.1|  pyrimidine regulatory prote...   377   e-102


InterPro Summary:  InterProScan

InterPro
IPR003439
Domain
ABC transporter related
PD000006 [130-172]T 0.0 PD000006 ABC_transporter[423-464]T 0.0 PD000006 ABC_transporter ABC_transporter
PF00005 [29-202]T 7.600000111157909E-25 PF00005 ABC_tran[339-495]T 7.00000734129907E-19 PF00005 ABC_tran ABC_tran
PS00211 [423-437]? 0.0 PS00211 ABC_TRANSPORTER_1 ABC_TRANSPORTER_1
PS50893 [2-226]T 0.0 PS50893 ABC_TRANSPORTER_2 ABC_TRANSPORTER_2
InterPro
IPR003593
Domain
AAA+ ATPase, core
SM00382 [28-203]T 1.1000000000000098E-9 SM00382 AAA[339-501]T 1.3000000000000099E-5 SM00382 AAA AAA
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.300 [4-246]T 1.1000015067164301E-28 G3DSA:3.40.50.300 G3DSA:3.40.50.300[277-498]T 3.00000067992862E-19 G3DSA:3.40.50.300 G3DSA:3.40.50.300 G3DSA:3.40.50.300
PTHR19211 [96-258]T 7.200027197789859E-61 PTHR19211 PTHR19211[276-498]T 7.200027197789859E-61 PTHR19211 PTHR19211 PTHR19211
PTHR19211:SF11 [96-258]T 7.200027197789859E-61 PTHR19211:SF11 PTHR19211:SF11[276-498]T 7.200027197789859E-61 PTHR19211:SF11 PTHR19211:SF11 PTHR19211:SF11
SSF52540 [2-206]T 1.6E-36 SSF52540 SSF52540[320-498]T 4.3E-27 SSF52540 SSF52540 SSF52540


COGS Summary:  COGS Search
BeTs to 10 clades of COG0488
COG name: ATPase components of ABC transporters with duplicated ATPase domains
Functional Class: R
The phylogenetic pattern of COG0488 is ----Y--CEBRHuj--olinx
Number of proteins in this genome belonging to this COG is 4
Blocks Summary:  Blocks Search
***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.3e-12.
    IPB001140A    18-64
    IPB001140B    127-165
    IPB001140A    329-375
    IPB001140B    420-458


 ProDom Summary:  Protein Domain Search
Residues 130-174 are 51% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD250554 which is seen in Q9KBA3_BACHD.

Residues 127-173 are 44% similar to a (PROTEOME BINDING ATP-BINDING COMPLETE) protein domain (PD335182 which is seen in Q9X7B1_MYCLE.

Residues 173-481 are 22% similar to a (ATP-BINDING ABC TRANSPORTER) protein domain (PD068705 which is seen in Q9ZC01_STRCO.

Residues 372-481 are 32% similar to a (ATP-BINDING) protein domain (PD397028 which is seen in Q53712_STRAT.

Residues 130-172 are 55% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006 which is seen in YDIF_BACSU.


Paralogs:  Local Blast Search
SMu0729 is paralogously related (blast p-value < 1e-3) to SMu1306, SMu0823, SMu1959, SMu1757, SMu0418, SMu1380, SMu1811, SMu0731, SMu0916, SMu0824, SMu0218, SMu0884, SMu0164, SMu0976, SMu1710, SMu0666, SMu1079, SMu1517, SMu0786, SMu0390, SMu1545, SMu1246, SMu1231, SMu0475, SMu1068, SMu0836, SMu0517, SMu0234, SMu1751, SMu1920, SMu0258, SMu1410, SMu0907, SMu1037, SMu0849, SMu1065, SMu0971, SMu1950, SMu1762, SMu1288, SMu0950, SMu1316, SMu1023, SMu1003, SMu0944, SMu1001, SMu0987, SMu0216, SMu1064, SMu0805, SMu1036, SMu0024, SMu1518, SMu1949, SMu0752, SMu1210, SMu1093, SMu0224, SMu1428, SMu0476, SMu0235, SMu0986, SMu0594, SMu0825, SMu1724, SMu1649, SMu0335, SMu1202, SMu0596, SMu0374, and SMu1050 all with ATP-binding capabilities.

Pfam Summary:  Pfam Search
Residues 29 to 202 (E-value = 5.6e-23) place SMu0729 in the ABC_tran family which is described as ABC transporter (PF00005)
Residues 339 to 495 (E-value = 1e-14) place SMu0729 in the ABC_tran family which is described as ABC transporter (PF00005)

 Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MLQIQNLTITHQKDLQILVKDLSLVVNPGEKLAIIGEEGTGKSTLLKTIL
SPELIGNYADVTGTIQNSFNRIGYLPQNMEDKDLTLTIKNYIYHDIDFDH
FDFNLFYQMAERFQFDSQRFDDDVQSISSLSGGEKLKLQLLKMLAYNPDL
LLFDEPSSDLDLDTMTWLEYFISQTNKTIIFISHDEALLRKCATAILHLE
LLKKRQNPRASYFQGNYKNYKSWRKNSFNKQLQVAQKEREEHTKKMERHH
RIHQSVEHQLRNTKNDVAGRLLAKKMKNVLSQGKRYAKEAKNFTEIPQDM
DAINLFFTKVKSLPANKVLLHWENRPLPTGQVINFDIRGQDKLVITGQNG
IGKTRLLKEVLTELTTKSDLSICYMPQNYEELLDGKLSALQFLKESAGEE
SCRNLLASLQFTRDEITHSVASLSGGQKAKLFLAQMVLESSNVLLLDEPT
RHFSPTSQPLIRQLFKDFPGCIISVSHDRQFIDEVVNKHYKLNQTELVNL
D

Gene Nucleotide Sequence:  Sequence Viewer
ATGTTACAGATTCAAAATCTTACCATTACGCACCAAAAAGATCTACAAAT
ACTCGTTAAAGATTTGTCCTTAGTCGTCAATCCTGGTGAGAAATTAGCTA
TTATCGGGGAGGAAGGGACCGGTAAGTCTACTCTCCTCAAGACTATACTC
AGCCCTGAGCTGATTGGCAACTACGCTGATGTGACAGGTACTATTCAGAA
TAGTTTTAACCGAATCGGTTACTTGCCACAAAACATGGAAGATAAAGATT
TAACTCTAACCATTAAAAACTATATTTACCATGATATAGATTTTGACCAT
TTTGATTTTAATCTTTTTTATCAAATGGCAGAGCGTTTTCAGTTTGACAG
TCAGCGATTTGACGACGATGTCCAGAGCATTTCTAGTCTTTCTGGCGGAG
AGAAATTAAAACTGCAGCTGCTGAAAATGCTTGCCTACAATCCTGACTTA
CTTCTTTTTGATGAGCCTTCTAGTGACTTGGATCTGGACACAATGACTTG
GCTGGAGTATTTTATCAGCCAGACAAACAAAACCATTATTTTCATTTCTC
ATGATGAAGCACTACTTAGGAAATGTGCTACTGCTATCCTTCATTTGGAA
TTGCTCAAGAAACGCCAAAACCCCCGCGCCAGCTATTTCCAAGGAAACTA
TAAGAACTACAAAAGTTGGCGAAAGAATAGCTTTAATAAGCAGCTTCAAG
TCGCGCAAAAAGAACGTGAGGAACATACCAAAAAAATGGAACGCCACCAC
CGCATTCATCAGAGTGTGGAACATCAACTGCGCAACACCAAAAATGATGT
TGCAGGTCGGCTGCTGGCCAAGAAAATGAAAAATGTCCTGTCTCAGGGAA
AACGCTATGCCAAGGAGGCCAAAAACTTCACGGAAATTCCGCAGGATATG
GATGCTATTAACCTCTTTTTCACGAAAGTTAAATCTTTGCCTGCCAACAA
AGTTCTACTGCATTGGGAAAATCGTCCTTTGCCGACAGGACAAGTAATTA
ATTTTGACATTCGCGGTCAGGATAAGCTGGTTATCACAGGACAAAATGGA
ATTGGCAAGACGCGCCTGCTTAAAGAGGTTCTTACCGAGTTAACCACAAA
ATCAGATCTATCTATCTGTTATATGCCACAAAACTACGAAGAGTTACTGG
ATGGTAAGCTGTCTGCTCTGCAATTTCTCAAAGAAAGTGCGGGCGAAGAA
TCTTGCCGTAATCTTCTAGCTAGTCTCCAATTCACACGGGATGAAATCAC
GCACTCTGTTGCAAGCTTATCGGGCGGTCAGAAGGCTAAACTCTTTTTAG
CTCAAATGGTCTTGGAAAGCAGCAATGTCCTGCTGCTGGACGAGCCAACC
CGCCACTTTTCACCAACTAGTCAGCCTCTTATTCGACAGCTTTTCAAGGA
TTTTCCGGGTTGTATTATCAGCGTATCGCACGATAGACAATTTATAGATG
AAGTCGTTAATAAACACTACAAATTAAATCAAACAGAATTAGTGAATCTA
GACTAA

Los Alamos National Laboratory • Est 1943

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