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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR613 IGR617 IGR614 IGR619 IGR616 IGR612 IGR618 SMu0703 SMu0710 pheA, - SMu0713 aroE, - SMu0706 aroB, - SMu0707 tyrA, - SMu0709 SMu0704 aroC, - SMu0708 aroA, - SMu0711 psr, - SMu0714 SMu0703 SMu0710 pheA, - SMu0713 aroE, - SMu0706 aroB, - SMu0707 tyrA, - SMu0709 SMu0704 aroC, - SMu0708 aroA, - SMu0711 psr, - SMu0714 SMu0703 SMu0710 pheA, - SMu0713 aroE, - SMu0706 aroB, - SMu0707 tyrA, - SMu0709 SMu0704 aroC, - SMu0708 aroA, - SMu0711 psr, - SMu0714 aroK, - SMu0712 aroD, - SMu0705 aroK, - SMu0712 aroD, - SMu0705


LANL Gene ID: SMu0708

GenBank Locus Tag: SMU.780

DNA Molecule Name:
1  

GenBank ID:
24379239

Gene Name:
aroC  

Definition:
chorismate synthase

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
731526

Gene Stop:
732692

Gene Length:
1167

Molecular Weight*:
42629

pI*:
6.70

Net Charge*:
-1.27

EC:
4.6.1.4  

Functional Class:
Amino acid biosynthesis; Aromatic amino acid family  

Gene Ontology:
Biological process
  GO:0009073    aromatic amino acid family biosynthetic process

Molecular function
  GO:0004107    chorismate synthase activity


Pathway: pathway table
Phenylalanine, tyrosine and tryptophan biosynthesis

Secondary Evidence:
Horsburgh,M.J., Foster,T.J., Barth,P.T. and Coggins,J.R.
Chorismate synthase from Staphylococcus aureus
Microbiology 142 (Pt 10), 2943-2950 (1996)
PubMed: 8885411


Comment:
For other 'aro' genes see SMu0705 (aroD); SMu0706 (aroE); SMu0707 (aroB); SMu0711 (aroA); SMu0712 (aroK); SMu1672 (aroG) and SMu1673 (aroH) (aroG).

From Genbank: [gi:12407965]
This enzyme catalyzes the seventh step in the biosynthesis
of chorismate within the aromatic amino acid biosynthetic
pathway (Shikimate pathway).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Several matches in gapped BLAST to chorismate synthase: residues 1-388 are 73% similar to the enzyme in S.pneumoniae (15901228|) and are 67% similar to the protein from Lactococcus lactis subsp.lactis (15673734|).






The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1377 (1e-148).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379239|ref|NP_721194.1|  chorismate synthase [Streptoco...   695   0.0  
 gi|157075812|gb|ABV10495.1|  chorismate synthase [Streptococ...   618   e-175
 gi|125718278|ref|YP_001035411.1|  Chorismate synthase, putat...   616   e-175
 gi|81096396|ref|ZP_00874741.1|  Chorismate synthase [Strepto...   605   e-171
 gi|76787025|ref|YP_330018.1|  chorismate synthase [Streptoco...   578   e-163
 gi|25011489|ref|NP_735884.1|  chorismate synthase [Streptoco...   578   e-163
 gi|22537524|ref|NP_688375.1|  chorismate synthase [Streptoco...   577   e-163
 gi|55820720|ref|YP_139162.1|  chorismate synthase [Streptoco...   571   e-161
 gi|148989496|ref|ZP_01820855.1|  chorismate synthase [Strept...   563   e-159
 gi|148997572|ref|ZP_01825177.1|  chorismate synthase [Strept...   563   e-159


InterPro Summary:  InterProScan

InterPro
IPR000408
Repeat
Regulator of chromosome condensation, RCC1
PS00626 [58-68]F 0.0 PS00626 RCC1_2 RCC1_2
InterPro
IPR000453
Family
Chorismate synthase
PD002941 [30-355]T 0.0 PD002941 Chorismate_synth Chorismate_synth
PTHR21085 [1-388]T 0.0 PTHR21085 Chorismate_synth Chorismate_synth
PF01264 [1-366]T 0.0 PF01264 Chorismate_synt Chorismate_synt
TIGR00033 [1-369]T 0.0 TIGR00033 aroC aroC
PS00787 [7-22]T 8.0E-5 PS00787 CHORISMATE_SYNTHASE_1 CHORISMATE_SYNTHASE_1
PS00788 [129-145]T 8.0E-5 PS00788 CHORISMATE_SYNTHASE_2 CHORISMATE_SYNTHASE_2
PS00789 [337-353]T 8.0E-5 PS00789 CHORISMATE_SYNTHASE_3 CHORISMATE_SYNTHASE_3
noIPR
unintegrated
unintegrated
SSF103263 [1-388]T 0.0 SSF103263 SSF103263 SSF103263


COGS Summary:  COGS Search
BeTs to 12 clades of COG0082
COG name: Chorismate synthase
Functional Class: E
The phylogenetic pattern of COG0082 is amt-yqvcebrhuj----in-
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
***** IPB000453 (Chorismate synthase) with a combined E-value of 6.1e-104.
    IPB000453A    1-42
    IPB000453B    48-72
    IPB000453C    107-135
    IPB000453D    238-274
    IPB000453E    288-316
    IPB000453F    336-360


 ProDom Summary:  Protein Domain Search
Residues 2-362 are 68% similar to a (CHORISMATE SYNTHASE LYASE BIOSYNTHESIS) protein domain (PD002941 which is seen in AROC_LACLA.


Paralogs:  Local Blast Search
SMu0708 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
Residues 1 to 366 (E-value = 5e-161) place SMu0708 in the Chorismate_synt family which is described as Chorismate synthase (PF01264)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
155  
171
transmembrane  
342  
358

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MRYFTAGESHGPRLTAIIEGVPAGLPLTADYINAELRRRQGGYGRGGRMK
IESDQVEITSGVRHGLTMGSPITLNVTNRDFKNWTEIMSAADIEDKKKSI
RKLTKPRPGHADLVGGMKYRFSDLRNSLERSSARETTMRVAVGSVAKRLL
EELEITIASHVVVLGGIEVDVPENLTVAEIKERASQSEISVVNQEHEQEI
KDYIDQIKKEGNTIGGIIETVVGGVPVGLGSYVQWDRKLDAQIAQGVVSI
NAFKGVEFGLGFKDGYLKGSYVMDEITWSKEDGYRRKSNNLGGFEGGMTN
GQPIVVRGVMKPIPTLYKPLMSVDIETHEPYKASVERSDPTAVPAAAVVM
EGVVATVLATEILNKFSSDNMEELKEAVKSHQKFIKEF

Gene Nucleotide Sequence:  Sequence Viewer
ATGAGATATTTTACAGCTGGGGAATCGCATGGTCCTCGTCTGACAGCTAT
TATTGAAGGAGTGCCAGCAGGTCTTCCTCTAACAGCCGACTATATTAATG
CTGAATTAAGGCGGCGGCAAGGAGGTTATGGTCGTGGCGGCCGTATGAAG
ATTGAATCTGATCAAGTGGAAATCACTTCAGGTGTTCGCCATGGTTTGAC
TATGGGAAGTCCGATTACACTCAATGTCACTAATCGTGATTTTAAAAATT
GGACTGAAATCATGAGTGCTGCTGATATTGAGGATAAGAAAAAATCAATT
CGAAAATTAACCAAACCCCGTCCGGGACATGCAGATTTGGTTGGTGGTAT
GAAATATCGTTTTTCTGATTTGCGCAACAGTTTGGAGCGCTCAAGTGCGC
GTGAAACAACTATGCGTGTGGCAGTGGGATCAGTAGCTAAACGTCTTTTA
GAAGAACTTGAGATAACTATTGCTAGCCACGTTGTTGTTTTGGGCGGCAT
TGAAGTTGATGTTCCTGAAAATCTGACAGTAGCTGAGATTAAAGAACGAG
CAAGTCAATCTGAAATTTCCGTTGTTAACCAAGAACATGAGCAAGAAATC
AAGGATTATATTGATCAGATTAAAAAAGAAGGCAACACTATCGGCGGTAT
TATTGAAACTGTTGTTGGTGGTGTTCCAGTTGGTTTAGGCTCTTATGTTC
AATGGGATCGCAAATTAGATGCCCAAATAGCTCAAGGAGTTGTTTCCATC
AATGCCTTCAAGGGTGTTGAATTTGGCTTAGGCTTTAAGGATGGTTATCT
CAAAGGCAGCTATGTCATGGATGAGATTACTTGGTCTAAAGAAGATGGCT
ATAGGCGTAAGTCCAACAATCTTGGTGGTTTTGAAGGCGGTATGACTAAT
GGACAGCCTATTGTTGTTCGTGGGGTTATGAAGCCTATTCCGACACTTTA
TAAGCCTTTGATGAGTGTTGATATTGAAACACACGAACCATATAAGGCCA
GTGTTGAACGTTCGGACCCAACAGCTGTTCCCGCCGCTGCAGTAGTTATG
GAAGGAGTCGTTGCGACAGTTTTAGCAACAGAAATTTTGAATAAGTTTTC
TTCAGATAATATGGAAGAGCTAAAAGAAGCTGTGAAAAGCCATCAAAAAT
TTATCAAAGAATTTTAA

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