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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR487 IGR488 IGR489 IGR490 IGR493 IGR492 IGR491 IGR494 SMu0564 yheN, - SMu0565 SMu0563 sod,sodA, - SMu0571 SMu0569 plsC,yhdO, - SMu0566 holA, - SMu0570 SMu0572 comEC,celB, - SMu0568 SMu0564 yheN, - SMu0565 SMu0563 sod,sodA, - SMu0571 SMu0569 plsC,yhdO, - SMu0566 holA, - SMu0570 SMu0572 comEC,celB, - SMu0568 yheN, - SMu0565 SMu0563 SMu0564 sod,sodA, - SMu0571 SMu0569 plsC,yhdO, - SMu0566 holA, - SMu0570 SMu0572 comEC,celB, - SMu0568 comEA,celA, - SMu0567 comEA,celA, - SMu0567


LANL Gene ID: SMu0568

GenBank Locus Tag: SMU.626

DNA Molecule Name:
1  

GenBank ID:
24379099

Gene Name:
comEC  celB  

Definition:
competence protein; possible integral membrane protein

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
583867

Gene Stop:
586101

Gene Length:
2235

Molecular Weight*:
85507

pI*:
10.40

Net Charge*:
31.36

EC:
 

Functional Class:
Cellular processes; DNA transformation  

Gene Ontology:
Biological process
  GO:0030420    establishment of competence for transformation

Cellular component
  GO:0016020    membrane
  GO:0016021    integral to membrane

Molecular function
  GO:0016787    hydrolase activity


Pathway: pathway table

Secondary Evidence:
Pestova,E.V. and Morrison,D.A.
Isolation and characterization of three Streptococcus pneumoniae
transformation-specific loci by use of a lacZ reporter insertion
vector
J. Bacteriol. 180 (10), 2701-2710 (1998)
PubMed: 9573156


Comment:
For other 'cel' genes see SMu0567 (celA).

For other 'com' genes see SMu0567 (comEA); SMu0138 (comR); SMu1814 (comX1);SMu0258 (comA); SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB); SMu1802 (comYC);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD).




View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Several matches in gapped BLAST to competence proteins:residues 4-744 are 46% similar to the enzyme in S.pyogenes (gi13622508). Residues 3-744 are 46% similar to the protein from S.pneumoniae (gi15900832).






The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0782 (0.0).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24379099|ref|NP_721054.1|  putative competence protein [S...  1378   0.0  
 gi|76787621|ref|YP_329529.1|  DNA internalization-related co...   793   0.0  
 gi|25010857|ref|NP_735252.1|  hypothetical protein gbs0802 [...   791   0.0  
 gi|22536946|ref|NP_687797.1|  DNA internalization-related co...   791   0.0  
 gi|77413582|ref|ZP_00789769.1|  DNA internalization-related ...   791   0.0  
 gi|77406950|ref|ZP_00783970.1|  DNA internalization-related ...   790   0.0  
 gi|146318308|ref|YP_001198020.1|  Predicted membrane metal-b...   783   0.0  
 gi|157075011|gb|ABV09694.1|  DNA internalization-related com...   770   0.0  
 gi|81177326|ref|ZP_00876165.1|  ComEC/Rec2-related protein:D...   761   0.0  
 gi|77408884|ref|ZP_00785610.1|  DNA internalization-related ...   746   0.0


InterPro Summary:  InterProScan

InterPro
IPR001279
Domain
Beta-lactamase-like
PF00753 [493-699]T 9.5e-14 PF00753 Lactamase_B Lactamase_B
InterPro
IPR004477
Domain
ComEC/Rec2-related protein
PF03772 [214-460]T 1.2e-43 PF03772 Competence Competence
TIGR00360 [235-396]T 5.5e-11 TIGR00360 ComEC_N-term: ComEC/Rec2-related protein ComEC_N-term: ComEC/Rec2-related protein
InterPro
IPR004797
Family
DNA internalization-related competence protein ComEC/Rec2
TIGR00361 [69-728]T 1.8e-69 TIGR00361 ComEC_Rec2: DNA internalization-related com ComEC_Rec2: DNA internalization-related com
InterPro
IPR006741
Family
Accessory gene regulator B
SM00793 [365-497]T 1.1e+02 SM00793 no description no description
noIPR
unintegrated
unintegrated
signalp [1-45]? NA signalp signal-peptide signal-peptide
tmhmm [10-44]? NA tmhmm transmembrane_regions[50-68]? NA tmhmm transmembrane_regions[229-249]? NA tmhmm transmembrane_regions[275-293]? NA tmhmm transmembrane_regions[308-323]? NA tmhmm transmembrane_regions[329-349]? NA tmhmm transmembrane_regions[369-389]? NA tmhmm transmembrane_regions[395-415]? NA tmhmm transmembrane_regions[435-455]? NA tmhmm transmembrane_regions transmembrane_regions


COGS Summary:  COGS Search
BeTs to 8 clades of COG0658
COG name: Uncharacterized BCR, ComEC family
Functional Class: S
The phylogenetic pattern of COG0658 is -----qvcebrhujgpolin-
Number of proteins in this genome belonging to this COG is 1
Blocks Summary:  Blocks Search
No significant hits to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 207-373 are 30% similar to a (MG316 TRANSMEMBRANE H08_ORF369 HOMOLOG) protein domain (PD040333 which is seen in Y316_MYCGE.

Residues 262-439 are 43% similar to a (COMPETENCE PROTEOME COMPLETE COME) protein domain (PD128123 which is seen in O85198_STRPN.

Residues 626-731 are 55% similar to a (COMPLETE PROTEOME COMPETENCE) protein domain (PD017552 which is seen in Q9CER4_LACLA.

Residues 143-261 are 56% similar to a (PROTEOME COMPLETE COMPETENCE) protein domain (PD006990 which is seen in O85198_STRPN.

Residues 11-129 are 35% similar to a (COMPETENCE PROTEOME COMPLETE COMEC) protein domain (PD183539 which is seen in O85198_STRPN.

Residues 479-579 are 58% similar to a (COMPETENCE COMPLETE PROTEOME) protein domain (PD414978 which is seen in O85198_STRPN.


Paralogs:  Local Blast Search
SMu0568 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search
Residues 214 to 460 (E-value = 8.5e-44) place SMu0568 in the Competence family which is described as Competence protein (PF03772)
Residues 493 to 699 (E-value = 1.1e-11) place SMu0568 in the Lactamase_B family which is described as Metallo-beta-lactamase superfamily (PF00753)

 Structural Feature(s):
Feature Type  Start  Stop
uncleavable  
1  
45
transmembrane  
8  
24
transmembrane  
27  
43
transmembrane  
50  
66
transmembrane  
235  
251
transmembrane  
273  
289
transmembrane  
308  
324
transmembrane  
327  
343
transmembrane  
352  
368
transmembrane  
377  
393
transmembrane  
396  
412
transmembrane  
441  
457
transmembrane  
463  
479

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MLIRFFPLKPIYLAFLTVLLYFCIHCFSFLPVGLFILALVFLVFQYDRQI
CIKTLLFLLPFAAFFFYFHQKRQSEYQIVPRQVQKLIIIPDTLSVNGDNL
SFRAKSGHWTYQVFYKLKSETEKHYFEQLWQTAEIQVTADVVEAEEQRNF
KGFDYRNYLKMQGIYRIVNVTDIKTIKLSSKRFWFARLHEWRRRALVSIQ
SKFPDPMKHYMTGLLFGYLDKSFDEMNAIYSSLGIIHLFALSGMQVSFFI
GKFRYLGLRLGIRQEYMNAIQLPFSLLYAGLTGFAVSVVRSLIQGNLTHF
GFKKQDNFALTLFVMFFLIPNFLLTTGGVLSFAYAFILIMIDFETLSLLK
RILFQTFSLSLGILPLLMWYFSSFQPLSILLTILFSFIFDNLMLPFLTLA
YFLSPFVSLACFNPAFRLLERIIVQIHLIFSRPFILGSPTLPILLLLLCL
LALLYDFRQKKRVVLVLSSILALLFFISKNPLTNEVTIVDIGQGDSILLR
DISSKTILIDVGGKVTFGQTDKWRRRISDTNAEKTLIPYLKSRGIDKIDQ
LVLTHTDTDHMGDMEVVAKAFHVGEVLVSPGSLTKANFVSKLRRMKVKVH
ITKPGETLSIMGSHLQVLYPLKIGDGGNNDSIVLYGRLLGLNFLFTGDLE
KEGEAELLKTYPNLKVDVLKAGHHGSKGSSSPELLAQIEPKIALISAGKN
NRYKHPHQETLDRFAQIKSRIYRTDQEGAIRFKGLKHWQIETVR

Gene Nucleotide Sequence:  Sequence Viewer
GTGTTGATTAGGTTTTTTCCTCTCAAACCAATCTATTTAGCCTTTTTAAC
TGTTTTGCTTTATTTTTGTATTCACTGCTTTTCTTTTTTGCCAGTTGGCC
TATTTATTTTAGCTTTAGTCTTTCTTGTTTTTCAATATGATAGGCAAATC
TGTATCAAAACACTTTTGTTTTTATTGCCTTTTGCCGCTTTCTTTTTCTA
TTTTCACCAAAAAAGGCAAAGCGAGTATCAAATAGTACCCAGACAGGTTC
AAAAGTTAATTATCATTCCAGATACGCTTAGTGTCAATGGAGATAACTTA
AGTTTTCGAGCAAAATCAGGTCATTGGACTTATCAGGTCTTTTATAAATT
AAAATCTGAAACAGAGAAACATTATTTTGAACAATTATGGCAGACAGCAG
AAATTCAAGTGACAGCAGATGTTGTAGAAGCAGAAGAGCAGCGTAATTTC
AAGGGATTCGATTATAGAAACTATTTAAAGATGCAGGGAATTTACCGAAT
TGTTAATGTTACAGACATTAAAACAATTAAACTGAGTTCTAAACGCTTCT
GGTTTGCTCGTTTGCATGAATGGCGACGAAGAGCTTTGGTATCTATTCAG
TCAAAATTTCCAGACCCCATGAAACACTATATGACTGGTCTGCTTTTTGG
CTATTTAGATAAATCCTTTGATGAAATGAATGCTATTTATTCTAGCTTAG
GTATTATTCACCTTTTTGCTTTGTCAGGTATGCAGGTTAGTTTTTTCATT
GGGAAATTTCGTTATTTGGGCTTGCGTTTAGGTATTAGACAGGAATACAT
GAATGCTATTCAGCTGCCCTTTTCTTTGCTTTATGCTGGTTTGACTGGCT
TTGCAGTATCCGTTGTGCGTAGTTTGATTCAAGGTAATCTTACTCATTTT
GGTTTTAAAAAGCAGGATAACTTTGCTCTAACCTTATTTGTTATGTTTTT
CCTGATACCCAATTTCTTATTAACAACAGGAGGTGTGCTTAGTTTTGCCT
ATGCTTTTATTCTAATCATGATTGATTTTGAGACTTTGTCACTCTTAAAG
CGGATTCTATTTCAAACCTTTTCTCTTTCTTTAGGGATTTTACCGTTATT
GATGTGGTATTTTAGCAGTTTTCAGCCCTTGTCTATCCTATTAACTATCC
TCTTTTCTTTTATTTTTGATAACTTGATGTTGCCTTTTTTGACACTTGCT
TATTTTCTGTCACCTTTTGTATCACTTGCCTGCTTCAATCCAGCTTTTAG
ATTATTAGAAAGAATAATTGTTCAAATTCACCTAATCTTTAGTCGTCCTT
TTATTTTGGGCAGTCCGACTTTGCCTATTCTCTTACTTTTATTGTGCCTT
TTAGCTTTACTCTATGATTTTCGTCAGAAAAAAAGGGTAGTGTTAGTACT
TAGTAGCATTCTCGCCCTGTTATTTTTCATCAGTAAAAATCCTTTGACTA
ATGAAGTGACTATTGTTGATATTGGTCAGGGGGATAGTATTCTTCTTCGG
GATATCAGCAGTAAGACTATTTTAATTGATGTAGGAGGAAAAGTAACTTT
TGGACAGACTGATAAATGGCGGCGGCGTATCAGTGATACTAATGCTGAAA
AGACTTTGATTCCCTATCTCAAAAGCAGAGGCATTGATAAGATTGACCAA
TTGGTTTTGACTCATACTGACACGGATCATATGGGAGATATGGAAGTGGT
GGCAAAGGCCTTTCATGTTGGGGAAGTTTTAGTTAGTCCAGGCAGTTTAA
CTAAGGCAAATTTTGTCAGTAAATTGAGAAGAATGAAAGTTAAGGTACAC
ATCACTAAGCCAGGGGAGACATTATCCATTATGGGGAGTCATTTACAGGT
ACTCTATCCGTTGAAAATAGGTGATGGTGGTAATAATGACTCTATCGTTC
TTTATGGACGTTTGCTAGGCTTAAATTTTCTCTTTACAGGAGATTTGGAA
AAAGAAGGAGAAGCAGAATTGCTAAAGACTTATCCCAATTTAAAAGTTGA
TGTCTTAAAAGCTGGACATCATGGTTCAAAAGGTTCTTCTTCACCTGAAT
TATTAGCTCAAATAGAGCCTAAAATTGCTCTTATCTCGGCAGGAAAGAAC
AATCGTTATAAACATCCCCATCAGGAGACACTGGACAGATTTGCGCAAAT
AAAAAGTCGGATTTATCGGACGGATCAAGAGGGTGCCATTCGTTTTAAGG
GTCTTAAGCATTGGCAGATTGAGACTGTGCGATAA

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