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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR343 IGR349 IGR348 IGR345 IGR340 IGR344 IGR350 IGR346 IGR342 IGR341 SMu0389 copZ, - SMu0387 SMu0384 rbfA, - SMu0383 SMu0393 SMu0392 SMu0388 cylB, - SMu0391 cylA, - SMu0390 nagA, - SMu0394 copA,ctpA, - SMu0386 SMu0389 copZ, - SMu0387 SMu0384 rbfA, - SMu0383 SMu0393 SMu0392 SMu0388 cylB, - SMu0391 cylA, - SMu0390 nagA, - SMu0394 copA,ctpA, - SMu0386 SMu0389 copZ, - SMu0387 SMu0384 rbfA, - SMu0383 SMu0392 SMu0388 cylB, - SMu0391 cylA, - SMu0390 nagA, - SMu0394 copA,ctpA, - SMu0386 copY, - SMu0385 copY, - SMu0385 SMu0393


LANL Gene ID: SMu0388

GenBank Locus Tag: SMU.428

DNA Molecule Name:
1  

GenBank ID:
24378920

Gene Name:


Definition:
conserved hypothetical protein, Cof family

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
400277

Gene Stop:
401104

Gene Length:
828

Molecular Weight*:
30335

pI*:
4.50

Net Charge*:
-12.41

EC:
 

Functional Class:
Unknown  

Gene Ontology:
Biological process
  GO:0006810    transport
  GO:0008152    metabolic process

Cellular component
  GO:0016020    membrane

Molecular function
  GO:0003824    catalytic activity
  GO:0005524    ATP binding
  GO:0015662    ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
  GO:0016787    hydrolase activity


Pathway: pathway table

Comment:


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Matches in gapped BLAST to conserved hypothetical proteins. Residues 3-273 are 52% similar to gi15675557 from S.pyogenes and 47% similar to gi15902868 from S.pneumoniae.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0388 (6e-72).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24378920|ref|NP_720875.1|  hypothetical protein SMU.428 [...   531   e-149
 gi|116627389|ref|YP_820008.1|  Predicted hydrolase of the HA...   276   7e-73
 gi|55820580|ref|YP_139022.1|  hypothetical protein stu0497 [...   276   8e-73
 gi|55822470|ref|YP_140911.1|  hypothetical protein str0497 [...   276   9e-73
 gi|77408758|ref|ZP_00785488.1|  hydrolase, haloacid dehaloge...   259   2e-67
 gi|50914788|ref|YP_060760.1|  Hydrolase (HAD superfamily) [S...   258   2e-67
 gi|22536571|ref|NP_687422.1|  hydrolase, haloacid dehalogena...   258   3e-67
 gi|19746608|ref|NP_607744.1|  hypothetical protein spyM18_17...   258   3e-67
 gi|15675557|ref|NP_269731.1|  hypothetical protein SPy_1700 ...   258   4e-67
 gi|21911016|ref|NP_665284.1|  hypothetical protein SpyM3_148...   257   4e-67


InterPro Summary:  InterProScan

InterPro
IPR000150
Family
Cof protein
TIGR00099 [6-268]T 1.8701566740059904E-66 TIGR00099 Cof-subfamily Cof-subfamily
PS01228 [6-17]T 8.0E-5 PS01228 COF_1 COF_1
PS01229 [222-244]T 8.0E-5 PS01229 COF_2 COF_2
InterPro
IPR001757
Family
ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
PR00119 [8-22]T 4.7E-5 PR00119 CATATPASE[222-241]T 4.7E-5 PR00119 CATATPASE[245-257]T 4.7E-5 PR00119 CATATPASE CATATPASE
InterPro
IPR006379
Family
HAD-superfamily hydrolase, subfamily IIB
TIGR01484 [6-241]T 1.6045563573741998E-24 TIGR01484 HAD-SF-IIB HAD-SF-IIB
InterPro
IPR013200
Domain
HAD superfamily hydrolase-like, type 3
PF08282 [7-268]T 7.49999605851358E-80 PF08282 Hydrolase_3 Hydrolase_3
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.1000 [3-272]T 8.000026593468089E-48 G3DSA:3.40.50.1000 G3DSA:3.40.50.1000 G3DSA:3.40.50.1000
PTHR10000 [191-253]T 3.7999986264479E-6 PTHR10000 PTHR10000 PTHR10000
SSF56784 [3-273]T 1.5E-63 SSF56784 SSF56784 SSF56784


COGS Summary:  COGS Search
BeTs to 12 clades of COG0561
COG name: Predicted hydrolases of the HAD superfamily
Functional Class: R
The phylogenetic pattern of COG0561 is a-tky-vCEBrH--GPOlin-
Number of proteins in this genome belonging to this COG is 11
Blocks Summary:  Blocks Search
***** IPB000150 (Cof protein) with a combined E-value of 4e-33.
    IPB000150A    3-17
    IPB000150B    37-46
    IPB000150C    220-252
***** IPB001757 (E1-E2 ATPases) with a combined E-value of 9.2e-06.
    IPB001757A    7-18
    IPB001757B    213-242


 ProDom Summary:  Protein Domain Search
No significant hits to the ProDom database.

Paralogs:  Local Blast Search
SMu0388 is paralogously related (blast p-value < 1e-3) to SMu0655, SMu0675, SMu1666, SMu0461, SMu1012, SMu0367, SMu0442, SMu0674, and SMu1072, all conserved hypotheticals, some with possible hydrolase function.


Pfam Summary:  Pfam Search
Residues 4 to 245 (E-value = 7.8e-09) place SMu0388 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)

 Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MIMVKLIAIDMDGTLLNSQKEIPQENIAVIQEAARSGYKIVLCTGRMQTG
VEPYFEQLGLVAEQEYAILNNGCSLHTINRDWQLLTYHDLNFNGVSYLYD
LLEGYPEIDLTLTADRDYLVLADQVSELVAYDASLVFTQAQTVGLNDVKH
AAKPVFQAMYLGESDRLDAFQQKFECKLAEKFTTVRSQPYIFEVMPQSIT
KATGLKELAQKLRISRTDIMAIGDALNDLEMLKAAGFSVAMGNASPEVKA
AADLVTGSNDDAGVAQAIAKYVLNK

Gene Nucleotide Sequence:  Sequence Viewer
ATGATTATGGTTAAACTGATTGCTATTGATATGGATGGCACGCTTTTGAA
TAGTCAAAAAGAAATCCCGCAAGAAAATATTGCTGTTATTCAAGAAGCAG
CTCGTTCGGGCTATAAAATTGTTCTTTGCACAGGCCGTATGCAGACTGGT
GTTGAGCCCTACTTTGAACAATTAGGTTTGGTTGCTGAACAAGAATATGC
GATTCTAAATAATGGCTGCTCTCTTCACACCATTAATAGAGATTGGCAGT
TACTGACTTATCATGATTTAAACTTTAATGGAGTATCTTATTTGTATGAT
TTGCTTGAGGGTTATCCTGAAATCGATTTAACATTGACTGCTGATAGGGA
TTATCTAGTTTTGGCTGATCAAGTATCAGAATTAGTAGCTTATGATGCGA
GTCTGGTATTTACGCAAGCACAGACTGTGGGCTTAAATGATGTAAAGCAT
GCTGCTAAACCAGTTTTTCAGGCTATGTATTTAGGAGAGAGCGATCGCTT
AGATGCTTTCCAGCAAAAATTTGAGTGCAAATTAGCAGAAAAATTTACTA
CTGTAAGAAGTCAGCCTTACATTTTTGAAGTGATGCCTCAAAGCATTACA
AAAGCTACTGGTTTGAAAGAATTAGCTCAGAAATTAAGAATTTCAAGGAC
TGATATTATGGCAATAGGAGATGCACTTAATGATCTTGAAATGCTCAAAG
CAGCAGGTTTCAGTGTGGCTATGGGAAATGCTAGTCCAGAAGTTAAGGCT
GCAGCAGACCTTGTGACTGGTTCTAATGATGATGCTGGTGTTGCTCAAGC
TATTGCCAAGTATGTCTTAAATAAGTGA

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