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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR212 IGR213 IGR211 IGR209 IGR210 IGR214 IGR208 SMu0237 gcl, - SMu0242 SMu0236 oppF, - SMu0235 arcC,aguC, - SMu0241 argF,arcB, - SMu0238 aguA, - SMu0240 aguD, - SMu0239 SMu0237 gcl, - SMu0242 SMu0236 oppF, - SMu0235 arcC,aguC, - SMu0241 argF,arcB, - SMu0238 aguA, - SMu0240 aguD, - SMu0239 Type: tandem, Name: SMu-TR-5 - 5 Type: tandem, Name: SMu-TR-5 - 5 SMu0237 gcl, - SMu0242 SMu0236 oppF, - SMu0235 arcC,aguC, - SMu0241 argF,arcB, - SMu0238 aguA, - SMu0240 aguD, - SMu0239


LANL Gene ID: SMu0239

GenBank Locus Tag: SMU.263

DNA Molecule Name:
1  

GenBank ID:
24378771

Gene Name:
aguD  

Definition:
amino acid permease /putrescine antiporter

Cellular Location:
Membrane, Cytoplasm, Extracellular [Evidence]

Gene Start:
253301

Gene Stop:
254659

Gene Length:
1359

Molecular Weight*:
49592

pI*:
9.90

Net Charge*:
6.38

EC:
 

Functional Class:
Transport and binding proteins; Amino acids, peptides, and amines  

Gene Ontology:
Biological process
  GO:0006810    transport
  GO:0006865    amino acid transport

Cellular component
  GO:0016020    membrane

Molecular function
  GO:0015171    amino acid transporter activity


Pathway: pathway table

Primary Evidence:
Griswold AR, Chen YY, Burne RA.
Analysis of an agmatine deiminase gene cluster in Streptococcus mutans UA159.
J Bacteriol. 2004 Mar;186(6):1902-4.
PMID: 14996823

Comment:


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Several hits in gapped BLAST to amino acid antiporters. Residues 3-431 are 58% similar to gi15673681 from L.lactis. Residues 1-430 are 46% similar to gi16802085 from L.monocytogenes.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2166 (1e-10).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24378771|ref|NP_720726.1|  putative amino acid antiporter...   716   0.0  
 gi|29375328|ref|NP_814482.1|  amino acid permease family pro...   664   0.0  
 gi|15673681|ref|NP_267855.1|  amino acid antiporter [Lactoco...   561   e-158
 gi|153164863|ref|ZP_01926038.1|  hypothetical protein LMHG_0...   473   e-132
 gi|153200426|ref|ZP_01942588.1|  hypothetical protein LMSG_0...   473   e-131
 gi|46906268|ref|YP_012657.1|  amino acid permease family pro...   472   e-131
 gi|16802085|ref|NP_463570.1|  hypothetical protein lmo0037 [...   472   e-131
 gi|47095105|ref|ZP_00232717.1|  amino acid permease family p...   470   e-130
 gi|47092162|ref|ZP_00229954.1|  amino acid permease family p...   450   e-124
 gi|116492001|ref|YP_803736.1|  Amino acid transporter [Pedio...   448   e-124


InterPro Summary:  InterProScan

InterPro
IPR002293
Family
Amino acid/polyamine transporter I
PTHR11785 [1-448]T 7.5e-48 PTHR11785 AMINO ACID TRANSPORTER AMINO ACID TRANSPORTER
InterPro
IPR004841
Domain
Amino acid permease-associated region
PF00324 [8-424]T 0.00036 PF00324 AA_permease AA_permease
noIPR
unintegrated
unintegrated
PIRSF006060 [1-452]T 1.2e-15 PIRSF006060 High-affinity amino acid transporter High-affinity amino acid transporter
PTHR11785:SF78 [1-448]T 7.5e-48 PTHR11785:SF78 GLUTAMATE/GAMMA-AMINOBUTYRATE ANTI-PORTER GLUTAMATE/GAMMA-AMINOBUTYRATE ANTI-PORTER
signalp [1-25]? NA signalp signal-peptide signal-peptide
tmhmm [9-31]? NA tmhmm transmembrane_regions[37-55]? NA tmhmm transmembrane_regions[84-104]? NA tmhmm transmembrane_regions[114-134]? NA tmhmm transmembrane_regions[149-169]? NA tmhmm transmembrane_regions[191-211]? NA tmhmm transmembrane_regions[226-246]? NA tmhmm transmembrane_regions[265-285]? NA tmhmm transmembrane_regions[323-343]? NA tmhmm transmembrane_regions[349-369]? NA tmhmm transmembrane_regions[397-419]? NA tmhmm transmembrane_regions[425-447]? NA tmhmm transmembrane_regions transmembrane_regions


COGS Summary:  COGS Search
BeTs to 10 clades of COG0531
COG name: Amino acid transporters
Functional Class: E
The phylogenetic pattern of COG0531 is AMt-Y--cEBRh--GP--INX
Number of proteins in this genome belonging to this COG is 3
Blocks Summary:  Blocks Search
***** IPB002027 (Amino acid permease) with a combined E-value of 4.1e-13.
    IPB002027C    199-237
    IPB002027D    283-322


 ProDom Summary:  Protein Domain Search
Residues 256-431 are 58% similar to a (PROTEOME AMINO COMPLETE ACID) protein domain (PD400363 which is seen in Q9CEY5_LACLA.

Residues 66-154 are 30% similar to a (ACID AMINO PROTEOME COMPLETE) protein domain (PD000214 which is seen in Q9HV05_PSEAE.

Residues 3-178 are 52% similar to a (PROTEOME AMINO COMPLETE ACID) protein domain (PD399919 which is seen in Q9CEY5_LACLA.

Residues 193-255 are 84% similar to a (TRANSPORT AMINO ACID AMINO-ACID PERMEASE TRANSMEMBRANE) protein domain (PD000442 which is seen in Q9CEY5_LACLA.


Paralogs:  Local Blast Search
SMu0239 is paralogously related (blast p-value < 1e-3) to SMu1320, SMu0014, and SMu0863, predicted amino acid permeases.


Pfam Summary:  Pfam Search
Residues 7 to 451 (E-value = 9.2e-05) place SMu0239 in the AA_permease family which is described as Amino acid permease (PF00324)

 Structural Feature(s):
Feature Type  Start  Stop
cleavable  
1  
25
transmembrane  
38  
54
transmembrane  
94  
110
transmembrane  
118  
134
transmembrane  
149  
165
transmembrane  
194  
210
transmembrane  
225  
241
transmembrane  
274  
290
transmembrane  
324  
340
transmembrane  
353  
369
transmembrane  
397  
413
transmembrane  
431  
447

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MEGKKKFSLFSAVLSVICVVFVAEAAAPVAAIGNSQFFWWLFLLIAFLLP
YGLISSELGTTYIGDGGIYDWVTKAFGHKWGSRVAWYYWINFPLWLASLA
VMTPGLLTTVTGHNFSTVTAIIVELIFIWLVIWISFYPVSDSIWILNGAA
VIKMLLALLVGGLGLYVALTKGMANEMTLKSLLPSFNLNSLSYISVIIFN
LLGFEVICTFAGDMENPKKQIPQSIIVAGLVIAAIYIFSAFGIGVSIPTD
KISTSSGMMDSFKLLTGSTGGWFIMTMAFLFLLTLFGNMISWSLGVNNTA
SYAAENGDMPQFFAKRSRKRDMPIGAALANGIVASIVVVIAPFLPNQDLF
WAFFSLNLVMFLLSYVPVFPAFFKLRKIDPDTPRPFKVSGNDSFLRLLVI
LPMILIIISLIFTALPLAFDSETLASKLPITIGSLIFIGIGELIIIIKKI
KK

Gene Nucleotide Sequence:  Sequence Viewer
ATGGAAGGAAAGAAAAAATTTAGTTTATTTAGTGCAGTACTTTCTGTTAT
TTGTGTCGTCTTTGTTGCTGAAGCGGCTGCTCCGGTAGCTGCTATTGGGA
ATTCTCAATTCTTTTGGTGGCTCTTTTTATTAATTGCCTTTCTTCTACCT
TATGGTTTGATTTCATCTGAATTGGGAACAACTTATATTGGTGATGGTGG
TATCTATGATTGGGTGACCAAGGCTTTTGGTCATAAATGGGGCTCTCGAG
TGGCTTGGTATTATTGGATTAATTTTCCACTCTGGCTAGCTTCTCTGGCA
GTTATGACACCGGGTTTATTAACAACAGTTACTGGACACAACTTTTCAAC
TGTTACAGCTATTATTGTTGAACTCATTTTTATTTGGCTGGTTATTTGGA
TTAGTTTTTATCCCGTGAGTGATAGTATTTGGATTTTAAATGGTGCAGCT
GTCATTAAAATGTTATTGGCCTTACTTGTTGGTGGCTTGGGCCTTTATGT
GGCCCTGACCAAGGGCATGGCAAATGAAATGACCTTAAAGTCACTGTTGC
CTTCTTTTAATCTGAACAGTCTCTCTTATATTTCAGTTATTATTTTTAAC
CTGCTCGGTTTTGAGGTTATTTGTACTTTTGCAGGAGATATGGAAAATCC
TAAAAAGCAAATTCCTCAATCTATTATTGTTGCAGGTCTGGTAATTGCAG
CTATCTATATTTTTTCTGCTTTTGGTATTGGCGTCTCAATTCCAACGGAT
AAGATTTCAACCAGCAGTGGTATGATGGATAGTTTTAAATTATTAACAGG
CTCAACGGGCGGTTGGTTTATCATGACCATGGCTTTTCTATTTTTATTGA
CCTTGTTTGGCAATATGATTTCTTGGTCTCTCGGTGTTAATAATACAGCT
TCTTATGCTGCAGAAAATGGAGACATGCCCCAATTTTTTGCTAAAAGAAG
TCGCAAAAGAGATATGCCAATTGGTGCTGCTCTTGCTAATGGTATTGTTG
CTAGCATTGTGGTTGTTATTGCCCCATTTTTGCCCAATCAAGATTTATTC
TGGGCTTTCTTCTCCTTAAACTTAGTCATGTTTTTATTGTCTTATGTTCC
TGTATTTCCAGCATTTTTCAAGTTGAGAAAAATAGATCCGGATACACCGC
GTCCTTTTAAGGTTAGTGGCAATGATAGTTTTTTGAGATTACTTGTTATT
TTACCAATGATTTTAATTATCATTTCCTTGATTTTTACTGCTCTACCACT
GGCTTTTGATTCTGAAACTTTAGCTTCAAAATTACCAATAACAATTGGTT
CTCTTATTTTTATAGGGATAGGTGAACTTATTATTATCATCAAAAAAATA
AAGAAATGA

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