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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap IGR146 IGR140 IGR142 IGR141 IGR139 IGR144 IGR145 SMu0156 SMu0157 SMu0158 SMu0161 sloB, - SMu0165 fimA,lraI, - SMu0166 mvaK,mvk, - SMu0163 SMu0159 SMu0162 SMu0156 SMu0157 SMu0158 SMu0161 sloB, - SMu0165 fimA,lraI, - SMu0166 mvaK,mvk, - SMu0163 SMu0159 SMu0162 SMu0156 SMu0158 SMu0161 sloB, - SMu0165 fimA,lraI, - SMu0166 mvaK,mvk, - SMu0163 SMu0159 SMu0162 sloA, - SMu0164 SMu0160 sloA, - SMu0164 SMu0160 SMu0157


LANL Gene ID: SMu0162

GenBank Locus Tag: SMU.180

DNA Molecule Name:
1  

GenBank ID:
24378694

Gene Name:


Definition:
oxidoreductase, possible fumarate reductase

Cellular Location:
Cytoplasm, Extracellular [Evidence]

Gene Start:
176037

Gene Stop:
178448

Gene Length:
2412

Molecular Weight*:
86803

pI*:
4.90

Net Charge*:
-25.26

EC:
 

Functional Class:
Unassigned  

Gene Ontology:
Biological process
  GO:0006118    electron transport

Cellular component
  GO:0016020    membrane

Molecular function
  GO:0000104    succinate dehydrogenase activity
  GO:0010181    FMN binding
  GO:0016491    oxidoreductase activity


Pathway: pathway table

Comment:


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
Mixed similarities to oxidoreductases, conserved hypotheticals and Chain A, flavocytochrome C3 sequences. Residues 1-191 are 54% similar to 15901322, a predicted oxidoreductase in S.pyogenes and also 54% similar to 15903369, an unknown from S.pneumoniae.





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1083 (7e-61).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24378694|ref|NP_720649.1|  putative oxidoreductase; possi...  1581   0.0  
 gi|150016926|ref|YP_001309180.1|  flavocytochrome c [Clostri...  1088   0.0  
 gi|28378151|ref|NP_785043.1|  fumarate reductase, flavoprote...  1058   0.0  
 gi|116628730|ref|YP_813902.1|  Fumarate reductase flavoprote...   784   0.0  
 gi|42518137|ref|NP_964067.1|  hypothetical protein LJ0051 [L...   771   0.0  
 gi|57865762|ref|YP_189929.1|  NADH:flavin oxidoreductase/fum...   743   0.0  
 gi|27467113|ref|NP_763750.1|  putative NADH-dependent flavin...   741   0.0  
 gi|156976764|ref|YP_001447670.1|  hypothetical protein VIBHA...   706   0.0  
 gi|149187371|ref|ZP_01865669.1|  NADH:flavin oxidoreductase/...   665   0.0  
 gi|89074803|ref|ZP_01161257.1|  NADH:flavin oxidoreductase/f...   644   0.0


InterPro Summary:  InterProScan

InterPro
IPR000759
Family
Adrenodoxin reductase
PR00419 [302-324]T 3.8E-5 PR00419 ADXRDTASE[325-338]T 3.8E-5 PR00419 ADXRDTASE ADXRDTASE
InterPro
IPR001613
Family
Flavin-containing amine oxidase
PR00757 [302-321]T 9.0E-5 PR00757 AMINEOXDASEF[765-782]T 9.0E-5 PR00757 AMINEOXDASEF AMINEOXDASEF
InterPro
IPR003953
Domain
Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal
PF00890 [302-784]T 9.90001804798338E-63 PF00890 FAD_binding_2 FAD_binding_2
InterPro
IPR005025
Domain
NADPH-dependent FMN reductase
PF03358 [1-167]T 1.09999909120792E-13 PF03358 FMN_red FMN_red
InterPro
IPR007329
Domain
FMN-binding
PF04205 [201-275]T 7.499996058513579E-20 PF04205 FMN_bind FMN_bind
InterPro
IPR010960
Family
Flavocytochrome c
TIGR01813 [302-796]T 4.68089143677334E-99 TIGR01813 flavo_cyto_c flavo_cyto_c
noIPR
unintegrated
unintegrated
G3DSA:3.40.50.360 [1-187]T 6.100026561498099E-50 G3DSA:3.40.50.360 G3DSA:3.40.50.360 G3DSA:3.40.50.360
G3DSA:3.50.50.60 [296-800]T 6.00001679190146E-71 G3DSA:3.50.50.60 G3DSA:3.50.50.60 G3DSA:3.50.50.60
PTHR11632 [301-390]T 6.89998448199267E-53 PTHR11632 PTHR11632[433-542]T 6.89998448199267E-53 PTHR11632 PTHR11632[559-662]T 6.89998448199267E-53 PTHR11632 PTHR11632[705-798]T 6.89998448199267E-53 PTHR11632 PTHR11632 PTHR11632
PTHR11632:SF3 [301-390]T 6.89998448199267E-53 PTHR11632:SF3 PTHR11632:SF3[433-542]T 6.89998448199267E-53 PTHR11632:SF3 PTHR11632:SF3[559-662]T 6.89998448199267E-53 PTHR11632:SF3 PTHR11632:SF3[705-798]T 6.89998448199267E-53 PTHR11632:SF3 PTHR11632:SF3 PTHR11632:SF3
SSF51905 [280-800]T 2.3000000000000003E-52 SSF51905 SSF51905 SSF51905
SSF52218 [1-173]T 5.200000000000001E-35 SSF52218 SSF52218 SSF52218
SSF56425 [590-740]T 8.2E-39 SSF56425 SSF56425 SSF56425


COGS Summary:  COGS Search
BeTs to 10 clades of COG1053
COG name: Succinate dehydrogenase/fumarate reductase, flavoprotein subunits
Functional Class: C
The phylogenetic pattern of COG1053 is Amt-YqvcEbRhuj----inx
Number of proteins in this genome belonging to this COG is 2
Blocks Summary:  Blocks Search
***** IPB003952 (Fumarate reductase / succinate dehydrogenase FAD-binding site) with a combined E-value of 8.4e-17.
    IPB003952A    302-316
    IPB003952F    571-621
    IPB003952H    761-792
***** IPB000447 (FAD-dependent glycerol-3-phosphate dehydrogenase) with a combined E-value of 9.5e-09.
    IPB000447A    301-353
    IPB000447C    523-545
***** IPB000171 (Bacterial-type phytoene dehydrogenase) with a combined E-value of 2.8e-08.
    IPB000171A    304-334
***** PR00368 (FAD-dependent pyridine nucleotide reductase signature) with a combined E-value of 6.4e-08.
    PR00368A    302-324
    PR00368E    763-770
***** IPB000103 (Pyridine nucleotide-disulphide oxidoreductase class-II) with a combined E-value of 5.5e-06.
    IPB000103A    302-322
    IPB000103A    303-323
    IPB000103C    268-316
***** PR00420 (Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature) with a combined E-value of 6.3e-06.
    PR00420A    302-324
    PR00420D    537-553


 ProDom Summary:  Protein Domain Search
Residues 735-798 are 37% similar to a (FLAVOPROTEIN SUBUNIT OXIDOREDUCTASE FAD DEHYDROGENASE) protein domain (PD001219 which is seen in Q9CGH2_LACLA.

Residues 2-131 are 49% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE NADPH PHOSPHODIESTERASE) protein domain (PD009603 which is seen in Q9CIJ0_LACLA.

Residues 480-798 are 25% similar to a (PLASMID) protein domain (PD139700 which is seen in Q9L5J6_SALTI.

Residues 675-730 are 39% similar to a (FLAVOPROTEIN SUBUNIT REDUCTASE FUMARATE) protein domain (PD129803 which is seen in FRD2_SHEFR.

Residues 462-628 are 30% similar to a (OXIDOREDUCTASE 1-DEHYDROGENASE FAD) protein domain (PD008718 which is seen in P71864_MYCTU.

Residues 488-735 are 26% similar to a (C SUBUNIT FLAVOCYTOCHROME FLAVIN) protein domain (PD062665 which is seen in P96182_WOLSU.

Residues 681-790 are 36% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE) protein domain (PD009971 which is seen in Q9I1M6_PSEAE.


Paralogs:  Local Blast Search
SMu0162 is paralogously related (blast p-value < 1e-3) to SMu0998, SMu1282, SMu0997, SMu0161, SMu1286, SMu0112, SMu0116, and SMu0331, all conserved hypotheticals or possible reductases.


Pfam Summary:  Pfam Search
Residues 1 to 167 (E-value = 9.3e-16) place SMu0162 in the FMN_red family which is described as NADPH-dependent FMN reductase (PF03358)
Residues 195 to 275 (E-value = 4.3e-22) place SMu0162 in the FMN_bind family which is described as FMN-binding domain (PF04205)
Residues 471 to 801 (E-value = 2.2e-14) place SMu0162 in the FAD_binding_2 family which is described as FAD binding domain (PF00890)

 Structural Feature(s):
Feature Type  Start  Stop
transmembrane  
303  
319

Top PDB Hits:
pdb|1E39|A Chain A, Flavocytochrome C3 From Shewanella Frigidim... 209 1e-054
pdb|1QJD|A Chain A, Flavocytochrome C3 From Shewanella Frigidim... 208 2e-054
pdb|1D4C|A Chain A, Crystal Structure Of The Uncomplexed Form O... 206 6e-054

Gene Protein Sequence:
MKLIAIVGTNAKQSYNRILLQFMKRHFVQKADIDIMEIANVPMFNETEDQ
TDLPAIQNFNTKISQADGVIIATPEHNHTIPSSLNSLLEWLSFKVHPLDG
KPLMIVGASYDVQGSSRAQLHLRQILDAPGVNAAVMPGSEFLLGRAHQAF
DEAGNLKSEATVDFLESCFFKFLRFVQVANQLNEPEEVSFEAGTYQVTTQ
GHNGKLPMTVTLSEEKIEKIDIDSSGESSGIADIVFTRIPNEILEGQTLN
VDAVSGASVTSNGVLDGVARAIKLAGGNPDVLRKRPKAPSALDKEDKTYS
TDVVIVGGGGAGLAAAARVLQAGKQVMVLEKFPALGGNTVRSGGLLNAAD
PEWQKTFPANPGEAHNLSELIQTDEDSIAAEYLADFKELKQQVTNYLKDP
SYLFDSNILHRIQTYIGGKRTDRNGCEVYGNYDLVKVLTDKDLDSVHWLA
DIGVDFDRSEVSMPVGALWRRSHKPKQPMGYAFIEALDTYIRKNSGTILT
DTAVTDFILENGLIKGVLAKGRNGQTITVHAQAVVLASGGFGANTKMLQQ
YNTYWSNIDDNIQTTNSPAITGDGIRLGQSIGAALVGMGFSQMMPVSDPN
TGAIFSGLQVPPANFVMVNQEGKRFVDEYGSRDTLSKAAIDNGGLFYLIA
DENIKATAMNTSNEKIEEQVAAGTLYRADTLESLAEQIGVDPATLVETIN
NYNSYVEAGYDPEFDKGAFDLKVEKAPFYATPRKPATHHTMGGLKIDTQA
HVIKEDGNKIPSLYAAGEVTGGIHAGNRLGGNALADIFTFGRIAAETAVT
ECC

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAATTAATTGCTATTGTTGGGACCAATGCTAAGCAATCCTATAACCG
AATTTTACTGCAATTCATGAAGAGGCATTTTGTTCAAAAGGCTGATATTG
ACATCATGGAAATTGCTAATGTTCCAATGTTCAATGAAACAGAGGATCAA
ACGGATTTACCTGCTATCCAAAACTTTAACACTAAAATCAGCCAAGCTGA
TGGAGTCATTATTGCAACGCCCGAGCACAACCACACCATTCCATCAAGTC
TAAACAGCCTTTTGGAATGGCTGTCCTTTAAAGTGCATCCCCTAGATGGC
AAACCCCTTATGATCGTTGGGGCTTCTTATGATGTGCAAGGATCTTCTCG
AGCGCAATTGCACTTACGGCAGATTTTAGATGCTCCGGGTGTCAATGCGG
CCGTCATGCCGGGCAGTGAATTTTTACTGGGACGCGCTCATCAGGCTTTC
GACGAAGCAGGCAACCTCAAGTCAGAAGCAACGGTTGATTTTCTAGAGTC
TTGCTTCTTTAAATTTTTACGGTTTGTGCAAGTGGCTAATCAATTGAATG
AACCAGAAGAAGTAAGCTTTGAAGCAGGGACTTATCAGGTGACAACCCAA
GGGCATAATGGCAAATTGCCAATGACTGTAACCTTATCAGAAGAGAAGAT
TGAAAAGATTGATATTGATAGTTCCGGAGAATCCTCAGGAATAGCCGATA
TTGTCTTTACACGGATCCCAAATGAAATATTGGAAGGTCAGACTTTGAAT
GTAGATGCTGTGTCAGGGGCATCGGTGACCAGCAATGGTGTTCTGGACGG
GGTTGCCAGAGCAATTAAGCTGGCAGGAGGCAATCCGGATGTTTTGCGGA
AACGTCCAAAGGCACCATCAGCCTTGGATAAAGAAGATAAGACTTACAGC
ACAGATGTGGTTATCGTAGGTGGAGGTGGGGCTGGTTTAGCAGCCGCTGC
TCGAGTGCTGCAAGCAGGTAAGCAAGTGATGGTGCTTGAAAAGTTCCCTG
CTCTTGGAGGTAATACTGTACGTTCTGGTGGCTTATTAAATGCAGCAGAC
CCTGAATGGCAAAAGACTTTTCCCGCTAATCCCGGGGAGGCTCATAATCT
TTCCGAGCTGATTCAAACAGATGAAGACAGTATTGCAGCAGAATATTTAG
CCGACTTTAAGGAATTAAAGCAGCAAGTAACTAATTACTTGAAAGATCCA
AGCTATTTATTTGATTCTAATATTCTCCATCGGATTCAAACCTATATTGG
TGGTAAAAGAACTGATCGTAATGGTTGTGAAGTCTATGGCAATTATGATC
TTGTAAAGGTGTTAACAGATAAGGATCTTGATTCCGTCCATTGGTTAGCG
GATATTGGTGTTGATTTTGATCGCTCTGAAGTTAGTATGCCAGTAGGAGC
TTTATGGCGTCGCTCTCACAAACCTAAACAACCGATGGGTTATGCTTTTA
TTGAAGCTTTGGATACCTATATTCGCAAGAATAGTGGTACTATTTTAACG
GATACTGCAGTCACAGATTTTATTTTAGAAAATGGTCTTATTAAAGGAGT
ACTTGCTAAAGGCCGCAATGGACAAACCATTACCGTCCATGCCCAAGCTG
TTGTCTTGGCTTCTGGTGGTTTTGGTGCCAATACTAAGATGTTACAACAA
TATAATACTTATTGGAGTAATATTGATGATAACATTCAAACAACGAATTC
ACCAGCTATAACAGGTGATGGCATTCGCTTAGGGCAAAGTATTGGTGCCG
CTCTTGTTGGTATGGGCTTTAGCCAAATGATGCCAGTGTCAGACCCGAAT
ACGGGAGCCATTTTCTCAGGCTTACAAGTTCCGCCGGCAAACTTTGTTAT
GGTTAATCAAGAAGGCAAACGTTTTGTGGATGAATATGGTAGCCGTGATA
CGCTTTCTAAAGCTGCGATTGATAATGGTGGTCTCTTCTATCTAATTGCT
GATGAAAATATCAAAGCAACTGCCATGAATACCAGCAATGAAAAAATTGA
AGAACAAGTTGCAGCAGGAACGCTTTATCGTGCTGATACTTTAGAAAGTT
TGGCAGAGCAAATTGGTGTGGATCCCGCTACCCTTGTGGAAACCATCAAC
AATTACAATTCCTATGTTGAAGCGGGCTATGATCCTGAGTTTGATAAAGG
AGCTTTTGATCTCAAGGTTGAAAAGGCGCCATTTTATGCAACACCTCGAA
AACCAGCAACCCATCATACGATGGGCGGTTTGAAGATTGATACACAAGCT
CATGTTATTAAAGAAGATGGCAATAAGATTCCATCTCTTTACGCTGCTGG
GGAAGTGACAGGCGGCATTCACGCAGGCAATCGCTTAGGCGGTAATGCTT
TAGCTGATATCTTTACTTTTGGACGTATTGCAGCAGAAACAGCTGTAACA
GAATGCTGCTAA

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