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Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap tRNA-Thr-2 IGR80 IGR87 IGR86 IGR83 IGR88 IGR84 tpn, - SMu0095 SMu0100 SMu0099 SMu0097 SMu0096 sorD, - SMu0089 sorB, - SMu0091 scrR,lacI, - SMu0094 SMu0098 yicI, - SMu0093 tpn, - SMu0095 SMu0100 SMu0099 SMu0097 SMu0096 sorD, - SMu0089 sorB, - SMu0091 scrR,lacI, - SMu0094 SMu0098 yicI, - SMu0093 tpn, - SMu0095 SMu0099 SMu0100 SMu0096 sorB, - SMu0091 scrR,lacI, - SMu0094 SMu0098 yicI, - SMu0093 sorA, - SMu0092 sorC, - SMu0090 sorA, - SMu0092 sorC, - SMu0090 sorD, - SMu0089 SMu0097


LANL Gene ID: SMu0094

GenBank Locus Tag: SMU.105

DNA Molecule Name:
1  

Genomic Island ID:
4

GenBank ID:
24378626

 Gene Name:
scrR  lacI  

 Definition:
SCR operon transcriptional repressor

 Cellular Location:
Cytoplasm [Evidence]

 Gene Start:
106501

Gene Stop:
107499

Gene Length:
999

Molecular Weight*:
37572

pI*:
7.20

Net Charge*:
0.47

EC:
 

 Functional Class:
Regulatory functions; General regulatory  

 Gene Ontology:
Biological process
  GO:0006355    regulation of transcription, DNA-dependent

Cellular component
  GO:0005622    intracellular

Molecular function
  GO:0003700    transcription factor activity


 Pathway: pathway table

 Primary Evidence:
Hiratsuka,K., Wang,B., Sato,Y. and Kuramitsu,H.
Regulation of sucrose-6-phosphate hydrolase activity in
Streptococcus mutans: characterization of the scrR gene
Infect. Immun. 66 (8), 3736-3743 (1998)
PubMed: 98339875

Simpson,C.L. and Russell,R.R.
Identification of a homolog of CcpA catabolite repressor protein in Streptococcus mutans
Infect. Immun. 66 (5), 2085-2092 (1998)
PubMed: 98234037


 Secondary Evidence:
Bell CE, Lewis M.
Crystallographic analysis of Lac repressor bound to natural operator O1.
J Mol Biol. 2001 Oct 5;312(5):921-6.
PMID: 11580238

Comment:
For other 'lac' genes see SMu0104 (lacD); SMu0793 (lacR); SMu0794 (lacC); SMu1359 (lacC); SMu1354 (lacX);SMu1355 (lacG); SMu1356 (lacE); SMu1357 (lacF);SMu1358 (lacD);SMu1360 (lacB); SMu1361 (lacA);SMu1362 (lacR) and SMu1451 (lacE).

For other 'scr' genes see SMu1676 (scrK); SMu1677 (scrA); SMu1678 (scrB) and SMu1679 (scrR).



 View in HOMD Genome Viewer

 Blast Summary:  PSI-Blast Search
This sequence corresponds to the previously published 1184967 and 2495406 in GenBank. See also 2155300, 2323342,
2495405.

Similarities in gapped BLAST to sucrose operon regulatory protein, e.g. residues 2-313 are 33% similar to 15903663 of S.pneumoniae. Residues 2-327 are 30% similar to the LacI family sequence of S.pneumoniae (15901628).





The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1692 (2e-30).


 Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24378626|ref|NP_720581.1|  putative transcriptional regul...   636   0.0  
 gi|157074898|gb|ABV09581.1|  transcriptional repressor MsmR ...   180   1e-43
 gi|58336830|ref|YP_193415.1|  msm operon repressor [Lactobac...   179   2e-43
 gi|15903663|ref|NP_359213.1|  Sucrose operon repressor (SCR ...   171   5e-41
 gi|116515545|ref|YP_817038.1|  sugar-binding transcriptional...   171   6e-41
 gi|146318995|ref|YP_001198707.1|  Transcriptional regulator ...   167   1e-39
 gi|90962680|ref|YP_536596.1|  Transcriptional regulator, Lac...   166   3e-39
 gi|116629183|ref|YP_814355.1|  Transcriptional regulator [La...   165   3e-39
 gi|42518666|ref|NP_964596.1|  hypothetical protein LJ0744 [L...   162   2e-38
 gi|111657709|ref|ZP_01408435.1|  hypothetical protein SpneT_...   158   5e-37


InterPro Summary:  InterProScan

InterPro
IPR000843
Domain
Bacterial regulatory protein, LacI
PR00036 [6-16]T 2.9E-5 PR00036 HTHLACI[16-26]T 2.9E-5 PR00036 HTHLACI HTHLACI
PF00356 [5-27]T 7.7000017138774E-4 PF00356 LacI LacI
SM00354 [4-73]T 3.1000000000001995E-17 SM00354 HTH_LACI HTH_LACI
PS00356 [7-25]T 8.0E-5 PS00356 HTH_LACI_1 HTH_LACI_1
PS50932 [5-58]T 0.0 PS50932 HTH_LACI_2 HTH_LACI_2
InterPro
IPR001761
Domain
Periplasmic binding protein/LacI transcriptional regulator
PF00532 [61-199]T 6.09999977126217E-4 PF00532 Peripla_BP_1 Peripla_BP_1
InterPro
IPR010982
Domain
Lambda repressor-like, DNA-binding
SSF47413 [5-59]T 1.4E-14 SSF47413 Lambda_like_DNA Lambda_like_DNA
noIPR
unintegrated
unintegrated
G3DSA:1.10.260.40 [5-61]T 4.3000017064587894E-12 G3DSA:1.10.260.40 G3DSA:1.10.260.40 G3DSA:1.10.260.40
G3DSA:3.40.50.2300 [62-197]T 6.6999968762595706E-21 G3DSA:3.40.50.2300 G3DSA:3.40.50.2300 G3DSA:3.40.50.2300
SSF53822 [60-325]T 3.0999999999999997E-46 SSF53822 SSF53822 SSF53822


COGS Summary:  COGS Search
BeTs to 3 clades of COG1609
COG name: Transcriptional regulators of the LacI family
Functional Class: K
The phylogenetic pattern of COG1609 is ------V-EBrH---------
Number of proteins in this genome belonging to this COG is 5
Blocks Summary:  Blocks Search
***** IPB000843 (Bacterial regulatory protein, LacI family) with a combined E-value of 1.9e-23.
    IPB000843A    6-26
    IPB000843B    30-68


 ProDom Summary:  Protein Domain Search
Residues 66-122 are 40% similar to a (TRANSCRIPTION REGULATION DNA-BINDING REPRESSOR) protein domain (PD353269 which is seen in SCRR_STRMU.

Residues 141-277 are 27% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD000591 which is seen in SACR_LACLA.

Residues 6-79 are 42% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD000947 which is seen in CCPA_BACSU.

Residues 5-122 are 32% similar to a (TRANSCRIPTION REPRESSOR REGULATION) protein domain (PD023303 which is seen in O07567_BACSU.


Paralogs:  Local Blast Search
SMu0094 is paralogously related (blast p-value < 1e-3) to SMu1679, SMu1446, SMu1424, and SMu0807, lacI family and related sugar operon repressors.


Pfam Summary:  Pfam Search
Residues 5 to 30 (E-value = 4.8e-05) place SMu0094 in the LacI family which is described as Bacterial regulatory proteins, lacI family (PF00356)

 Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MKRNPTINDVAQLANVSRGTVSNYINGITIREENKAKIEKAIAELKYVPN
ARARELKTSKTSTVVLIVPTTWSPFFAELVYRMQVELDRIGFKMILANSH
ADPDEEEEILRMASLNQVTGVITMSYSNIYNFINIGKKLNLVSIERFISE
DVPLITSDNYGGGQLAAEKLITFGSKRFLLLRRKTNHYNATDKRTEGFLH
IMKENNLPVDIFEASLKENYIEEFIHYLKTHFSGDVLTFDGIFGVTDEYA
VIAKQVLFELNPSYLNKVNIIGFDGSKSQEKGSYQIASIRQPVEAMVKAA
VKVLKKLIDGEEVPSHYSKVFDVSFVEPERLV

Gene Nucleotide Sequence:  Sequence Viewer
ATGAAAAGAAATCCTACAATCAATGATGTAGCTCAACTGGCTAATGTCAG
TCGAGGAACTGTATCAAACTATATCAATGGTATTACTATTCGAGAAGAGA
ACAAGGCTAAAATTGAAAAAGCAATTGCAGAGTTGAAATATGTTCCCAAT
GCTAGAGCTCGGGAGTTAAAAACATCAAAAACATCGACTGTTGTGCTAAT
TGTACCAACGACGTGGAGTCCTTTTTTTGCAGAGTTGGTTTATAGAATGC
AAGTTGAATTGGATCGAATTGGTTTTAAAATGATATTGGCCAATTCTCAT
GCAGATCCTGATGAAGAAGAAGAAATTCTTCGCATGGCATCCTTGAATCA
GGTTACAGGTGTGATTACGATGTCCTATTCCAATATTTATAATTTCATAA
ATATTGGGAAGAAATTAAATTTGGTTTCCATTGAACGTTTTATTTCAGAA
GATGTCCCTCTTATTACCAGTGATAATTATGGTGGAGGTCAATTAGCTGC
TGAGAAATTGATCACATTTGGTTCAAAACGGTTCTTACTTTTGAGAAGAA
AAACAAATCATTATAATGCGACTGATAAACGGACAGAAGGTTTTTTACAT
ATTATGAAAGAAAATAATCTTCCTGTTGACATTTTTGAGGCTTCTTTAAA
AGAGAATTATATTGAAGAATTTATCCATTATTTGAAAACTCATTTTTCTG
GAGATGTCTTAACTTTTGATGGCATATTTGGTGTAACTGATGAATATGCT
GTCATTGCTAAACAAGTGCTTTTTGAGCTAAATCCCTCTTATTTAAACAA
AGTGAACATTATAGGGTTTGATGGCTCAAAGTCGCAAGAAAAAGGCAGTT
ATCAAATTGCTTCCATTAGGCAGCCAGTGGAAGCAATGGTGAAGGCAGCT
GTCAAAGTTTTAAAAAAGTTAATTGATGGCGAGGAGGTTCCAAGTCATTA
TAGTAAGGTATTTGATGTTAGTTTTGTTGAGCCTGAAAGGTTAGTGTAA

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