Basic Search | Intermediate Search | Gene Image Map |  Home

Streptococcus mutans Search Results

Record: 1 of 1  
MiniMap tRNA-Gly-2 tRNA-Gly-1 tRNA-Val-1 tRNA-Thr-1 tRNA-Asp-1 tRNA-Phe-1 tRNA-Ile-1 tRNA-Met-1 tRNA-Met-2 tRNA-Met-3 tRNA-Pro-1 tRNA-Arg-1 tRNA-Lys-1 tRNA-Leu-1 tRNA-Leu-2 tRNA-Ser-2 tRNA-Ser-1 rRNA-5S-1 rRNA-23S-1 IGR17 IGR15 IGR16 IGR18 IGR13 mreD,rodB, - SMu0017 mreC, - SMu0016 prsA,kprS, - SMu0019 plsX,ylpD, - SMu0022 aspC, - SMu0020 gbpB,pcsB,sagA, - SMu0018 mreD,rodB, - SMu0017 mreC, - SMu0016 prsA,kprS, - SMu0019 plsX,ylpD, - SMu0022 aspC, - SMu0020 gbpB,pcsB,sagA, - SMu0018 Type: tandem, Name: SMu-TR-1 - 1 Type: tandem, Name: SMu-TR-1 - 1 mreD,rodB, - SMu0017 mreC, - SMu0016 prsA,kprS, - SMu0019 aspC, - SMu0020 gbpB,pcsB,sagA, - SMu0018 recO, - SMu0021 recO, - SMu0021 plsX,ylpD, - SMu0022


LANL Gene ID: SMu0017

GenBank Locus Tag: SMU.21

DNA Molecule Name:
1  

GenBank ID:
24378549

Gene Name:
mreD  rodB  

Definition:
cell shape-determining protein MreD

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
24466

Gene Stop:
24972

Gene Length:
507

Molecular Weight*:
19790

pI*:
9.70

Net Charge*:
3.65

EC:
2.4.1.13  

Functional Class:
Cell envelope; Biosynthesis and degradation of murein sacculus and peptidoglycan  

Gene Ontology:

Pathway: pathway table
Starch and sucrose metabolism

Primary Evidence:
Chia,J.S., Lee,Y.Y., Huang,P.T. and Chen,J.Y.
Identification of Stress-Responsive Genes in Streptococcus mutans
by Differential Display Reverse Transcription-PCR
Infect. Immun. 69 (4), 2493-2501 (2001)
PubMed: 11254612

Chia,J.S., Chang,L.Y., Shun,C.T., Chang,Y.Y. and Chen,J.Y
A 60-Kilodalton Immunodominant Glycoprotein Is Essential for Cell
Wall Integrity and the Maintenance of Cell Shape in Streptococcus
mutans
Infect. Immun. 69 (11), 6987-6998 (2001)
PubMed: 11598074


Secondary Evidence:
Kubo,M., Pierro,D.J., Mochizuki,Y., Kojima,T., Yamazaki,T.,
Satoh,S., Takizawa,N. and Kiyohara,H.
Bacillus stearothermophilus cell shape determinant gene, mreC and
mreD, and their stimulation of protease production in Bacillus
subtilis
Biosci. Biotechnol. Biochem. 60 (2), 271-276 (1996)
PubMed: 9063975.

Burger A, Sichler K, Kelemen G, Buttner M, Wohlleben W.
Identification and characterization of the mre gene region of Streptomyces coelicolor A3(2).
Mol Gen Genet. 2000 Jul;263(6):1053-60.
PMID: 10954092.



Comment:
For other 'mrc' genes see SMu0016 (mreC) and SMu1045 (mreA).

For other 'rod' genes see SMu1169 (rodA).



View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search
This sequence was previously published in GenBANK as gi16753178.

Several weakish matches in gapped BLAST to mreD proteins: residues 10-168 are 32% similar to the predicted mreD protein in S.pneumoniae (gi15902021). Residues 1-167 are 32% similar to this protein in Lactococcus (gi15674212).





SMu0017 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|24378549|ref|NP_720504.1|  putative cell shape-determinin...   194   1e-48
 gi|125716904|ref|YP_001034037.1|  Cell-shape determining pro...    56   1e-06
 gi|125625262|ref|YP_001033745.1|  cell shape determining pro...    55   1e-06
 gi|116513169|ref|YP_812076.1|  Cell shape-determining protei...    55   1e-06
 gi|15674212|ref|NP_268387.1|  cell shape determining protein...    54   2e-06


InterPro Summary:  InterProScan

noIPR
unintegrated
unintegrated
signalp [1-22]? NA signalp signal-peptide signal-peptide
tmhmm [10-28]? NA tmhmm transmembrane_regions[43-65]? NA tmhmm transmembrane_regions[75-95]? NA tmhmm transmembrane_regions[110-130]? NA tmhmm transmembrane_regions[140-160]? NA tmhmm transmembrane_regions transmembrane_regions


COGS Summary:  COGS Search
No hits to the COGs database.
Blocks Summary:  Blocks Search
No significant hits to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 1-164 are 28% similar to a (PROTEOME MRED COMPLETE SHAPE) protein domain (PD098799 which is seen in Q9CDJ0_LACLA.


Paralogs:  Local Blast Search
No significant paralogous sequences. Residues 13-159 are 28% similar to residues 334-476 of SMu0568, a predicted competance protein (E = 6e-04).

SMu0017 is paralogously related (blast p-value < 1e-3) to SMu0568.


Pfam Summary:  Pfam Search
Residues 2 to 166 (E-value = 9.7e-06) place SMu0017 in the MreD family which is described as rod shape-determining protein MreD (PF04093)

 Structural Feature(s):
Feature Type  Start  Stop
cleavable  
1  
55
transmembrane  
59  
75
transmembrane  
79  
95
transmembrane  
109  
125
transmembrane  
143  
159

Top PDB Hits:
No significant hits to the NCBI PDB database.

Gene Protein Sequence:
MSIFKNKLFVILFAFLMLLVDGHLSLLSRILFQNQFIVSSHFLFIVLLFY
TLVFNPYFIFGLACVLGIIYDFYYLGVYNLGIATMLYPLTIVIMFKLWKH
IPNGPVQRFLVFFILIFFLDFASIGMAYLYQLTAYPLNDFITYNLAPSLI
FNILAFLFFQKLLERIYL

Gene Nucleotide Sequence:  Sequence Viewer
ATGTCTATCTTTAAAAATAAATTATTTGTCATTTTATTTGCCTTTCTTAT
GTTACTTGTAGATGGGCATTTATCTTTATTATCACGAATCTTATTTCAAA
ATCAGTTTATTGTGTCAAGTCATTTTTTATTCATTGTGTTATTGTTTTAT
ACTCTTGTATTCAATCCTTATTTTATTTTTGGACTTGCCTGTGTTTTAGG
AATTATTTATGATTTTTATTATTTAGGGGTATATAATTTGGGAATTGCAA
CTATGTTGTATCCTTTAACAATTGTTATTATGTTTAAATTATGGAAACAT
ATTCCAAATGGTCCTGTTCAACGCTTTCTAGTTTTTTTTATCCTAATCTT
TTTTCTTGATTTTGCTAGTATTGGTATGGCCTATTTATATCAATTGACAG
CTTATCCTTTAAATGATTTTATCACTTATAATTTAGCACCTTCCTTAATT
TTTAATATACTGGCTTTTCTCTTCTTTCAAAAACTTTTAGAAAGGATTTA
CCTATGA

Los Alamos National Laboratory • Est 1943

Operated by Los Alamos National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration
Inside | © Copyright 2006 LANS LLC All rights reserved | Disclaimer/Privacy