Laboratory Methods

Information from the Center for Food Safety and Applied Nutrition and FDA

• CFSAN Laboratory Quality Assurance Manual 1995
• Drug and Chemical Residues - Methodology
  • Acrylamide: Detection and Quantitation of Acrylamide in Foods DRAFT February 24, 2003
  • Benzene: Determination of Benzene in Soft Drinks and Other Beverages May 19, 2006
  • Chloramphenicol: Methods for Residues of Chloramphenicol and Related Compounds in Foods
  • Diethylene Glycol and Ethylene Glycol: Gas Chromatography - Mass Spectrometry (GC-MS) Screening Procedure for the Presence of Diethylene Glycol and Ethylene Glycol in Toothpaste June 2007
  • Ephedrine Alkaloids: FDA's Analytical Methods for Testing of Products Believed to Contain Ephedrine Alkaloids March 2005
  • Fluoroquinolones
    • Preparation and LC/MS/MS Analysis of Honey for Fluoroquinolone Residues September 29, 2006
    • Concurrent Determination of Four Fluoroquinolones; Ciprofloxacin, Enrofloxacin, Sarafloxacin and Difloxacin in Atlantic Salmon Tissue by LC with Fluorescence Detection (determinative method for all Fluoroquinolones and all species) (available in PDF, scanned document, 4.26 Mb) October 24, 2003
    • Confirmation of fluoroquinolone residues in salmon and shrimp tissue by LC/MS: Evaluation of single quadrupole and ion trap instruments: Laboratory Information Bulletin 4298 (confirmatory testing for all Fluoroquinolones and all species) (available in PDF, 207 Kb) March 2003
    • Confirmation of Fluoroquinolones in Catfish Tissue by Electrospray LC/MS: Laboratory Information Bulletin 4108 (available in PDF, scanned document, 2.25 Mb)   August 1997
  • Furan: Determination of Furan in Foods June 2, 2005
  • Malachite Green and Metabolites; Crystal Violet and Brilliant Green
    • Quantitative and Confirmatory Analyses of Malachite Green and Leucomalachite Green Residues in Fish and Shrimp: Laboratory Information Bulletin 4363 (available in PDF, 415 Kb)  November 2005
    • Amendment: Application of Laboratory Information Bulletins 4333 and 4334 for the Determination of Leucomalachite Green and Malachite Green Residues in Catfish, Basa, Tilapia, Trout, and Shrimp    October 2005
    • Determination and Confirmation of Leucomalachite Green in Salmon: Laboratory Information Bulletin 4333 (available in PDF, 193 Kb) November 2004
    • Determination of Malachite Green and Leucomalachite Green in Salmon with In-Situ Oxidation and Liquid Chromatography with Visible Detection: Laboratory Information Bulletin 4334 (available in PDF, 190 Kb)  November 2004
    • Quantitative and Confirmatory Analyses of Crystal Violet (Gentian Violet) and Brilliant Green in Fish: Laboratory Information Bulletin 4395 May 2007; May 2008
  • Melamine and Analogues
    • Determination of Melamine and Cyanuric Acid Residues in Infant Formula using LC-MS/MS: Laboratory Information Bulletin 4421 October 2008
    • Interim Method for Determination of Melamine and Cyanuric Acid Residues In Foods using LC-MS/MS: Laboratory Information Bulletin 4422 October 2008
    • GC-MS Screen for the Presence of Melamine, Ammeline, Ammelide, and Cyanuric Acid: Laboratory Information Bulletin 4423 October 2008
    • Determination of Melamine Residues in Catfish Tissue by Triple Quadrupole LC-MS-MS with HILIC Chromatography: Laboratory Information Bulletin 4396 May 2007
  • Nitrofuran: Detection of Nitrofuran Metabolites in Shrimp April 1, 2004
  • Perchlorate: Rapid Determination of Perchlorate Anion in Foods by Ion Chromatography- Tandem Mass Spectrometry April 12, 2005
• Macroanalytical Procedures Manual 1984; Electronic Version 1998
  FDA Technical Bulletin Number 5
• Microbiological Methods
  (Includes the Bacteriological Analytical Manual)

Information from Non-Government Organizations

• AOAC International