NIDDK ADMINISTRATIVE SUPPLEMENTS FOR HUMAN EMBRYONIC CELL LINE RESEARCH

Release Date:  January 29, 2002

NOTICE:  NOT-DK-02-003

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 (http://www.niddk.nih.gov/)

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 
announces the availability of administrative supplements to NIDDK grantees to 
conduct research using human embryonic stem (ES) cell lines.  The cell line 
used must be listed on the NIH Registry of human ES cell lines 
(http://escr.nih.gov/). NIDDK-funded investigators may request an 
administrative supplement for the purpose of conducting research for any 
period, up to the duration of the currently funded project.  The parent grant 
must have at least a one year of funding period remaining at the time of the 
supplement award. Although there is no formal budget cap for these requests, 
potential applicants are strongly encouraged to contact NIDDK staff to discuss 
budgets at an early stage of the application process.

The work proposed must be within the scope of the research recommended by peer 
review.  For example, investigators carrying out animal or adult human ES cell 
work may elect to request funding to extend their investigations to human ES 
cell lines.  Investigators with current NIDDK grant support in related areas 
may also apply.  However, in all cases careful explanation and justification 
must be included to document that the proposed work is within the scope of an 
existing, funded application.  

Investigators must independently contact the human ES cell line providers 
listed on the NIH Registry and make arrangements including any required 
material transfer agreements (MTA) so the human ES cell line can be obtained. 
Applicants must indicated which human ES cell line or lines will be used and 
include a letter stating that the provider will supply the human ES cell line. 
The investigators should also demonstrate either prior ability to work with 
human ES cell lines or an outline of plans for obtaining expertise to culture 
human ES cells.  The human ES cell line providers, other laboratories with ES 
cell experience, or laboratory training courses on ES cell methods are 
potential means of obtaining this training.  Other means for acquiring human 
ES cell expertise may be proposed.

All requests for these administrative supplement awards in Fiscal Year 2002 
must be received by the NIDDK by July 1, 2002.  Awards will be made depending 
on the receipt of a sufficient number of qualified applications and the 
availability of funds.  

To apply for an administrative supplement, send an original letter and one 
copy countersigned by the grantee institution's authorized business official 
to Dr, Badman, Karp or Sato at the addresses below.  The letter (5 page limit) 
must include: 1) an abstract of the proposed supplemental activity and how it 
is related to the parent grant; 2) expected overall impact of the requested 
supplement on ongoing research results, 3) the NIH code for the human ES cell 
line(s)and a letter indicating the provider(s) will supply the cell line(s) 4) 
a justification of budget request and funding period and 5) current contact 
information for the principal investigator, including mailing and e-mail 
address.  Although these descriptions should be as concise as possible, 
sufficient detail must be provided to allow the NIDDK to determine if the 
request qualifies as an administrative supplement.

NIDDK will consider supplement requests from all eligible applicants.  
Requests will be evaluated according to the following criteria:

o The proposed research falls within the scope of the parent grant and is a 
logical extension of the goals and objectives, but not sufficiently different 
to constitute new research or program expansion.

o Evidence of prior ability to work with human ES cell lines or an outline of 
plans for obtaining expertise to culture human ES cells.  

o Documentation and justification of the requested budget.

Supplement requests will be reviewed by a committee of NIDDK program staff.  
Award decisions will be based upon the criteria provided above, availability 
of funds, and NIDDK programmatic priorities and balance. 

Direct inquiries regarding program issues to:	

Dr. David G. Badman
Division of Kidney, Urologic, and Hematologic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Blvd., Rm. 621, MSC 5458
5458, Bethesda, MD  20892-5458
(For FedEx and UPS, use Bethesda, MD  20817)
Phone:  (301) 594-7717
Fax:  301-480-3510
Email:  db70f@nih.gov

Dr.  Robert W. Karp
Division of Digestive Diseases and Nutrition
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Boulevard, Room 671,
Bethesda, MD  20892-5450
(For FedEx and UPS, use Bethesda, MD  20817)
301-451-8875  
Fax:  301-480-8300
Email:  karpr@extra.niddk.nih.gov

Dr. Sheryl Sato
Division of Diabetes, Endocrinology, and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases/NIH
6707 Democracy Plaza, Room 6105
Bethesda, MD  20892-5460
(For FedEx and UPS, use Bethesda, MD  20817)
Phone:  (301) 594-8811
Fax:  (301) 480-3503
Email:  satos@extra.nddk.nih.gov

Direct inquiries regarding fiscal issues to:

Teresa Farris Marquette
Senior Grants Management Specialist
NIDDK/DEA/GMB
Two Democracy Plaza, Room 728
6707 Democracy Blvd.
Bethesda, MD  20892-5452
(For Courier service, use Zip Code 20817)
301-594-7682 
301-480-3504 (fax)
FarrisT@extra.niddk.nih.gov

Return to Volume Index

Return to NIH Guide Main Index

	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)
Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, RealPlayer, Video or Flash files, see Help Downloading Files.