Table 21
Twenty leading causes of YLD, both sexes and all races combined
Rank   YLD % of total
  Total 15,024,113
 		 
1
 		Unipolar major depression
 		1,370,070
 		9.1%
2
 		Alcohol use
 		1,037,529
 		6.9%
3
 		Osteoarthritis
 		940,612
 		6.3%
4
 		Dementia and other degenerative and hereditary CNS disorders
 		755,925
 		5.0%
5
 		COPD
 		727,272
 		4.8%
6
 		Cerebrovascular Disease
 		725,844
 		4.8%
7
 		Asthma
 		593,233
 		3.9%
8
 		Drug use
 		504,718
 		3.4%
9
 		Diabetes mellitus
 		495,377
 		3.3%
10
 		Congenital Abnomalities
 		443,004
 		2.9%
11
 		Motor vehicle accidents
 		366,273
 		2.4%
12
 		Bipolar disorder
 		363,298
 		2.4%
13
 		Schizophrenia
 		315,720
 		2.1%
14
 		Ischaemic heart disease
 		275,988
 		1.8%
15
 		PTSD
 		260,337
 		1.7%
16
 		Panic disorder
 		259,904
 		1.7%
17
 		HIV
 		237,443
 		1.6%
18
 		Falls
 		221,036
 		1.5%
19
 		Rheumatoid arthritis
 		189,421
 		1.3%
20
 		Obsessive-compulsive disorders
 		169,067
 		1.1%

Sub-total
 		10,252,070
 		68.2%

Reference:
Michaud CM, McKenna MT, Begg S, Tomijima N, Majmudar M, Bulzacchelli MT, Ebrahim S, Ezzati M, Salomon JA, Gaber Kreiser J, Hogan M, Murray CJ. The burden of disease and injury in the United States 1996. Popul Health Metr 2006;4:11. Available at http://www.pophealthmetrics.com/content/4/1/11 (Accessed July, 19, 2007).