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- Stress-Mediated Increases in Systemic and Local Epinephrine Impair Skin Wound Healing: Potential New Indication for Beta Blockers
- HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression
- Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
- Autoimmune Responses in the Rheumatoid Synovium
- Improving Maternal and Child Health in Difficult Environments: The Case For "Cross-Border" Health Care
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Stress-Mediated Increases in Systemic and Local Epinephrine Impair Skin Wound Healing: Potential New Indication for Beta Blockers
Rivkah Isseroff and colleagues describe how stress-induced elevation of epinephrine levels can impair the healing of burns in mice and suggest that β2 adrenergic receptor antagonists may have a role in improving skin wound repair.
HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression
Maria Castro and colleagues use cell line and transgenic mouse approaches to study the mechanisms underlying the immune response to glioblastoma multiforme. The authors discuss this paper in an accompanying SciVee video.
Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
Costantino Pitzalis and colleagues show that lymphoid structures in synovial tissue of patients with rheumatoid arthritis support production of anti-citrullinated peptide antibodies, which continues following transplantation into SCID mice. The research is discussed in a Perspective by Rene Toes and Tom Huizinga.
Health in Action
The Health in Action section is a forum for individuals or organizations to highlight their innovative approaches to a particular health problem. In a Health in Action paper published this week, Gijs Walraven and colleagues discuss maternal and child health programs in adjacent geographical areas in difficult environments in Afghanistan, Pakistan, and Tajikistan. Other recent Health in Action papers published by PLoS Medicine include:
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December 2008 Issue
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From the Web
The CDC Childhood Injury Report: Patterns of Unintentional Injuries among 0-19 Year olds in the United States, 2000 – 2006 provides an overview of patterns of unintentional childhood injury in the United States related to drowning, falls, fires or burns, motor vehicle crashes, poisoning, and suffocation, among others.
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