In research mathematically simulating a flu pandemic, Joseph Wu and colleagues predict that using a secondary antiviral drug early in local epidemics would reduce global emergence of resistance to the primary stockpiled drug.
Read Article; Editors' Summary; Supporting Text; Supporting Videos: S1, S2, S3 and S4.
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Ann Killary and colleagues describe a new gene that is genetically altered in breast tumors, and that may provide a new breast cancer prognostic marker. This study is discussed in a related Perspective by Senthil Muthuswamy.
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Bruno Giraudeau and Philippe Ravaud discuss the difficulties in preventing selection bias and applying intention-to-treat analyses in cluster randomized trials, and propose some solutions.
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Marcella Sarzotti-Kelsoe and colleagues harmonize various approaches to Good Clinical Laboratory Practice for clinical trials into a single set of recommendations.
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The Guidelines and Guidance section of PLoS Medicine contains advice on conducting and reporting medical research. As well as this week's article by Marcella Sarzotti-Kelsoe and colleagues, recent Guidelines and Guidance papers include Gurdeep S Sagoo and colleagues' discussion of systematic reviews of genetic association studies and Olivier Fontaine and colleagues' discussion of the research priorities to reduce global mortality from childhood diarrhea.
In an article published recently by PLoS Medicine, Joachim Scholz and colleagues described a new standardized tool for the assessment of chronic pain. This study received international news coverage, a selection of which follows:
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