David Shotton's group from Oxford demonstrate the potential of semantically enhancing research articles, using as an example a paper from PLoS NTDs, taking advantage of the Creative Commons license and online publishing to build on and adapt scientific work.
Struggling to balance your teaching and research commitments? In the latest of our popular "Ten Simple Rules" series of Editorials, Quentin Vicens & Philip E. Bourne provide tips that should help you to get prepared for the rewarding challenge of teaching.
This article by Yasser Roudi, Sheila Nirenberg & Peter E. Latham provides a general framework for determining the extent to which pairwise models can be used to predict the behavior of large biological systems.
Wertheim & Worobey provide a temporal reference for the evolution of SIV in its natural primate hosts. They find that SIV may have infected these hosts for only hundreds of years before giving rise to HIV, casting doubt on the theory that long-term viral-host coevolution has led to SIV avirulence.
Steven A. Niederer & Nicolas P. Smith (University of Oxford) use a computational model to analyse the complex web of feedback loops which regulate heart contraction. They show that feedback at the cellular level is a key control mechanism at the whole organ level.
PLoS Computational Biology is a peer-reviewed, open-access journal featuring works of exceptional significance that further our understanding of living systems at all scales through the application of computational methods. It is an official journal of the International Society for Computational Biology.
E-mail Alerts
RSS (What is RSS?)
Join PLoSRead the PLoS Blog 
and contribute your views on scientific research and open-access publishing.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.
