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Person Details

Superfund Basic Research Program

Timothy D. Phillips

Texas A & M University
Veterinary Integrative Biosciences
404 Vet. Medical Research Bldg.
4458 TAMU
College Station, TX 77843-4458
Phone: 979-845-6414
Fax: 979-862-4929
Email:

Projects

Research Briefs

Publications

2008
  • Phillips, Timothy D., Evans Afriyie-Gyawu, Jason Williams, Henry J. Huebner, N-A Ankrah, D. Ofori-Adjei, Pauline E. Jolly, N. Johnson, John Taylor, A. Marroquin-Cardona, L. Xu, Louisa S. Tang, and Jia-Sheng Wang. 2008. Reducing human exposure to aflatoxin through the use of clay: a review. Food Additives and Contaminants. (http://www.tandf.co.uk/journals/tf/0265203X.h tml) Exit NIEHS Website doi:10.1080/02652030701567467 (http://dx.doi.org/10.1080/02652030701567467) Exit NIEHS Website25(2):134-45.
2007
  • Dash, Bhagirathi, Evans Afriyie-Gyawu, Henry J. Huebner, Weston W. Porter, Jia-Sheng Wang, Pauline E. Jolly, and Timothy D. Phillips. 2007. Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaiansf. Journal of Toxicology and Environmental Health, Part A. (http://www.tandf.co.uk/journals/titles/152873 94.asp) Exit NIEHS Website 70(1):58-66.
  • Dash, Bhagirathi, R.P. Metz, Henry J. Huebner, Weston W. Porter, and Timothy D. Phillips. 2007. Molecular characterization of two superoxide dismutases from Hydra vulgaris. Gene. (http://www.elsevier.com/wps/find/journaldescr iption.cws_home/506033/description#descriptio n) Exit NIEHS Website 387(1-2):93-108.
2006
  • Dash, Bhagirathi, Evans Afriyie-Gyawu, Henry J. Huebner, Weston W. Porter, Jia-Sheng Wang, Pauline E. Jolly, and Timothy D. Phillips. 2006. Noninvasive Identification of Interindividual Variation in Xenobiotic-Metabolizing Enzymes: Implications for Cancer Epidemiology and Biomarker Studies. Journal of Toxicology and Environmental Health, Part A. (http://www.tandf.co.uk/journals/titles/152873 94.asp) Exit NIEHS Website 69(13):1203-1216.
  • Jolly, Pauline E., Yi Jiang, William Ellis, Richard Awuah, Obinna Nnedu, Timothy D. Phillips, Jia-Sheng Wang, Evans Afriyie-Gyawu, Lili Tang, Sharina Person, Jonathan Williams, and Curtis M. Jolly. 2006. Determinants of aflatoxin levels in Ghanaians: Sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices. International Journal of Hygiene and Environmental Health. (http://www.elsevier.de/ijheh) Exit NIEHS Website 209(4):345-358.
2005
  • Afriyie-Gyawu, Evans, John Mackie, Bhagirathi Dash, Melinda C. Wiles, John Taylor, Henry J. Huebner, Lili Tang, Hongxia Guan, Jia-Sheng Wang, and Timothy D. Phillips. 2005. Chronic toxicological evaluation of dietary NovaSil clay in Sprague-Dawley rats. Food Additives and Contaminants. (http://www.tandf.co.uk/journals/tf/0265203X.h tml) Exit NIEHS Website 22(3):259-169.
  • Afriyie-Gyawu, Evans, Melinda C. Wiles, Molly B. Richardson, Christie Fickey, and Timothy D. Phillips. 2005. Prevention of zearalenone-induced hyperestrogenism in prepubertal mice. Journal of Toxicology and Environmental Health, Part A. (http://www.tandf.co.uk/journals/titles/152873 94.asp) Exit NIEHS Website 68(5):353-368.
  • Ottinger, Sean E., Rola Barhoumi, K. Scott McKenzie, Thomas J. McDonald, Robert C. Burghardt, Henry J. Huebner, and Timothy D. Phillips. 2005. FIA/MS analysis of temporally ozonated benzo[a]pyrene and pyrene and their reaction products: Inhibition of gap junction-mediated intercellular communication. Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) Exit NIEHS Website 60(8):1025-1033.
  • Wang, Jia-Sheng, H. Luo, M. Billam, Z. Wang, Hongxia Guan, Lili Tang, T. Goldston, Evans Afriyie-Gyawu, C. Lovett, J. Griswold, B. Brattin, R.J. Taylor, Henry J. Huebner, and Timothy D. Phillips. 2005. Short-term safety evaluation of processed calcium montmorillonite clay (NovaSil) in humans. Food Additives and Contaminants. (http://www.tandf.co.uk/journals/tf/0265203X.h tml) Exit NIEHS Website 22(3):270-279.
  • Wiles, Melinda C., Henry J. Huebner, Thomas J. McDonald, Kirby C. Donnelly, and Timothy D. Phillips. 2005. Matrix-immobilized organoclay for the sorption of polycyclic aromatic hydrocarbons and pentachlorophenol from groundwater. Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) Exit NIEHS Website 59(10):1455-1464.
2004
  • Herrera, P., Robert C. Burghardt, Henry J. Huebner, and Timothy D. Phillips. 2004. The efficacy of sand-immobilized organoclays as filtration bed materials for bacteria. Food Microbiology. (http://www.sciencedirect.com/science/journal/ 07400020) Exit NIEHS Website 21(1):1-10.
  • Pimpukdee, K., L.F. Kubena, C.A. Bailey, Henry J. Huebner, Evans Afriyie-Gyawu, and Timothy D. Phillips. 2004. Aflatoxin-induced toxicity and depletion of hepatic vitamin A in young broiler chicks: Protection of chicks in the presence of low levels of NovaSil PLUS in the diet. Poultry Science. (http://ps.fass.org/) Exit NIEHS Website 83(5):737-744.
  • Wiles, Melinda C., Henry J. Huebner, Evans Afriyie-Gyawu, R.J. Taylor, G.R. Bratton, and Timothy D. Phillips. 2004. Toxicological evaluation and metal bioavailability in pregnant rats following exposure to clay minerals in the diet. Journal of Toxicology and Environmental Health, Part A. (http://www.tandf.co.uk/journals/titles/152873 94.asp) Exit NIEHS Website 67(11):863-874.
2003
  • Ake, C.L., Melinda C. Wiles, Henry J. Huebner, Thomas J. McDonald, D. Cosgriff, Molly B. Richardson, Kirby C. Donnelly, and Timothy D. Phillips. 2003. Porous organoclay composite for the sorption of polycyclic aromatic hydrocarbons and pentachlorophenol from groundwater. Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) Exit NIEHS Website 51(9):835-844.
  • Bingham, A.K., Timothy D. Phillips, and J.E. Bauer. 2003. Clay-based affinity probes for the selective cleanup and analysis of aflatoxin B1 utilizing nanostructured montomorillonite on quartz. Journal of the American Veterinary Medical Association. 222(5):591-596.
  • Huebner, Henry J. and Timothy D. Phillips. 2003. Clay-based affinity probes for selective cleanup and determination of aflatoxin B1 using nanostructured montmorillonite on quartz. Journal of AOAC International. (http://www.aoac.org/pubs/pubjaoac.html) Exit NIEHS Website 86(3):534-539.
  • Huebner, Henry J. and Timothy D. Phillips. 2003. Clay-based affinity probes for the selective cleanup and analysis of aflatoxin B1 utilizing nanostructured montomorillonite on quartz. Journal of AOAC International. (http://www.aoac.org/pubs/pubjaoac.html) Exit NIEHS Website 86(3):534-539.
  • Lum, K.T., Henry J. Huebner, Y. Li, Timothy D. Phillips, and F.M. Raushel. 2003. Organophosphate nerve agent toxicity in Hydra attenuata. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 16(8):953-957.
  • Meek, I.B., A.W. Peplow, C.L. Ake, Timothy D. Phillips, and M.N. Beremand. 2003. Tri1 encodes the cytochrome P450 monooxygenase for C-8 hydroxylation during trichothecene biosynthesis in Fusarium sporotrichioides and resides upstream of another new Tri gene. Applied and Environmental Microbiology. (http://aem.asm.org/) Exit NIEHS Website 69(3):1607-1613.
  • Peplow, A.W., I.B. Meek, Melinda C. Wiles, Timothy D. Phillips, and M.N. Beremand. 2003. Tri16 is required for esterification of position C-8 during trichothecene mycotoxin production by Fusarium sporotrichioides. Applied and Environmental Microbiology. (http://aem.asm.org/) Exit NIEHS Website 69(10):5935-5940.
  • Phillips, Timothy D., S.L. Lemke, and Patrick G. Grant. 2003. Characterization of clay-based enterosorbents for the prevention of aflatoxicosis. In: Advances in Experimental Medicine and Biology. Kluwer Academic/Plenum Publishers, NY. pp.157-173.
2001
  • Ake, C.L., K. Mayura, Henry J. Huebner, G.R. Bratton, and Timothy D. Phillips. 2001. Development of porous clay-based composites for the sorption of lead from water. Journal of Toxicology and Environmental Health. (http://www.tandf.co.uk/journals/titles/152873 94.html) Exit NIEHS Website 63(6):459-475.
  • Lemke, S.L., K. Mayura, W.R. Reeves, N. Wang, Christie Fickey, and Timothy D. Phillips. 2001. Investigation of organophilic montmorillonite clay inclusion in zearalenone-contaminated diets using the mouse uterine weight bioassay. Journal of Toxicology and Environmental Health. (http://www.tandf.co.uk/journals/titles/152873 94.html) Exit NIEHS Website 62(4):243-258.
  • Lemke, S.L., Sean E. Ottinger, C.L. Ake, K. Mayura, and Timothy D. Phillips. 2001. Deamination of fumonisin B1 and biological assessment of reaction product toxicity. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 14(1):11-15.
  • Lemke, S.L., Sean E. Ottinger, K. Mayura, C.L. Ake, K. Pimpukdee, N. Wang, and Timothy D. Phillips. 2001. Development of a multi-tiered approach to the in vitro prescreening of clay-based enterosorbents. Animal Feed Science and Technology. (http://www.elsevier.com/wps/find/journaldescr iption.cws_home/503299/description#descriptio n) Exit NIEHS Website 93(1-2):17-29.
  • Reeves, W.R., Rola Barhoumi, Robert C. Burghardt, S.L. Lemke, K. Mayura, Thomas J. McDonald, Timothy D. Phillips, and Kirby C. Donnelly. 2001. Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures. Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) Exit NIEHS Website 35(8):1630-1636.
  • Reeves, W.R., Rola Barhoumi, Robert C. Burghardt, S.L. Lemke, K. Mayura, Thomas J. McDonald, Timothy D. Phillips, and Kirby C. Donnelly. 2001. Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures. Environmental Toxicology and Chemistry. (http://etc.allenpress.com/entconline/?request =index-html) Exit NIEHS Website 35:16301636.
2000
  • Barhoumi, Rola, Youssef Mouneimne, Kenneth S. Ramos, Stephen H. Safe, Timothy D. Phillips, V.E. Centonze, C. Ainley, S. Gupta, and Robert C. Burghardt. 2000. Analysis of Benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 53:264-270.
  • Herrera, P., Robert C. Burghardt, and Timothy D. Phillips. 2000. Adsorption of Salmonella enteritidis by cetyl pyridinium exchanged montmorillonite clays. Veterinary Microbiology. (http://www.sciencedirect.com/science/journal/ 03781135) Exit NIEHS Website 74:259-272.
  • Huebner, Henry J., K. Mayura, L. Pallaroni, C.L. Ake, S.L. Lemke, and Timothy D. Phillips. 2000. Development and characterization of a carbon-based composite for reducing patulin levels in apple juice. Journal of Food Protection. (http://www.foodprotection.org/publications/jf p.asp) Exit NIEHS Website 63(1):106-110.
1999
  • Huebner, Henry J., S.L. Lemke, S.E. Ottinger, K. Mayura, and Timothy D. Phillips. 1999. Molecular characterization of high affinity, high capacity clays for the equilibrium sorption of ergotamine. Food Additives and Contaminants. (http://www.tandf.co.uk/journals/tf/0265203X.h tml) Exit NIEHS Website 16:159-171.
  • Lemke, S.L., K. Mayura, S.E. Ottinger, K. Scott McKenzie, N. Wang, Christie Fickey, L.F. Kubena, and Timothy D. Phillips. 1999. Assessment of the estrogenic effects of zearalerone after treatment with ozone utilizing the mouse uterine weight bioassay. Journal of Toxicology and Environmental Health. (http://www.tandf.co.uk/journals/titles/152873 94.html) Exit NIEHS Website 56:283-295.
  • Mayura, K., Henry J. Huebner, M.R. Dwyer, K. Scott McKenzie, Kirby C. Donnelly, L.F. Kubena, and Timothy D. Phillips. 1999. Multi-bioassay approach for assessing the potency of complex mixtures of polycyclic aromatic hydrocarbons. Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) Exit NIEHS Website 38(8):1721-1732.
  • Ottinger, S.E., K. Mayura, S.L. Lemke, K. Scott McKenzie, N. Wang, L.F. Kubena, and Timothy D. Phillips. 1999. Utilization of electrochemically generated ozone in the degradation and detoxification of benzo[a]pyrene. Journal of Toxicology and Environmental Health. (http://www.tandf.co.uk/journals/titles/152873 94.html) Exit NIEHS Website 56:565-583.
  • Phillips, Timothy D. 1999. Dietary clay in the chemoprevention of aflatoxin-induced disease. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 52:118-126.
  • Springman, K.R., K. Mayura, Thomas J. McDonald, Kirby C. Donnelly, L.F. Kubena, and Timothy D. Phillips. 1999. Organoclay adsorption of wood-preserving waste from groundwater. Environmental Toxicology and Chemistry. (http://etc.allenpress.com/entconline/?request =index-html) Exit NIEHS Website 71(1-2):247-259.
1998
  • Clark, K.J., Patrick G. Grant, A.B. Sarr, J. Belakere, C. Swaggerty, Timothy D. Phillips, and G.N. Woode. 1998. An in vitro study of theaflavins extracted from black tea to neutralize bovine rotavirus and bovine coronavirus infections. Veterinary Microbiology. (http://www.sciencedirect.com/science/journal/ 03781135) Exit NIEHS Website 63:147-157.
  • Clark, K.J., A.B. Sarr, Patrick G. Grant, Timothy D. Phillips, and G.N. Woode. 1998. In vitro studies on the use of clay, clay minerals and charcoal to adsorb bovine rotavirus and bovine coronavirus. Veterinary Microbiology. (http://www.sciencedirect.com/science/journal/ 03781135) Exit NIEHS Website 63:137-146.
  • Grant, Patrick G. and Timothy D. Phillips. 1998. Isothermal adsorption of aflatoxin B1 on HSCAS clay. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 46:599-605.
  • Grant, Patrick G., S.L. Lemke, M.R. Dwyer, and Timothy D. Phillips. 1998. Modified Langmuir equation for S-shaped and multi-site isotherm plots. Langmuir. (http://pubs.acs.org/journals/langd5/index.htm l) Exit NIEHS Website 14:4292-4299.
  • Lemke, S.L., Patrick G. Grant, and Timothy D. Phillips. 1998. Adsorption of zearalenone by organophilic montmorillonite clay. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 46:3789-3796.
  • Lopez, Y., N.P. Keller, A.B. Sarr, Timothy D. Phillips, R.G. Cuero, and O.D. Smith. 1998. Visual estimation of aflatoxin production in peanut with Aspergillus norsolorinic acid mutants. Peanut Science. 25:92-99.
  • Mayura, K., M.A. Abdel-Wahhab, K. Scott McKenzie, A.B. Sarr, J.F. Edwards, K. Naguib, and Timothy D. Phillips. 1998. Prevention of maternal and developmental toxicity in rats via dietary inclusion of common aflatoxin sorbents: potential for hidden risks. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 41:175-182.
  • McKenzie, K.Scott, L.F. Kubena, A.J. Denvir, T.D. Rogers, G.D. Hitchens, R.H. Bailey, R.B. Harvey, Steven G. Buckley, and Timothy D. Phillips. 1998. Aflatoxicosis in turkey poults is prevented by treatment of naturally-contaminated corn with ozone generated by electrolysis. Poultry Science. (http://ps.fass.org/) Exit NIEHS Website 77:1094-1102.
1997
  • Donnelly, Kirby C., Timothy D. Phillips, A.M. Onufrock, S.L. Collie, and Henry J. Huebner. 1997. Genotoxicity model and complex mixtures of polycyclic aromatic hydrocarbons. In: Environmental Toxicology and Risk Assessment: Biomarkers and Risk Assessment. ASTM Special Tech. Publ. 1071-720X, Vol. 1306, Am. Soc. for Testing and Materials, Philadelphia, PA. pp.138-148.
  • Dwyer, M.R., L.F. Kubena, R.B. Harvey, K. Mayura, A.B. Sarr, Steven G. Buckley, R.H. Bailey, and Timothy D. Phillips. 1997. Effects of inorganic adsorbents and cyclopiazonic acid in broiler chickens. Poultry Science. (http://ps.fass.org/) Exit NIEHS Website 76:1141-1149.
  • McKenzie, K.Scott, A.B. Sarr, K. Mayura, R.H. Bailey, D.R. Miller, T.D. Rogers, W.P. Norred, K.A. Voss, R.D. Plattner, L.F. Kubena, and Timothy D. Phillips. 1997. Oxidative degradation and detoxification of mycotoxins using a novel source of ozone. Food and Chemical Toxicology. (http://www.sciencedirect.com/science/journal/ 02786915) Exit NIEHS Website 35:807-820.
  • Zhao, F., K. Mayura, N. Harper, Stephen H. Safe, and Timothy D. Phillips. 1997. Inhibition of 3,3',4,4',5-Pentachlorobiphenyl induced fetal cleft palate and immunotoxicity in C57BL/6 mice by 2,2',4,4',5,5'-Hexacholorobiphenyl. Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) Exit NIEHS Website 34:1605-1613.
  • Zhao, F., K. Mayura, N. Kocurek, J.F. Edwards, L.F. Kubena, Stephen H. Safe, and Timothy D. Phillips. 1997. Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl. Fundamental and Applied Toxicology. (http://www.sciencedirect.com/science/journal/ 02720590) Exit NIEHS Website 35:1-8.
1996
  • Barhoumi, Rola, Youssef Mouneimne, Timothy D. Phillips, Stephen H. Safe, and Robert C. Burghardt. 1996. Alteration of oxytocin-induced calcium oscillations in Clone 9 cells by toxin-exposure. Fundamental and Applied Toxicology. (http://www.sciencedirect.com/science/journal/ 02720590) Exit NIEHS Website 33:220-228.
  • Washburn, K.S., Henry J. Huebner, Stephen H. Safe, Timothy D. Phillips, and Kirby C. Donnelly. 1996. Development of an Instrumental Fractionation and Quantitation Scheme for Selected Polynuclear Aromatic Hydrocarbons Present in extracts from Wood-Preserving Waste. In: Proceedings of the Hazardous Substance Research Center (HSRC)/Waste-management Education & Research Consortium Joint Conference on the Environment. pp.400-407.
1995
  • Safe, Stephen H., K.S. Washburn, Timothy R. Zacharewski, and Timothy D. Phillips. 1995. Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum. Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) Exit NIEHS Website 31:3017-3023.
  • Washburn, K.S. and Timothy D. Phillips. 1995. Development of a field-practical assay for water-solvated chlorophenols. Journal of Hazardous Materials. (http://www.sciencedirect.com/science/journal/ 03043894) Exit NIEHS Website 41:371-381.
  • Zhao, F., K. Mayura, R.W. Hutchinson, R.P. Lewis, Robert C. Burghardt, and Timothy D. Phillips. 1995. Developmental toxicity and structure-activity relationships of chlorophenols using human embryonic palatal mesenchymal cells. Toxicology Letters. (http://www.sciencedirect.com/science/journal/ 03784274) Exit NIEHS Website 78:35-42.
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Last Reviewed: 19 May 2008