Volume 9, Number 4, April 2003

Molecular Epidemiology of Human Enterovirus 71 Strains and Recent Outbreaks in the Asia-Pacific Region: Comparative Analysis of the VP1 and VP4 Genes

Mary Jane Cardosa,* David Perera,* Betty A. Brown,† Doosung Cheon,‡ Hung Ming Chan,* Kwai Peng Chan,§ Haewol Cho,‡ and Peter McMinn¶
*Universiti Malaysia Sarawak, Sarawak, Malaysia; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡National Institute of Health, Seoul, Korea; §Singapore General Hospital, Singapore; and ¶Telethon Institute for Child Health Research, Perth, Western Australia, Australia

Figure 2. An overview of the genetic relationships of human enterovirus 71 (HEV71) strains isolated from 1970 through 2002. Unrooted cladogram shows the genogroup relationships of HEV71 based on an alignment of the complete VP4 gene (nucleotide positions 744–950) consensus sequences for genogroups B1, B2, B3, B4, C1, C2, and C3. The complete VP4 gene sequence of the prototype strain BrCr-CA-70 (30) was used as an outgroup in the analysis. The bootstrap values in 1,000 pseudoreplicates for major lineages within the dendrogram are shown as percentages. The marker denotes a measurement of relative phylogenetic distance.

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This page last reviewed March 18, 2003

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
Centers for Disease Control and Prevention