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Neurotoxicity

Superfund Basic Research Program

Neurotoxicity occurs when the exposure to natural or manmade toxic substances (neurotoxicants) alters the normal activity of the nervous system. This can eventually disrupt or kill neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from exposure to several contaminants that are commenly found at hazardous waste sites including heavy metals such as lead and mercury, pesticides, and industrial and/or cleaning solvents. Symptoms may appear immediately after exposure or be delayed and may include limb weakness or numbness, loss of memory, vision, and/or intellect, headache, cognitive and behavioral problems and sexual dysfunction.

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Last Reviewed: 19 May 2008