endothelin-1 protein receptor antagonist (EN-doh-THEE-lin ... PROH-teen reh-SEP-ter an-TAG-uh-nist)
A substance that blocks the binding of the endothelin-1 protein to its receptor. Endothelin-1 is a small molecule that causes changes in blood vessels and helps regulate blood pressure. It can also stimulate the growth of some types of cells.