Clinical Research - Diabetes

Clinicalresearch is patient-oriented research. Research may be conducted inhuman volunteers or on samples from humans. NIH-funded studies arecarefully designed to answer specific medical questions whileprotecting participants' safety. Well conducted clinical trials are thefastest and safest way to find improved treatments and preventions fordiseases. Clinical trials or interventional trials determine whetherexperimental preventions, treatments, or new ways of using knowntherapies are safe and effective under controlled conditions.Observational or natural history studies examine health issues anddisease development in groups of people or populations. The NationalLibrary at Medicine explains more about clinical research in Understanding Clinical Trials.

• Recruiting
• Completed
• Ongoing - No Longer Recruiting
• Follow-up Studies
• Consortia, Registries, Repositories

• The Action to Control Cardiovascular Disease Risk in Diabetes (ACCORD)
  NIDDK is co-funding a study to test best ways to lower risk of heart disease and stroke in adults with type 2 diabetes.
  
  
• Bypass Angioplasty Revascularization Investigation (BARI) 2 Diabetes
  | www.bari2d.org/ 
  This study, co-funded by NIDDK, aims to determine the best therapies for people with type 2 diabetes and heart disease.
  
  
• Diabetes Research in Children Network (DirecNet) 
  | http://public.direc.net/
  This clinical center network is researching the potential use ofglucose monitoring technology and its impact on the management of type1 diabetes in children.
  
  
• Immune Tolerance Network (ITN)
  | www.immunetolerance.org/index.shtml 
  NIDDK co-funds this international consortium dedicated to evaluatingnew treatments for autoimmune diseases, asthma, and allergic diseases,and to preventing rejection of transplanted kidneys and pancreaticislets.
  
  
• Islet Transplantation Trials for Type 1 Diabetes  
  Various research centers are performing islet transplantations in a small number of adults with type 1 diabetes.
  
  
• SEARCH for Diabetes in Youth Study
  | www.searchfordiabetes.org/
  This study, co-funded by NIDDK, will determine the prevalence ofdiabetes in children in six areas of the U.S. and help clarify trendsin the development of diabetes in youth.
  
  
• TODAY Trial
  The TODAY (Treatment Options for type 2 Diabetes in Adolescents andYouth) study, which seeks to identify the best treatment of type 2diabetes in children and teens, has begun in 12 medical centers andaffiliated sites around the country.
  
  
• Type 1 Diabetes Special Funding Studies
  Severalstudies are recruiting type 1 diabetes patients (including new-onsetpatients) and their family members. These studies are supported by aspecial type 1 diabetes research program.
  
  
• Type 1 Diabetes TrialNet
  Type1 Diabetes TrialNet is a network of clinical centers, experts indiabetes and immunology, and specialized laboratories dedicated totesting new approaches to understanding and preventing type 1 diabetes.This clinical research program seeks to prevent type 1 diabetes inhigh-risk people and to preserve insulin production in those newlydiagnosed. Patient recruitment for upcoming trials is planned for thebeginning of 2004.
  
  
• ClinicalTrials.gov
  For other studies in diabetes, search this comprehensive database.
  
  

• Look AHEAD: Action forHealth in Diabetes
  Look AHEAD (Action For Health in Diabetes) is a randomized clinicaltrial in people with type 2 diabetes that examines the effects ofweight loss over the long term through decreased caloric intake andexercise.
  
  
• Diabetes Prevention Program Outcomes Study (DPPOS)
  DPPOS is studying the long term effect of diet and exercise and thediabetes medication, metformin, on the delay of type 2 diabetes inparticipants of the Diabetes Prevention Program (DPP).
  
  
• Epidemiology of Diabetes Interventions and Complications (EDIC) Study
  EDIC is studying the long-term complications of type 1 diabetes in participants of the Diabetes Control and Complications Trial.
  
  

• Diabetes Control and Complications Trial (DCCT)
  The DCCT is a clinical trial showing that blood glucose levels kept asclose to normal as possible slows the onset and progression of eye,kidney, and nerve diseases caused by diabetes. Epidemiology of Diabetes Interventions and Complications (EDIC) Study is a follow -up study of the participants in the DCCT.
  
  
• Diabetes Prevention Trial--Type 1
  Both trials of the DPT-1--the low-dose insulin injection trial in people at high risk for type 1 diabetes and the oral insulin trialin people at moderate risk for type 1 diabetes--have ended. Althoughneither approach was able to prevent the development of type 1diabetes, researchers in Type 1 Diabetes TrialNet are continuing the search for ways to prevent or slow the autoimmune destruction of beta cells.
  
  
• Diabetes Prevention Program (DPP)
  Diet and exercise dramatically delay type 2 diabetes. Diabetes medication metformin is also effective in cutting risk. Diabetes Prevention Program Outcomes Study (DPPOS) is a follow-up study to the participants enrolled in the DPP study.
  
  

• Diabetes Prevention Program Outcomes Study (DPPOS)
  DPPOS is studying the long term effect of diet and exercise and thediabetes medication, metformin, on the delay of type 2 diabetes inparticipants of the Diabetes Prevention Program (DPP).
  
  
• Epidemiology of Diabetes Interventions and Complications (EDIC) Study
  EDIC is studying the long-term complications of type 1 diabetes in participants of the Diabetes Control and Complications Trial.
  
  

• Beta Cell Biology Consortium (BCBC)
  The mission of the Beta Cell Biology Consortium (BCBC) is to facilitateinterdisciplinary approaches that will advance the understanding ofpancreatic islet development and function.
  
  
• Collaborative Islet Transplant Registry
  The CITR expedites progress and promotes the safety of islettransplantation by collecting, analyzing, and communicating data onislet transplants in the U.S. and Canada.
  
  
• Endocrine Pancreas Consortium
  The Endocrine Pancreas Consortium was formed in late 1999 to derive andsequence cDNA libraries enriched for rare transcripts expressed in themammalian endocrine pancreas.
  
  
• Environmental Determinants of Diabetes in the Young (TEDDY)
  | www.teddystudy.org/
  This consortium is organizing international efforts to identifyinfectious agents, dietary factors, or other environmental factors thattrigger type 1 diabetes in genetically susceptible people.
  
  
• Genetics of Kidneys in Diabetes (GoKinD)
  The purpose of the GoKinD Study is to establish a repository of DNA andclinical information from 1,100 adults with Type 1 diabetes, along withtheir parents to better understand how genetics contributes to thedevelopment of diabetic kidney disease.
  
  
• International Type 1 Diabetes Genetics Consortium
  This consortium is organizing international efforts to identify genes that determine a person's risk of type 1 diabetes.
  
  
• International Type 2 Diabetes Linkage Analysis Consortium
  This consortium is organizing international efforts to combine existingdata sets for linkage analysis in an effort to map genes for type 2diabetes. In addition, the availability of a large number of samplesallows for analysis of individual ethnic groups for predominantdiabetes susceptibility genes.
  
  
• Islet Cell Resource Centers
  The mission of the Islet Cell Resource Centers (ICRs) is to providepancreatic islets for basic science studies and clinical trials and tooptimize the harvest and shipment of islets while developing tests thatcharacterize the quality and predict the effectiveness of isletstransplanted into patients with diabetes mellitus.
  
  
• NIDDK Central Repositories
  The Biosample, Genetics, and Data Repositories have been established tostore biosamples and data collected in designated NIDDK-funded clinicalstudies. The purpose of the NIDDK Central Repositories is to expand theusefulness of these studies by allowing a wider research community toaccess these materials beyond the end of the study.
  
  
• Type 1 Diabetes Special Funding Program
  Information on research funding opportunities, resources, consortia,and networks supported by the Special Funding Program for Type 1Diabetes Research.