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Multiple drug-resistant Chlamydia trachomatis associated with
clinical treatment failure.
Journal of Infectious Diseases 2000;181(4):1421-1427.
Somani J, Bhuller VB, Workowski KA, Farshy CE, Black CM.
Abstract
In vitro susceptibility testing and genotyping were done on urogenital isolates
of Chlamydia trachomatis from 3 patients, 2 of whom showed evidence of clinical
treatment failure with azithromycin and one of whom was the wife of a patient.
All 3 isolates demonstrated multidrug resistance to doxycycline, azithromycin,
and ofloxacin at concentrations >4.0 microg/mL. Recurrent disease due
to relapsing infection with the same resistant isolate was documented on
the basis of identical genotypes of both organisms. This first report of
clinically significant multidrug-resistant C. trachomatis causing relapsing
or persistent infection may portend an emerging problem to clinicians and
public health officials.