FY 2009 Budget
Authorizing Legislation: Section 301 and Title IV of the Public Health Service Act, as amended.
This document provides justification for the Fiscal Year (FY) 2009 activities of the National Institute of Environmental Health Sciences (NIEHS), including HIV/AIDS activities. Details of the FY 2009 HIV/AIDS activities are in the Office of AIDS Research (OAR) Section of the Overview. Details on the Common Fund are located in the Overview, Volume One. Program funds are allocated as follows: Competitive Grants/Cooperative Agreements; Contracts; Direct Federal/Intramural and Other. DIRECTOR'S OVERVIEWThe impact of environmental health science research on decisions to reduce exposure to contaminants such as ozone, air particulates, dioxin, lead and mercury, in order to predict and preempt disease before symptoms and damage occur, is familiar to most. Many of the decisions resulting in these reductions have been based on results of NIEHS-supported research and have had a tremendous health impact in reducing the risks to environmentally influenced cardiopulmonary deaths, cancers, asthma and neurobehavioral problems. Environmental health science covers a wide spectrum, including understanding exposure-disease relationships grounded in a vast body of research that examines cellular and molecular responses to toxicants and the genetic susceptibilities than can alter these responses. While less visible to the public, this body of work touches the everyday lives of many Americans. As an example, look no further than a recently prescribed bottle of Coumadin. Coumadin, a brand name of the blood-thinner warfarin, is the first widely-used drug to include genetic testing information on its label, moving the concept of personalized medicine into the mainstream. This was possible because an NIEHS-supported scientist discovered a variant of the enzyme responsible for breaking down, or metabolizing, warfarin. This variant metabolizes warfarin poorly, so this discovery was key to identifying which patients would need a lower dose, as excess levels of warfarin increase the risk of bleeding. This work was part of a broad effort at NIEHS to understand the important enzyme system that metabolizes environmental agents: the cytochrome P-450 system. NIEHS-supported researchers made key discoveries in this family of enzymes, identifying the genes coding, the different variants of these genes and the consequence of these variations on enzyme activity and toxicity. This information has been useful to the pharmaceutical industry because the same enzymes act to break down pharmaceuticals. Thus, NIEHS-supported research has led to greater understanding of how individuals can differ in the way they respond to identical doses of a drug. This will become increasingly important as genetic testing techniques become less expensive and doses can be tailored in ways that reduce unwarranted side effects. The P-450 system is one of several important environmental response pathways of relevance in molecular toxicology. Understanding the consequences of genetic damage by environmental agents has been another extensive field of study. The genetic code embedded in DNA is critical to normal cell functioning and to life itself. It is vulnerable to damage and to mistakes made when DNA is duplicated during cell division; any alterations to the DNA code arising from these events can translate into serious health consequences. For this reason, the body has elaborate systems for identifying damage to DNA, for repairing this damage, and for excising areas that are damaged. NIEHS has supported extensive research examining the biological and clinical consequences of alterations in DNA arising from mutations caused by environmental agents or by mistakes in routine events such as replication. This work has helped identify the different types of "breaks" that can occur in DNA and the complex enzymatic repair mechanisms that attempt to correct this damage. Insights from this research have led to the development of signatures or fingerprints of cellular response that hold promise for identifying environmental causes of disease in human populations with a precision that has not previously been possible. Proof of the value of this concept has recently been demonstrated in studies in the Balkans. Balkan endemic nephropathy is a disease people in the Balkans have suffered from for hundreds of years, causing kidney failure and malignant tumors of the urinary tract. Reading about the symptoms of Balkan endemic nephropathy, an NIEHS grantee was struck by how much it resembled kidney damage found in people that used the Chinese herbal medicine Aristolochia. He assembled a multidisciplinary research team in the Balkans and the U.S. and was able to discover the way in which Aristolochia, growing as weeds in wheat fields, entered the food supply. Using new molecular techniques, this research team identified two distinct DNA binding sites, or adducts, of Aristolochia that could be assayed in the tissues of patients to assess exposure to this herb. Additionally, they built on this research to discover the actual mutational changes that gave rise to the urinary tract cancers. The DNA adducts and mutational changes were also validated as "fingerprints" that were subsequently used to verify that chronic dietary poisoning by aristolochic acid was responsible for endemic nephropathy and its associated urothelial cancer (PNAS, 2007, 104:12129-12134). This herb, used in folk medicine throughout the world, is now being investigated by other governments who can use the molecular fingerprint techniques to investigate if a large portion of kidney failure cases in their own countries arise from exposure to this herb. More importantly, this work validates the technique of using cellular fingerprints for identifying chronic environmental exposures that can produce clinical disease years after initial exposures. This ability should greatly accelerate our understanding of the environmental underpinnings of common diseases and help eliminate them. There is a broader importance in defining environmental response pathways. The body is frugal and uses the same pathways for responding to environmental agents and to oxidants released during digestion of foods or during energy generation, in responding to drugs and in responding to pathogenic attack. Thus, all research in molecular toxicology reveals important insights into normal cellular pathways and responses. New advances in genomic technologies have greatly expanded our ability to understand these processes through the identification of the actual genes that control the multiple response pathways that are elicited by toxicant exposures. Combined with improved exposure assessment technologies that will emerge from the NIH-wide Genes, Environment and Health Initiative, researchers will have a greater ability to identify exposure-disease linkages important to the public health. In these ways, the field of environmental health science will move our country to a future where the prevention of disease will be the norm, obviating the need for expensive treatments to ameliorate disease once it has occurred. JUSTIFICATION BY ACTIVITYProgram Descriptions and AccomplishmentsLinkage of Exposures to Clinical Expression of Disease: Studying individual patients increases our understanding of environmental causes of common, complex diseases, and thus enables the development of improved research models for human disease. This program encourages partnerships between clinical investigators and other researchers in environmental health sciences. This program also provides important clinical insight into the environmental underpinnings of degenerative diseases, cardiovascular diseases, reproductive disorders, breast cancer, and lung diseases. A recent NIEHS-sponsored report shows links between exposure to lead and the risk of heart disease in aging men. Men with the highest blood or bone lead levels had more heart attacks or angina than men with lower overall lead exposure. The lead levels correlated with an approximate 25 percent increase in risk for ischemic heart disease, suggesting that the health effects of lead exposure can persist long after the initial exposure occurs. Budget Policy: The FY 2009 budget estimate for the Linkage of Exposures to Clinical Expression of Disease program is $57.8 million, which represents a reduced funding level of -$253 thousand and -.4% from the FY 2008 estimate. Resources will be used to continue activities critical to the long-term success of the program. These include programs to identify windows of susceptibility to breast cancer development from the prenatal period to adulthood, and continuation of the Sister Study, which studies sisters of women diagnosed with breast cancer, to target environmental and genetic causes of breast cancer. In addition, NIEHS will continue funding a cohort study of 6,000 children from 12 communities in Southern California, examining genetics, air pollution, and children's respiratory health, with a goal of identifying environmental and host factors, and examining the genetic variation in oxidative stress pathways that modulate response to air pollution. Basic Mechanisms in Human Biology: The Basic Mechanisms in Human Biology program employs environmental toxicants as laboratory probes to study the complex molecular pathways that lead to chronic disease. Environmental toxicants can interrupt normal processes and set in motion events leading to disease. This program helps to identify methods to diagnose those diseases before they are clinically evident and develop early interventions to prevent progression to end-stage disease. In 2007, the National Toxicology Program (NTP), a toxicological testing program headquartered at NIEHS, began including results of its short-term studies on the NTP website, in addition to results of it's two-year cancer bioassays that were already available. Greater access to information increases the public's understanding of the toxic potential of chemicals to which they may be exposed and enhances the ability of scientists worldwide to build upon results arising from NTP studies for use in making public health decisions. Budget Policy: The FY 2009 budget estimate for the Basic Mechanisms in Human Biology program is $246 million, which represents a funding level of -$2.9 million and -1.1% from the FY 2008 estimate. NIEHS anticipates that several initiatives in capacity building in environmental genomics will have essentially been completed, reducing resources required for this program. While modest investments in these areas will continue, resources will primarily be directed to high-priority activities critical to the long-term success of the Basic Mechanisms in Human Biology program, and to address research questions and concerns with the highest priorities.
Interdisciplinary, Integrative Research: The purpose of NIEHS' Interdisciplinary, Integrative Research program is to coordinate and integrate scientific contributions from all levels of investigators in many fields, such as epidemiology, toxicology, molecular and cellular biology, bioinformatics, clinical medicine. Fostering such broad-based, collaborative research increases the relevance of basic scientific discoveries in environmental health sciences to human disease with more rapid and effective knowledge into clinical and public health applications to ultimately improve human health. NIEHS grantees recently reported that children living within 500 meters of freeways in California have reduced lung-function compared to children living 1,500 meters or more from freeways. The research points to diesel exhaust as an important component of the impaired lung function. This shows that some children are at a higher risk than others of adverse respiratory effects resulting from environmental pollutants. Budget Policy: The FY 2009 budget estimate for the Interdisciplinary, Integrative Research program is $61.7 million, which represents a reduced funding level of -$.9 million and -1.6% from the FY 2008 estimate. Resources for the Interdisciplinary, Integrative Research program will be used to continue high priority projects to optimize the Interdisciplinary and Integrative Research program. These include grants awarded under the DISCOVER program, which fosters collaborations across teams of scientists with complementary skills and areas of expertise. Support is also provided for the Centers for Children's Environmental Health and Disease Prevention Research and an RFA, Centers for Neurodegeneration Science that NIEHS is funding in conjunction with the National Institute of Aging. In addition, NIEHS will continue designing and implementing several new models for research that integrate clinical, epidemiological, and toxicological research with basic mechanistic studies to address disease cause, development, susceptibility, and progression.
Community-linked and Global Environmental Health Research: The goal of the Community-linked and Global Environmental Health Research program is to better understand how differences in the environment contribute to the excess burden of disease in minority and disadvantaged communities, creating health disparities in the U.S. and around the world. This program explores evidence that poor and minority groups are disproportionately exposed to hazardous substances such as metals, pesticides, wood dusts, and air pollutants, which can lead to shorter life expectancies, higher cancer rates, more birth defects, greater infant mortality, and higher incidences of asthma, diabetes, and cardiovascular disease. NIEHS held a workshop in 2007 to evaluate opportunities in global environmental health to identify potential partners, as well as possible barriers. This workshop's success and identification of key issues led to a forum nine months later with the inclusion of foundations and non-government organizations (NGOs). This meeting was designed to foster informal collaborative networks among U.S. and foreign public and private sector organizations. Participants focused on identifying cost-effective, sustainable partnership strategies with government agencies, foundations, NGOs, community groups and private industry to apply environmental health science in the developing world to improve human health. Budget Policy: The FY 2009 budget estimate for the Community-linked and Global Environmental Health Research program is $33.1 million, which represents a funding level of +$1.3 million and +4.1% from the FY 2008 estimate. NIEHS is developing a unified program referred to as "Partnerships for Environmental Public Health" that will support a variety of research, outreach and education activities to prevent, reduce, or eliminate environmental exposures that may lead to adverse health outcomes in communities, with the active participation of those communities in all stages of the work. Exposure Biology/Exposure Measurement: The Exposure Biology/Exposure Measurement program supports efforts to increase our understanding of the biological pathways involved in host response to a given exposure. The program seeks to develop improved methods to detect and measure environmental exposures sustained by humans or other organisms. NIEHS awarded twenty grants in 2007 to develop new personal monitors that can be worn by people to measure environmental factors. The information revealed by these devices can be cross-referenced to underlying genetic susceptibilities in these individuals in ways that will improve our understanding of how genes and environment interact in human health and disease. This more precise understanding of individual risks and exposures will greatly enhance people's ability to participate in partnership with their physicians to manage their health. Diseases for which greater understanding can be developed in this way include cancer, heart disease, asthma, and diabetes. Budget Policy: The FY 2009 budget estimate for the Exposure Biology/Exposure Measurement program is $24.3 million, which represents a reduced funding level of -$187 thousand and -.8% from the FY 2008 estimate. Resources will be used to continue high priority projects to optimize the Exposure Biology/Exposure Measurement program. These include development of biomarkers that would 1) be accurate for the relevant timeframes (such as previous or historical exposures); 2) be mechanistically linked to diseases of interest; and 3) serve to link environmental exposures with biological effects. Research areas with a critical need for specific biomarkers include common biological responses (inflammation, oxidative stress, apoptosis, and DNA damage), markers of gene and protein expression, and markers of organ dysfunction. Pathways for Future Environmental Health Scientists: The Pathways for Future Environmental Health Scientists program's goal is to continue to attract the brightest young students and scientists into the environmental health sciences field to have the right cadre to conduct the interdisciplinary research demanded. The program includes efforts at the high school and undergraduate level (opportunities for laboratory-based training), the graduate level (institutional and individual training grants including a new training initiative designed to prepare individuals to study environment and genetic factors in disease etiology), and at the faculty level (Outstanding New Environmental Scientist (ONES) grants and short term sabbatical awards). In fiscal years 2006 and 2007, NIEHS' ONES program awarded 5-year grants totaling approximately $7.1 million to exceptionally talented and creative new scientists to pursue careers in environmental health research. These grantees are in the early, formative stages of their careers and intend to make a long term career commitment to research in the mission areas of NIEHS. The grants will assist them in launching an innovative research program focusing on problems of environmental exposures and human biology, human pathophysiology and human disease. Budget Policy: The FY 2009 budget estimate for the Pathways for the Future Environmental Health Scientists program is $29.3 million, which represents a funding level of +$.7 million and +2.3% from the FY 2008 estimate. Resources will be used to continue high priority projects to strengthen the Pathways for the Future Environmental Health Scientists program. These include 1) the ONES program, an R01 program for new independent investigators; 2) re-engineering the NIEHS training grant program to increase participation of physician-scientists in environmental sciences research; 3) promoting the NIEHS MD/PhD program; 4) continuing the Institutional Career Development Program (a program of K12 awards to support the early career development of patient-oriented researchers in the environmental health sciences); 5) continuing a joint training program in environmental genetics and genomics, co-sponsored with NHGRI; and 6) supporting the NIH Pathway to Independence program. Intramural Research: The Intramural Research program's mission is to investigate the role of environmental agents in human disease and dysfunction and define the important biological and chemical processes that these agents act upon. NIEHS' intramural research studies are often long-term and high-risk in nature with unique components, such as NIEHS' contribution to the NTP, epidemiological studies of environmentally associated diseases, and intervention and prevention studies in humans to reduce the effects of exposures to hazardous environments. NIEHS scientists recently made an important discovery about a critical new role that an enzyme called DNA polymerase epsilon plays in replicating DNA in higher organisms, such as yeast, and perhaps even humans. The researchers used an innovative strategy to demonstrate that in bakers yeast, DNA polymerase epsilon has a primary role in replicating the leading strand of DNA. DNA polymerase epsilon was found to be a key determinant of preserving the precise coding of DNA as well as of cellular responses to DNA damage resulting from exposures to environmental stress. Budget Policy: The FY 2009 budget estimate for the Intramural Research program is $172.9 million, which represents a funding level of +$2.6 million and +1.5% from the FY 2008 estimate. Resources will be directed to high priority areas in the Intramural Research program, such as clinical studies and interdisciplinary research programs designed to understand human disease and improve human health. Research Management and Support (RMS): The RMS program provides administrative, budgetary, logistical, and scientific support in the review, award, and monitoring of research grants and training awards. NIEHS currently oversees approximately 670 research grants and centers. Other RMS functions also include strategic planning, coordination, and evaluation of NIEHS programs, regulatory compliance, international coordination, and liaison with other federal agencies, Congress, and the public. Budget Policy: The FY 2009 budget estimate for RMS is $17.7 million, which represents a funding level of +$270 thousand and +1.5% from the FY 2008 estimate. Resources will be used to continue funding the important RMS activities mentioned above which support the infrastructure that allows NIEHS to pursue and achieve its mission. NIH Common FundNIEHS is the lead institute for the Roadmap Epigenomics Program supported through the NIH Common Fund, which will continue in FY 2009. |
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