Volume 10, Number 12, December 2004

Novel Avian Influenza H7N3 Strain Outbreak, British Columbia

Martin Hirst,* Caroline R. Astell,* Malachi Griffith,* Shaun M. Coughlin,* Michelle Moksa,* Thomas Zeng,* Duane E. Smailus,* Robert A. Holt,* Steven Jones,* Marco A. Marra,* Martin Petric,† Mel Krajden,† David Lawrence,† Annie Mak,† Ron Chow,† Danuta M. Skowronski,† S. Aleina Tweed,† SweeHan Goh,† Robert C. Brunham,† John Robinson,‡ Victoria Bowes,‡Ken Sojonky,‡ Sean K. Byrne,‡ Yan Li,§ Darwyn Kobasa,§ Tim Booth,§ and Mark Paetzel¶
*British Columbia Cancer Agency (BCCA) Genome Sciences Centre, Vancouver, British Columbia, Canada; †British Columbia Centre for Disease Control and University of British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada; ‡Ministry of Agriculture, Abbotsford, British Columbia, Canada; §Canadian Centre for Human and Animal Health, Winnipeg, Manitoba, Canada; and ¶Simon Fraser University, Burnaby, British Columbia, Canada

Appendix Figure 3. A structure-based sequence alignment of the influenza A virus hemagglutinin precursor protein from human A/Canada/504/04 (Hu504) with that of the hemagglutinin precursor protein (HA0) from influenza A virus, human strain CV-1 whose structure was solved by Wiley and colleagues in 1998 (PDBcode 1HAO) (6). The alignment shows 49.9% identity in sequence. Insertions and deletions are highlighted in grey and nonconservative mutations are shown in yellow. Conserved cysteines are boxed. The glycosylated aparagines which are conserved are boxed with thin lines; the glycosylated asparagines that are not conserved are boxed with thick lines.

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This page last reviewed November 8, 2004

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
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