Volume 10, Number 11, November 2004

Topographic Changes in SARS Coronavirus–infected Cells at Late Stages of Infection

M.L. Ng,* J.W.M. Lee,* M.L.N. Leong,* A.-E. Ling,† H.-C. Tan‡ and E.E. Ooi‡
*National University of Singapore, Singapore; †Singapore General Hospital, Singapore; and ‡National Environment Agency, Singapore

Figure 2. Scanning electron microscopy of Vero E6 cells infected with severe acute respiratory syndrome–associated coronavirus at 15 h after infection. A) One pronounced surface morphologic change is the proliferation of psuedopodia at the cell periphery (arrows). Some pseudopodia are also developing on the cell surface. Some cells appear to have large amount of extracellular virus on the cell surface (arrowhead), whereas neighboring cells seem deprived of any extracelluar virus particles. B) Virus particles are protruding from the edge of cells (arrows). Inset shows the boxed area at higher magnification. Virus particles appear knobby and rosettelike.

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This page last reviewed October 4, 2004

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
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