Project Number: 6406-32000-010-01
Project Type: Specific Cooperative Agreement

Start Date: Sep 21, 2007
End Date: Jul 14, 2009

Objective:
The objectives of this work are to identify important virulence (e.g. colonization/ adhesion factors) proteins of Mycoplasma gallisepticum via a proteomic approach and to subsequently apply the obtained knowledge towards a greater understanding of the mycoplasmosis disease process towards development of novel means of control.

Approach:
Initially, candidate proteins will be identified via proteomic comparisons of pathogenic Mycoplasma gallisepticum strains and their non-pathogenic derivatives. Differential protein expression will be determined and proteins of interest identified. Time and resource permitting, similar investigations may be performed to compare the proteomes of Mycoplasma gallisepticum vaccine strains and pathogenic field strains. Knowledge attained will be applied towards understanding the mycoplasmosis disease process and towards the development of novel means of control.