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Alternative Methods to the Mouse LD50 Assay for Botulinum Toxin Potency Testing
A request for comments, nominations of experts, and submission of data for a proposed workshop on alternative methods to replace the Mouse LD50 Assay for Botulinum Toxin Potency Testing was announced in the Federal Register on January 27, 2006 (Vol. 71, No. 18, pp. 4603-4).

Alternative Test Method Evaluations
Interagency Coordinating Committee on the Validation of Alternative Methods.
Links to information about the reviews of alternative test methods, the respective categories of toxicity, and/or the ICCVAM Working Group assigned to the assays.

A Good Practice Guide to the Administration of Substances and Removal of Blood, Including Routes and Volumes
European Federation of Pharmaceutical Industries Associations and European Center for the Validation of Alternative Methods.
Provides researchers in safety evaluation laboratories with an up-to-date, easy to use set of data sheets to aid in the study design process while at the same time affording maximum welfare considerations to the experimental animals.

Murine Local Lymph Node Assay (PDF|9.18 MB)
Interagency Coordinating Committee on the Validation of Alternative Methods; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods.
The Murine Local Lymph Node Assay (LLNA) is an alternative test method for assessing the allergic contact dermatitis potential of chemicals.

Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity
DHHS. NIH. National Institute of Environmental Health Sciences. National Institutes of Health.
Describes how to use in vitro cytotoxicity tests to estimate starting doses for acute oral lethality assays.

An alternative method for rat fixation when giving subcutaneous, intramuscular and intraperitoneal injections ("Camilla´s method")
Scandinavian Journal of Laboratory Animal Science.
The authors discuss a less stressful method for restraining rats when giving injections.

Last Modified: Aug 7, 2008

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