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Descriptions of NTP Study Types
Descriptions of NTP Study Types
Home » Testing Information » Descriptions of NTP Study Types » Developmental » Abstracts » Abstract for Teratology: Ethylene glycol diethyl ether
ABSTRACT
Ethylene glycol diethyl ether (EGDE), a member of the glycol ether class of industrial solvents, was evaluated for toxic and teratogenic effects in timed-pregnant New Zealand White rabbits. Animals were exposed to EGDE in water, by gavage on gestational days (gd ) 6 through 19 and sacrificed on gd 30. Prior to initiation of the teratology study, a preliminary study was conducted in order to establish appropriate doses for use in the teratology study. Based on the results of the preliminary study, doses of 0, 25, 50 and 100 mg/kg/day EGDE were administered in the teratology study.
The teratology study was conducted using a three replicate design, with 12-14 animals assigned to each dose group in each replicate. A total of 26-32 does (i.e., confirmed-pregnant females) per treatment group were evaluated in the study, with the following results:
In conclusion, exposure of timed-pregnant New Zealand White rabbits to EGDE during gestation resulted in clearcut evidence of developmental toxicity at doses of 50 mg/kg/day and above, in the absence of clearcut maternal toxicity.
Report Date: October 16, 1987
Web page last updated on September 29, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.