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Humane Endpoints and Euthanasia
 
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Humane Endpoints and Euthanasia
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Humane endpoints are chosen to minimize or terminate the pain or distress of the experimental animals via euthanasia rather than waiting for their deaths as the endpoint.

Animal Euthanasia, 2007
USDA. NAL. Animal Welfare Information Center.
This publication contains citations pertinent to the humane euthanasia of animals. It is divided into 8 groups as follows: Aquatic Animals, Birds, Dogs and Cats, General, Livestock, Reptiles, Rodents and Rabbits, Wildlife: Captive and Free Ranging.
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Newcastle Consensus Meeting on Carbon Dioxide Euthanasia of Laboratory Animals, February 2006  (PDF|123KB)
In February 2006 a meeting was held at the University of Newcastle in the United Kingdom to bring together scientists who have examined CO2 as a euthanasia agent.
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AVMA Guidelines on Euthanasia  (PDF|160 KB)
American Veterinary Medical Association.
This June 2007 report provides recommendations to give veterinarians guidance in relieving pain and suffering of animals that are to be euthanatized.
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Guidance Document on the Recognition, Assessment, and Use of Clinical Signs as Humane Endpoints for Experimental Animals Used in Safety Evaluation
Organisation for Economic Co-operation and Development.
The purpose document is to apply the principles of the 3Rs to the use of animals in regulatory toxicity tests. It specifically focuses on refinement and is available as a PDF or DOC.
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Guidelines for Endpoints in Animal Study Proposals  (PDF|44 KB)
DHHS. NIH. Office of Animal Care and Use.
This document states that selection of appropriate endpoints requires careful consideration of the study's scientific requirements, possible pain, distress or illness the research animals may experience, the most likely time course and progression of those adverse effects, and the earliest most predictive indicators of present or impending adverse effects.
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Animal Euthanasia, 1997
USDA. NAL. Animal Welfare Information Center.
Last updated in 1997, this bibliography provides citations on euthanatizing methods for a variety of animal species in different circumstances.
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Humane Endpoints Database
Johns Hopkins Center for Alternatives to Animal Testing.
Hosted by Altweb, this database has over 200 records on articles published between 1998 and 2003 on the topic of humane endpoints.
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Humane Endpoints in Animal Experimentation for Biomedical Research: Ethical, Legal and Practical Aspects  (PDF|72 KB)
International Journal of Laboratory Animal Science and Welfare.
This article discusses the reasons for implementing humane endpoints.
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Use of Humane Endpoints in Biomedical Research
Working Group on Humane Endpoints.
The proceedings of two international conferences that address issues relating to the recognition and assessment of adverse effects in animals, and the determination, validation and acceptance of humane endpoints.
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Pain Management and Humane Endpoints Meeting
The Johns Hopkins Center for Alternatives to Animal Testing.
From a CAAT, NIH, NAS conference held in November 1998. Topics include philosophy, assessment, alleviation, and policies for the regulation of pain.
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Choosing an Appropriate Endpoint in Experiments Using Animals for Research, Teaching and Testing  (PDF|720 KB)
Canadian Council on Animal Care.
These guidelines define endpoints and discuss the joint responsibility of animal care committees with the investigator and the veterinary staff to ensure that the earliest endpoints consistent with producing reliable data are considered, identified and used.
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Animal Welfare Policy Statements
American Veterinary Medical Association.
Position statements covering recommendations on antimicrobial use, euthanasia, abuse, pain, and other important animal welfare concerns.
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Animal Euthanasia, 1993
USDA. NAL. Animal Welfare Information Center.
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Last Modified: Aug 7, 2008  
See Also
    Refinement Alternative Resources
    ILAR Journal Issue on Humane Endpoints
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