2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209) Quickview (CASRN 1163-19-5)

Status of Data for 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209)

File First On-Line: 01/31/1987; Last Significant Revision: 06/30/2008

Category (section)	Status	Last Revised
Oral RfD Assessment	On-line	06/30/2008
Inhalation RfC Assessment	Discussion	06/30/2008
Carcinogenicity Assessment	On-line	06/30/2008

Synonyms

1163-19-5 DBDPE DBDPO Decabromobiphenyl ether Decabromobiphenyl oxide

Decabromodiphenyl ether Decabromodiphenyl oxide Decabromophenyl ether Ether, bis(pentabromophenyl) more...

Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect	Point of Departure*	UF	MF	RfD
Neurobehavioral effects	NOAEL : 2.22 mg/kg	300	1	7 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

• Principal and Supporting Studies (Oral RfD)
  • Single dose gavage study in mice, Viberg et al., 2003
• Confidence in the Oral RfD
  • Study -- Low
  • Database -- Medium
  • RfD -- Low

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

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Carcinogenicity Assessment for Lifetime Exposure

• Weight-of-Evidence Characterization
  • Suggestive evidence of carcinogenic potential
• Weight-of-Evidence Narrative:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for decabromodiphenyl ether provides suggestive evidence of carcinogenic potential.
  • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

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Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)	Extrapolation Method
7 x10-4 per mg/kg-day	Multistage model with linear extrapolation from the point of departure (LED12).

Drinking Water Unit Risks
2x10-8 per ug/L

Risk Level	Concentration
E-4 (1 in 10,000)	5000 ug/L
E-5 (1 in 100,000)	500 ug/L
E-6 (1 in 1,000,000)	50 ug/L

• Dose-Response Data (Carcinogenicity, Oral Exposure)
  • Tumor Type: Liver neoplastic nodules or carcinoma (combined)
  • Test Species: Male F344/N rats
  • Route: Oral, diet
  • Reference: NTP (1986)

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Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

• Not Assessed under the IRIS Program.