[Federal Register: November 15, 2004 (Volume 69, Number 219)]
[Notices]
[Page 65613-65615]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr15no04-94]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program (NTP) Board of Scientific Counselors
Technical Reports Review Subcommittee Meeting; Review of Draft NTP
Technical Reports
Pursuant to Pub. L. 92-463, notice is hereby given of the next
meeting of the NTP Board of Scientific Counselors Technical Reports
Review Subcommittee (``TRR Subcommittee'') on December 9-10, 2004, in
the Rodbell Auditorium, Rall Building at the
[[Page 65614]]
National Institute of Environmental Health Sciences, 111 T.W. Alexander
Drive, Research Triangle Park, NC 27709. The meeting will begin each
day at 8:30 a.m. The meeting is open to the public with attendance
limited only by the space available (see ``Attendance, Registration,
and Remote Access'' below).
Agenda
The primary agenda topic is the peer review by the TRR Subcommittee
of the findings and conclusions of seven draft NTP Technical Reports
(TR) of rodent toxicology and carcinogenesis studies conducted by the
NTP (see Preliminary Agenda below). There will also be a presentation
on how the NTP handles contaminants in study materials and their impact
on the interpretation of 2-year bioassays. In addition, at the request
of the NTP Board of Scientific Counselors, the TRR Subcommittee will
readdress the title of the Draft NTP Technical Report on Anthraquinone
(see minutes from the NTP Board of Scientific Counselors meeting held
June 29, 2004, available at http://ntp-server.niehs.nih.gov/ntpweb/index.cfm?objectid=720164E3-BDB7-CEBA-F338FA2626639D56
). As an
introduction to the reports on the studies of polychlorinated biphenyl
(PCB), a short presentation will be given on the use of Toxic
Equivalency Factors (TEFs). The TEF methodology was developed as a
mathematical tool that ranks the dioxin-like activity of a compound
relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent
dioxin. This methodology has been applied to the NTP studies reported
in TR 531: Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) and
2,3',4,4',5-Pentachlorobiphenyl (PCB 118), TR 529: 2,2',4,4',5,5'-
Hexachlorobiphenyl (PCB 153), and TR 530: Mixture of PCB 126 and PCB
153.
A copy of the agenda, TRR Subcommittee roster, and the draft NTP
Technical Reports, as available, will be posted on the NTP Web site
(http://ntp-server.niehs.nih.gov/ under Latest News) and will be
available upon request to the NTP Executive Secretary, Dr. Barbara S.
Shane (PO Box 12233, 111 T.W. Alexander Dr., MD A3-01, Research
Triangle Park, NC 27709, T: 919-541-4253; F: 919-541-0295; e-mail:
shane@niehs.nih.gov). Following the meeting, summary minutes will be
available on the TRR Subcommittee Web site (see http://ntp-server.niehs.nih.gov/ntpweb/index.cfm?objectid=227FC084=EB0C-7E93-9DCD6F03104F0D22
) and in hard copy upon request to the NTP Executive
Secretary.
Draft Reports Available for Public Review and Comment
Approximately four weeks prior to the meeting, the draft reports
will be available for public review, through the NTP Web page (http://ntp-server.niehs.nih.gov/
under Latest News). Printed copies of the
Draft NTP Technical Reports can be obtained, as available, from Central
Data Management (NIEHS, PO Box 12233, MD EC-03, Research Triangle Park,
NC 27709, T: 919-541-3419, F: 919-541-3687, e-mail: CDM@niehs.nih.gov).
Attendance, Registration and Remote Access
The meeting is open to the public with attendance limited only by
the space available. Individuals who plan to attend are strongly
encouraged to register with the NTP Executive Secretary by December 2,
2004 to ensure easy access to the NIEHS campus (contact information
above) or online on the NTP Web site (http://ntp.niehs.nih.gov under
Latest News). Please note that a photo ID is required to access the
NIEHS campus. Persons needing special assistance, such as sign language
interpretation or other reasonable accommodation in order to attend are
asked to notify the NTP Executive Secretary at least seven business
days in advance of the meeting. The NTP is also making plans to
videocast the TRR Subcommittee meeting through the Internet at http://www.niehs.nih.gov/external/video.htm.
The NTP cannot guarantee the
technical quality of the video casting and people wishing to use this
option are encouraged to test their ability to access the video cast at
the above Internet address under Check your live video setup.
Public Comment
Comments on any of the Draft NTP Technical Reports are welcome.
Time will be provided at the meeting for oral public comment on the
reports. Persons requesting time for an oral presentation on a
particular report are asked to notify the NTP Executive Secretary
(contact information given above) by December 2, 2004, and to provide
their contact information (name, affiliation, mailing address, phone,
fax, e-mail), and supporting organization (if any). Persons registering
to make comments are asked to provide a written copy of their statement
to the NTP Executive Secretary on or before December 2, 2004, to enable
review by the TRR Subcommittee and NTP staff prior to the meeting.
These statements can supplement or expand an oral presentation. Each
speaker will be allotted at least 7 minutes and, if time permits, up 10
minutes for presentation of oral comments. Each organization is allowed
one time slot per report being reviewed. Registration for making public
comments will also be available on-site. If registering on-site to
speak and reading comments from printed text, the speaker is asked to
provide 25 copies of the statement for distribution to the Subcommittee
and NTP staff, and to supplement the record.
Written comments without an oral presentation at the meeting are
also welcome. Comments should include contact information for the
submitter (name, affiliation, mailing address, phone, fax, and e-mail)
and supporting organization (if any). Written comments should be
received by the NTP Executive Secretary on or before December 2, 2004,
to enable distribution to the Subcommittee and NTP staff for their
review and consideration prior to the meeting. Written comments
received in response to this notice will be posted on the NTP Web site
(http://ntp.niehs.nih.gov under Latest News).
Request for Additional Information
The NTP would welcome receiving toxicology and carcinogenesis
information from completed, ongoing or planned studies as well as
current production data, human exposure information, and use patterns
for any of the chemicals listed in this announcement. Please send this
information to Central Data Management at the address given above and
it will be forwarded to the appropriate NTP staff.
NTP Technical and Toxicity Report Series
The NTP conducts toxicology and carcinogenesis studies of agents of
public health concern. Any scientist, organization, or member of the
public may nominate a chemical for NTP testing. Details about the
nomination process are available on the NTP Web site (http://ntp.niehs.nih.gov
under Nominations to the Testing Program). The
results of short-term rodent toxicology studies are published in the
NTP Toxicity Report series. Longer-term studies, generally, rodent
carcinogenicity studies, are published in the NTP Technical Report
series. The NTP has a new technical report series for studies conducted
in genetically modified models. PDF files of completed reports are
available free-of-charge at the NTP Web site (http://ntp-server.niehs.nih.gov/index.cfm?objectid=084801F0-F43F-7B74-0BE549908B5E5C1C
).
[[Page 65615]]
NTP Board of Scientific Counselors
The NTP Board of Scientific Counselors (``the Board'') is a
technical advisory body composed of scientists from the public and
private sectors who provide primary scientific oversight and peer
review to the NTP. Specifically, the Board advises the NTP on matters
of scientific program content, both present and future, and conducts
periodic review of the program for the purpose of determining and
advising on the scientific merit of its activities and overall
scientific quality. The TRR Subcommittee of the Board provides
scientific peer review of the findings and conclusions of NTP Technical
Reports. The Report on Carcinogens Subcommittee of the Board provides
scientific peer review of nominations to the Report on Carcinogens, a
Congressionally mandated listing of agents known or reasonably
anticipated to be human carcinogens.
The Board's members are selected from recognized authorities
knowledgeable in fields, such as toxicology, pharmacology, pathology,
biochemistry, epidemiology, risk assessment, carcinogenesis,
mutagenesis, molecular biology, behavioral toxicology, neurotoxicology,
immunotoxicology, reproductive toxicology or teratology, and
biostatistics. The NTP strives for equitable geographic distribution
and for minority and female representation on the Board.
Dated: November 5, 2004.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences.
Preliminary Agenda
National Toxicology Program (NTP) Technical Reports (TR) Scheduled for
Review by the NTP Board of Scientific Counselors Technical Reports
Review Subcommittee
December 9-10, 2004
Rodbell Auditorium, National Institute of Environmental Health
Sciences, 111 TW Alexander Drive, Research Triangle Park, NC.
1. Overview of Dioxin Toxic Equivalency Factors (TEFs).
2. TR 531: Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) and
2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CAS Nos. 57465-28-8 and
31508-00-6, respectively).
No longer used commercially; persistent polyhalogenated
aromatic hydrocarbons present in the environment.
3. TR 529: 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CAS No. 35065-
27-1).
No longer used commercially; persistent polyhalogenated
aromatic hydrocarbon present in the environment.
4. TR 530: Mixture of PCB 126 and PCB 153 (CAS No: 57465-28-8 and
835065-27-1, respectively).
No longer used commercially; persistent polyhalogenated
aromatic hydrocarbons present in the environment.
5. Discussion on Contaminants in NTP Study Materials: Impact on
Interpretation of 2-year Bioassays.
Discussion of the Title of Draft NTP Technical Report on
Anthraquinone (TR-494).
6. TR 517: Sodium Chlorate (CAS No. 7775-09-9).
Oxidizing agent, precursor in the synthesis of chlorine
dioxide; found as byproduct in water disinfected with chlorine dioxide.
7. TR 532: Bromodichloromethane (CAS No. 75-27-4).
Water disinfectant by-product.
8. TR 522: 3'-Azido-3'-thymidine (AZT) (CAS No. 30516-87-1).
Chemotherapeutic agent for treatment of people with
acquired immune deficiency syndrome (AIDS).
9. TR 533: Benzophenone (CAS No. 119-61-9).
Photoinitiator fragrance enhancer, ultraviolet curing
agent, intermediate in the manufacture of agricultural chemicals.
[FR Doc. 04-25280 Filed 11-12-04; 8:45 am]
BILLING CODE 4140-01-P