NINDS Neuroscience Funding Announcements

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Technology Development for Safe and Effective Deep Brain Stimulation
Release Date: July 27, 2001
Announcement Number: RFA-NS-02-004
Application Receipt Date:
October 20, 2001   
Letter of Intent Date: September 20, 2001

Funding Contact: NINDS Funding
Program Area: Neurodegeneration, Repair and Plasticity

Brief Description:
Deep brain stimulation (DBS) in the thalamus for the treatment of tremor was approved by the FDA in 1997 following the pioneering work of Benabid and colleagues in France. Subsequently it has been found that stimulation in the subthalamic nucleus (STN) or globus pallidus (GPi) can relieve multiple symptoms of Parkinson's disease (PD). DBS has been successful in restoring significant mobility to a large number of patients with advanced PD. During the past year, GPi and STN stimulation underwent review at the FDA for potential use to decrease symptoms of dyskinesia, tremor, postural instability, and/or bradykinesia in individuals with advanced PD.

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