2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) Dose-Response Studies: Preliminary Literature Search Results and Request for Additional Studies
Federal Register Notices
Contact
- Annette M. Gatchett
- by phone at: 513-569-7531
- by fax at: 513-569-7475
- by email at: gatchett.annette@epa.gov
- by fax at: 513-569-7475
Notice
[12/29] EPA is announcing a 3-day public, scientific
workshop, including a public review of the recent scientific literature
on 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) dose-response, to assist
EPA in responding to the National Academy of Sciences (NAS) report,
Health Risks from Dioxin and Related Compounds: Evaluation of the EPA
Reassessment (NAS, 2006) as explained in a December 29, 2008 Federal Register Notice. The workshop will be held February 18-20, 2009.
[11/24] EPA announced the release of a preliminary search results list for public review and comment as explained in the November 24, 2008 Federal Register Notice. The deadline for comments is January 9, 2009.
Background
The EPA invites your review of this preliminary list of in vivo mammalian dose-response citations for TCDD. At this time the Agency requests that interested parties submit only peer-reviewed, in vivo mammalian dose-response studies for TCDD including epidemiological studies that are absent from this list. The EPA asks that the inputs include full citations and the full publication. Directions for submitting these additional studies for the Agency’s consideration are provided below. These submissions will be used during the conduct of a scientific expert workshop on TCDD dose-response modeling, open to the public, to be held in Cincinnati, Ohio on February 18-20, 2009 (to be announced in a future Federal Register Notice).
Two additional citation lists are being provided here for convenience. First, the EPA is providing a list of citations relevant to dose-response assessment that were published in Part II (all citations) and Part III of the 2003 draft Dioxin Reassessment (all citations). Second, the EPA also is providing a preliminary list of supporting references published since the release of the 2003 Dioxin Reassessment pertaining to studies of TCDD kinetic data, TCDD mode-of-action, in vitro TCDD studies, and TCDD risk assessment approaches. The EPA is not seeking the submission of additional studies or comments on these types of studies or these two lists at this time.
History/Chronology
Next Steps
Downloads/Related Links
- Preliminary Reference List for 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) in Vivo Mammalian Dose-Response and Epidemiological Studies (PDF) (48 pp, 166 KB, about PDF)
Related Link(s)
- Preliminary Supporting Reference List for 2,3,7,8-Tetrachlorodibenzo P Dioxin (TCDD) Modemechanism of Action, Toxicokinetics, in Vitro Study Data, Modeling-Methodology (PDF) (81 pp, 269 KB, about PDF)
- Reference Citations from Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) and Related Compounds (PDF) (189 pp, 496 KB, about PDF)
- EPA, 2003. Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) and Related Compounds
- NAS, 2006. National Academy of Sciences Health Risks from Dioxin and Related Compounds: Evaluation of the EPA Reassessment
Additional Information
Citation